BDBM50115581 (Z)-2-Hydroxy-4-oxo-4-(4-phenoxy-phenyl)-but-2-enoic acid::2-Hydroxy-4-oxo-4-(4-phenoxy-phenyl)-but-2-enoic acid::CHEMBL108423::CHEMBL185721::CHEMBL573638

SMILES OC(=O)C(=O)CC(=O)c1ccc(Oc2ccccc2)cc1

InChI Key InChIKey=NHQPPCOWPBXWBJ-UHFFFAOYSA-N

Data  1 KI  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50115581   

TargetPolymerase acidic protein(Hepatitis C virus)
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50115581((Z)-2-Hydroxy-4-oxo-4-(4-phenoxy-phenyl)-but-2-eno...)
Affinity DataKi:  280nMAssay Description:Binding affinity to PA N-terminal domain (Competitive)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA excision repair protein ERCC-5(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50115581((Z)-2-Hydroxy-4-oxo-4-(4-phenoxy-phenyl)-but-2-eno...)
Affinity DataIC50:  1.87E+3nMAssay Description:Concentration required for 50% inhibition of Xeroderma pigmentosum GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFlap endonuclease 1(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50115581((Z)-2-Hydroxy-4-oxo-4-(4-phenoxy-phenyl)-but-2-eno...)
Affinity DataIC50:  1.75E+3nMAssay Description:Concentration required for 50% inhibition of Flap endonuclease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolymerase acidic protein(Hepatitis C virus)
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50115581((Z)-2-Hydroxy-4-oxo-4-(4-phenoxy-phenyl)-but-2-eno...)
Affinity DataEC50:  1.45E+3nMAssay Description:Plaque growth inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute/Nih

Curated by ChEMBL
LigandPNGBDBM50115581((Z)-2-Hydroxy-4-oxo-4-(4-phenoxy-phenyl)-but-2-eno...)
Affinity DataIC50:  7.80E+3nMAssay Description:Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assay in experiment 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute/Nih

Curated by ChEMBL
LigandPNGBDBM50115581((Z)-2-Hydroxy-4-oxo-4-(4-phenoxy-phenyl)-but-2-eno...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory effect on 3'-processing(3'-P) of proviral DNA in an extracellular HIV-1 integrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute/Nih

Curated by ChEMBL
LigandPNGBDBM50115581((Z)-2-Hydroxy-4-oxo-4-(4-phenoxy-phenyl)-but-2-eno...)
Affinity DataIC50:  1.14E+4nMAssay Description:Strand transfer inhibitory activity against HIV-1 integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute/Nih

Curated by ChEMBL
LigandPNGBDBM50115581((Z)-2-Hydroxy-4-oxo-4-(4-phenoxy-phenyl)-but-2-eno...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assay in experiment 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed