BDBM50336576 3-Thiomorpholin-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile::8-oxo-3-thiomorpholino-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile::CHEMBL595134

SMILES O=c1nc2c3cccc4c(ccc(c2c1C#N)c34)N1CCSCC1

InChI Key InChIKey=BRPRPURMGRJSHP-UHFFFAOYSA-N

Data  8 KI  6 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50336576   

TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Dalian University Of Technology

Curated by ChEMBL
LigandPNGBDBM50336576(3-Thiomorpholin-8-oxo-8H-acenaphtho[1,2-b]pyrrole-...)
Affinity DataKd:  310nMAssay Description:Inhibition of FAM-Bid binding to Bcl-2 (unknown origin) after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Dalian University Of Technology

Curated by ChEMBL
LigandPNGBDBM50336576(3-Thiomorpholin-8-oxo-8H-acenaphtho[1,2-b]pyrrole-...)
Affinity DataKd:  960nMAssay Description:Binding affinity to his-tagged Mcl-1 (unknown origin) expressed in Escherichia coli BL21 (DE3) cells by ITC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Dalian University Of Technology

Curated by ChEMBL
LigandPNGBDBM50336576(3-Thiomorpholin-8-oxo-8H-acenaphtho[1,2-b]pyrrole-...)
Affinity DataKd:  954nMAssay Description:Binding affinity to cMcl-1 (residues 171 to 327) (unknown origin) by ITC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Dalian University Of Technology

Curated by ChEMBL
LigandPNGBDBM50336576(3-Thiomorpholin-8-oxo-8H-acenaphtho[1,2-b]pyrrole-...)
Affinity DataKd:  58nMAssay Description:Inhibition of FAM-Bid binding to Mcl-1 (unknown origin) after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed