BDBM50254388 CHEMBL4101680

SMILES FC(F)(F)Oc1ccc2c(n[nH]c2c1)-c1ccc(cc1)C#N

InChI Key InChIKey=RIUFXWHYQAUEAO-UHFFFAOYSA-N

Data  9 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50254388   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50254388(CHEMBL4101680)
Affinity DataIC50:  1.77E+4nMAssay Description:Inhibition of Nav1.7 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50254388(CHEMBL4101680)
Affinity DataEC50: >1.00E+4nMAssay Description:Binding affinity to SK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50254388(CHEMBL4101680)
Affinity DataIC50:  686nMAssay Description:Inhibition of full length human TRPA1 at a holding potential of 15 mV measured after 1 min by PatchXpress electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50254388(CHEMBL4101680)
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of KCNQ1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50254388(CHEMBL4101680)
Affinity DataIC50:  246nMAssay Description:Inhibition of full length rat TRPA1 at a holding potential of 15 mV measured after 1 min by PatchXpress electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50254388(CHEMBL4101680)
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of KCNQ2/3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50254388(CHEMBL4101680)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of TRPV1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50254388(CHEMBL4101680)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to C-terminal 10xHis and 1D4-tagged C-terminal-truncated human A2A adenosine receptor (1 to 316 residues) expressed in Pichia pastor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50254388(CHEMBL4101680)
Affinity DataIC50:  195nMAssay Description:Inhibition of full length human TRPA1 oS5 chimera at a holding potential of 15 mV measured after 1 min by PatchXpress electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50254388(CHEMBL4101680)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50254388(CHEMBL4101680)
Affinity DataIC50:  1.73E+4nMAssay Description:Inhibition of Nav1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed