BDBM50560402 LIK-066::Licogliflozin::Lik066::USRE49080, Example 62

SMILES CCc1ccc(cc1Cc1ccc2OCCOc2c1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O

InChI Key InChIKey=XFJAMQQAAMJFGB-ZQGJOIPISA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50560402   

TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50560402(LIK-066 | Licogliflozin | Lik066 | USRE49080, Exam...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of SGLT1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50560402(LIK-066 | Licogliflozin | Lik066 | USRE49080, Exam...)
Affinity DataIC50:  22nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50560402(LIK-066 | Licogliflozin | Lik066 | USRE49080, Exam...)
Affinity DataIC50:  0.5nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50560402(LIK-066 | Licogliflozin | Lik066 | USRE49080, Exam...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed