BDBM50364378 CHEMBL1950289

SMILES O[C@H]1CC[C@@H](CC1)Nc1ncc2nc(Nc3c(F)cc(F)cc3F)n([C@H]3CCOC3)c2n1

InChI Key InChIKey=IBGLGMOPHJQDJB-IHRRRGAJSA-N

Data  2 KI  16 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50364378   

TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataKi:  6.20nMAssay Description:Inhibition of hexa-His-tagged JNK2 expressed in baculoviral system using GST-tagged cJun as substrate preincubated for 15 mins prior ATP addition mea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataKi:  44nMAssay Description:Inhibition of hexa-His-tagged JNK1 expressed in baculoviral system using GST-tagged c-Jun as substrate preincubated for 15 mins prior ATP addition me...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataIC50:  6nMAssay Description:Inhibition of hexa-His-tagged JNK3 expressed in baculoviral system using GST-tagged cJun as substrate preincubated for 15 mins prior ATP addition mea...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of p38alpha using myelin basic protein as substrate preincubated for 15 mins prior ATP addition measured after 60 mins by scintillation co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 3(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataIC50:  480nMAssay Description:Inhibition of ERK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataIC50:  380nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataIC50:  61nMAssay Description:Inhibition of hexa-His-tagged JNK1 expressed in baculoviral system using GST-tagged c-Jun as substrate preincubated for 15 mins prior ATP addition me...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataIC50:  7nMAssay Description:Inhibition of hexa-His-tagged JNK2 expressed in baculoviral system using GST-tagged cJun as substrate preincubated for 15 mins prior ATP addition mea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed