BDBM50343911 3-Nitro-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenoxy)pyridine::CHEMBL1775098

SMILES [O-][N+](=O)c1cccnc1Oc1ccc(OCCN2CCCC2)cc1

InChI Key InChIKey=NOUAQKRFJDKMJW-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50343911   

TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343911(3-Nitro-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenoxy)py...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of purified COX1 assessed as formation of oxidized TMPD during reduction og PGG2 to PGH2 preincubated for 15 mins by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343911(3-Nitro-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenoxy)py...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343911(3-Nitro-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenoxy)py...)
Affinity DataIC50:  3.40E+4nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343911(3-Nitro-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenoxy)py...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of COX2 in human whole blood assessed as inhibition of LPS-induced PGE2 production after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343911(3-Nitro-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenoxy)py...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of purified COX2 assessed as formation of oxidized TMPD during reduction og PGG2 to PGH2 preincubated for 15 mins by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed