BDBM50000541 (+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea::1-[1-(1-benzothien-2-yl)ethyl]-1-hydroxyurea::CHEMBL93::Leutrol::N-(1-Benzo(b)thien-2-ylethyl)-N-hydroxyurea::N-[1-(benzo[b]thiophen-2-yl)ethyl]-N-hydroxyurea::ZILEUTON::Zyflo (TN)

SMILES CC(N(O)C(N)=O)c1cc2ccccc2s1

InChI Key InChIKey=MWLSOWXNZPKENC-UHFFFAOYSA-N

Data  1 KI  140 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50000541   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50000541((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Affinity DataIC50:  840nMAssay Description:Inhibitory concentration against human platelet 5-lipoxygenase in dog whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetThromboxane-A synthase(Rattus norvegicus)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50000541((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibitory concentration against human platelet thromboxane synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50000541((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Affinity DataIC50:  5.50E+4nMAssay Description:Inhibitory concentration against human platelet 12-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50000541((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibitory concentration against human platelet 5-lipoxygenase in dog whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50000541((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibitory concentration against human platelet 5-lipoxygenase in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50000541((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Affinity DataIC50:  5.12E+3nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase by reduction of 5-hydroxyeicosatetraenoic acid (5-HETE) formed in guinea pig polymorphonuclear le...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProstaglandin G/H synthase 1/2(Ovis aries (Sheep))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50000541((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase by reduction of LTB4 formed in guinea pig polymorphonuclear leukocytes (PMNs).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed