BDBM50336646 7-[4-({[3-(2,6-Dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-isoquinolinecarboxylic acid::CHEMBL1672451

SMILES CC(C)c1onc(c1COc1ccc(cc1)-c1ccc2cc(ncc2c1)C(O)=O)-c1c(Cl)cccc1Cl

InChI Key InChIKey=ROJOQLBAMYTRQQ-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50336646   

TargetBile acid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50336646(7-[4-({[3-(2,6-Dichlorophenyl)-5-(1-methylethyl)-4...)
Affinity DataEC50:  77nMAssay Description:Agonist activity at human FXR LBD iexpressed in monkey CV-1 cells assessed as transactivation of luciferase reporter gene expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50336646(7-[4-({[3-(2,6-Dichlorophenyl)-5-(1-methylethyl)-4...)
Affinity DataEC50:  120nMAssay Description:Agonist activity at human FXR LBD assessed as SRC1 peptide recruitment by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed