BDBM50071873 4-[2-(4-Fluoro-phenyl)-5-(4-methanesulfinyl-phenyl)-1H-pyrrol-3-yl]-pyridine::CHEMBL88486

SMILES CS(=O)c1ccc(cc1)-c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1

InChI Key InChIKey=IADKHNLYTDEPGD-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50071873   

TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50071873(4-[2-(4-Fluoro-phenyl)-5-(4-methanesulfinyl-phenyl...)
Affinity DataIC50:  7.61E+3nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50071873(4-[2-(4-Fluoro-phenyl)-5-(4-methanesulfinyl-phenyl...)
Affinity DataIC50:  8.10nMAssay Description:Inhibition of Mitogen-activated protein kinase p38 betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50071873(4-[2-(4-Fluoro-phenyl)-5-(4-methanesulfinyl-phenyl...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of c-Jun N-terminal kinase 1-alpha 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50071873(4-[2-(4-Fluoro-phenyl)-5-(4-methanesulfinyl-phenyl...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50071873(4-[2-(4-Fluoro-phenyl)-5-(4-methanesulfinyl-phenyl...)
Affinity DataIC50:  5.30nMAssay Description:Antagonist activity at human glucagon receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50071873(4-[2-(4-Fluoro-phenyl)-5-(4-methanesulfinyl-phenyl...)
Affinity DataIC50:  470nMAssay Description:Inhibitino of RAF kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50071873(4-[2-(4-Fluoro-phenyl)-5-(4-methanesulfinyl-phenyl...)
Affinity DataIC50:  5.30nMAssay Description:Inhibitory activity against p38-alpha kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50071873(4-[2-(4-Fluoro-phenyl)-5-(4-methanesulfinyl-phenyl...)
Affinity DataIC50:  65nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-beta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50071873(4-[2-(4-Fluoro-phenyl)-5-(4-methanesulfinyl-phenyl...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-beta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Rattus norvegicus)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50071873(4-[2-(4-Fluoro-phenyl)-5-(4-methanesulfinyl-phenyl...)
Affinity DataIC50:  5.10nMAssay Description:Inhibitory potency evaluated against rat p38 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed