Reaction Details Report a problem with these data
Target
Mitogen-activated protein kinase 11
Ligand
BDBM50071873
Substrate
n/a
Meas. Tech.
ChEBML_124652
IC50
8.1±n/a nM
Citation
 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Pyrroles and other heterocycles as inhibitors of p38 kinase. Bioorg Med Chem Lett 8:2689-94 (1999) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 11
Synonyms:
MAP kinase p38 | MAPK11 | MK11_HUMAN | Mitogen-activated protein kinase 11 | Mitogen-activated protein kinase p38 beta | PRKM11 | SAPK2 | SAPK2B | Stress-activated protein kinase 2 | p38 MAP kinase alpha/beta | p38-2 | p38-beta | p38b
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41351.73
Organism:
Homo sapiens (Human)
Description:
gi_20128774
Residue:
364
Sequence:
MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSLEIEQ
  
Inhibitor
Name:
BDBM50071873
Synonyms:
4-[2-(4-Fluoro-phenyl)-5-(4-methanesulfinyl-phenyl)-1H-pyrrol-3-yl]-pyridine | CHEMBL88486
Type:
Small organic molecule
Emp. Form.:
C22H17FN2OS
Mol. Mass.:
376.447
SMILES:
CS(=O)c1ccc(cc1)-c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Structure:
Search PDB for entries with ligand similarity: