BDBM507762 7-chloro-4-(dimethylamino)-1-phenyl- quinazolin-2(1H)-one::US11046691, Compound 24::US11084798, Cpd No 24::US11130759, Cpd. No. 24

SMILES CN(C)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12

InChI Key InChIKey=JMLJEYLWRAPHBL-UHFFFAOYSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 507762   

TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM507762(7-chloro-4-(dimethylamino)-1-phenyl- quinazolin-2(...)
Affinity DataIC50: <200nMAssay Description:Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...More data for this Ligand-Target Pair
TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM507762(7-chloro-4-(dimethylamino)-1-phenyl- quinazolin-2(...)
Affinity DataIC50: <200nMAssay Description:5 μL of 3× final concentration test compounds in DMSO or DMSO were transferred to the appropriate wells of a microtiter plate and the plate was ...More data for this Ligand-Target Pair
TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM507762(7-chloro-4-(dimethylamino)-1-phenyl- quinazolin-2(...)
Affinity DataIC50: <200nMAssay Description:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Substrate: Alfa...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM507762(7-chloro-4-(dimethylamino)-1-phenyl- quinazolin-2(...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of hERG by plate-based planar patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM507762(7-chloro-4-(dimethylamino)-1-phenyl- quinazolin-2(...)
Affinity DataIC50:  25nMAssay Description:Inhibition of PRMT5 in human HCT116-MTAP null cells assessed as reduction in symmetric dimethylation of arginine using SAM as substrate incubated for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM507762(7-chloro-4-(dimethylamino)-1-phenyl- quinazolin-2(...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM507762(7-chloro-4-(dimethylamino)-1-phenyl- quinazolin-2(...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM507762(7-chloro-4-(dimethylamino)-1-phenyl- quinazolin-2(...)
Affinity DataIC50:  22nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair