BDBM50345745 3-(chroman-6-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine::CHEMBL1785024::US10544104, Compound 7w::US11247972, Compound 7w::US9765037, Compound 7w

SMILES CC(C)n1nc(-c2ccc3OCCCc3c2)c2c(N)ncnc12

InChI Key InChIKey=QGKJNBCCMVIKIT-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50345745   

TargetCalcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands(Cryptosporidium parvum (strain Iowa II))
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345745(3-(chroman-6-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyr...)
Affinity DataIC50:  110nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCalcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands(Cryptosporidium parvum (strain Iowa II))
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345745(3-(chroman-6-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyr...)
Affinity DataIC50:  110nMAssay Description:Kinase phosphorylation reactions were performed in a buffered medium containing 20 mM HEPES pH 7.5 (KOH), 0.1% BSA, 10 mM MgCl2, 1 mM EGTA (pH 7.2), ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcGMP-dependent protein kinase()
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345745(3-(chroman-6-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyr...)
Affinity DataIC50:  17nMAssay Description:Kinase phosphorylation reactions were performed in a buffered medium containing 20 mM HEPES pH 7.5 (KOH), 0.1% BSA, 10 mM MgCl2, 1 mM EGTA (pH 7.2), ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcGMP-dependent protein kinase()
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345745(3-(chroman-6-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyr...)
Affinity DataIC50:  17nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails US Patent