BDBM50254387 CHEMBL4062193

SMILES Fc1ccc(Nc2n[nH]c3cc(OC(F)(F)F)cnc23)cc1F

InChI Key InChIKey=QGIXOJCLJSPCPO-UHFFFAOYSA-N

Data  10 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50254387   

TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50254387(CHEMBL4062193)
Affinity DataIC50:  1.82E+4nMAssay Description:Inhibition of Nav1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50254387(CHEMBL4062193)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibition of Nav1.7 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50254387(CHEMBL4062193)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of TRPV1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50254387(CHEMBL4062193)
Affinity DataEC50: >1.00E+4nMAssay Description:Binding affinity to SK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50254387(CHEMBL4062193)
Affinity DataIC50:  20nMAssay Description:Inhibition of full length human TRPA1 at a holding potential of 15 mV measured after 1 min by PatchXpress electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50254387(CHEMBL4062193)
Affinity DataIC50:  330nMAssay Description:Inhibition of full length human TRPA1 at a holding potential of 15 mV measured after 1 min by PatchXpress electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50254387(CHEMBL4062193)
Affinity DataIC50:  2.64E+3nMAssay Description:Inhibition of KCNQ1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50254387(CHEMBL4062193)
Affinity DataEC50:  37nMAssay Description:Binding affinity to C-terminal 10xHis and 1D4-tagged C-terminal-truncated human A2A adenosine receptor (1 to 316 residues) expressed in Pichia pastor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50254387(CHEMBL4062193)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50254387(CHEMBL4062193)
Affinity DataIC50:  11nMAssay Description:Inhibition of rat TRPA1 at a holding potential of 15 mV measured after 1 min by whole-cell manual patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50254387(CHEMBL4062193)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50254387(CHEMBL4062193)
Affinity DataIC50:  11nMAssay Description:Inhibition of full length rat TRPA1 at a holding potential of 15 mV measured after 1 min by PatchXpress electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed