BDBM50383292 CHEMBL2029438

SMILES COc1cc(ccc1Nc1ncc2CN(Cc3ccccc3)C(=O)N(c3cccc(NC(=O)C=C)c3)c2n1)N1CCN(C)CC1

InChI Key InChIKey=JARUUYXHPLGHLF-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50383292   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50383292(CHEMBL2029438)
Affinity DataIC50:  0.290nMAssay Description:Inhibition of EGFR after 1.5 hr by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50383292(CHEMBL2029438)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of EGFR L858R/T790M double mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50383292(CHEMBL2029438)
Affinity DataKd:  1.20nMAssay Description:Binding affinity to EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed