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Found 100 with Last Name = 'yuan' and Initial = 'g'
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM403460(US10335399, Example 2-5 | US10806724, Example 2-5)
Affinity DataKi:  59nMAssay Description:Binding affinity to human recombinant mGlur2 assessed as inhibition constant by cAMP Glosensor assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM403460(US10335399, Example 2-5 | US10806724, Example 2-5)
Affinity DataKi:  59nMAssay Description:Binding affinity to human recombinant mGlur2 assessed as inhibition constant by cAMP Glosensor assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50584759(CHEMBL5089623)
Affinity DataKi:  63nMAssay Description:Binding affinity to human recombinant mGlur2 assessed as inhibition constant by cAMP Glosensor assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50584759(CHEMBL5089623)
Affinity DataKi:  63nMAssay Description:Binding affinity to human recombinant mGlur2 assessed as inhibition constant by cAMP Glosensor assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM403460(US10335399, Example 2-5 | US10806724, Example 2-5)
Affinity DataIC50:  6nMAssay Description:Negative allosteric modulation activity at human recombinant mGlur2 expressed in CHO cells in presence of cAMP by chemiluminescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM393885(US10597367, Example 182 | US9969726, Example 182)
Affinity DataIC50:  8.30nMAssay Description:Negative allosteric modulator activity at human recombinant mGlur2 expressed in HEK293 cells by calcium assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM11695((2S)-1-{2-[(3-hydroxyadamantan-1-yl)amino]acetyl}p...)
Affinity DataIC50:  9nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320285((3aR,5beta,6aS)-5-(2-((S)-2-cyanopyrrolidin-1-yl)-...)
Affinity DataIC50:  9nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320293((3aR,5alpha,6aS)-5-(2-((S)-2-cyanopyrrolidin-1-yl)...)
Affinity DataIC50:  13nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320294((3aR,5beta,6aS)-5-(2-((S)-2-cyanopyrrolidin-1-yl)-...)
Affinity DataIC50:  13nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320291((S)-1-(2-((3aR,5beta,6aS)-2-(2-hydroxyacetyl)octah...)
Affinity DataIC50:  14nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320290((3aR,5beta,6aS)-methyl 5-(2-((S)-2-cyanopyrrolidin...)
Affinity DataIC50:  24nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320287((3aR,5beta,6aS)-N-butyl-5-(2-((S)-2-cyanopyrrolidi...)
Affinity DataIC50:  39nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320289((3aR,5beta,6aS)-5-(2-((S)-2-cyanopyrrolidin-1-yl)-...)
Affinity DataIC50:  50nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320288((3aR,5beta,6aS)-5-(2-((S)-2-cyanopyrrolidin-1-yl)-...)
Affinity DataIC50:  69nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320292((3aR,5alpha,6aS)-5-(2-((S)-2-cyanopyrrolidin-1-yl)...)
Affinity DataIC50:  83nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50584759(CHEMBL5089623)
Affinity DataIC50:  93nMAssay Description:Negative allosteric modulation activity at human recombinant mGlur2 expressed in CHO cells in presence of cAMP by chemiluminescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50584759(CHEMBL5089623)
Affinity DataIC50:  93nMAssay Description:Negative allosteric modulation activity at human recombinant mGlur2 expressed in CHO cells in presence of cAMP by chemiluminescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320286((3aR,5beta,6aS)-5-(2-((S)-2-cyanopyrrolidin-1-yl)-...)
Affinity DataIC50:  120nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM11695((2S)-1-{2-[(3-hydroxyadamantan-1-yl)amino]acetyl}p...)
Affinity DataIC50:  230nMAssay Description:Inhibition of DPP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320294((3aR,5beta,6aS)-5-(2-((S)-2-cyanopyrrolidin-1-yl)-...)
Affinity DataIC50:  2.43E+3nMAssay Description:Inhibition of DPP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50449051(CHEMBL3126485)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of HIF-1 alpha in human MDA-MB-468 cells by Western blotting analysis in hypoxia conditionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50449051(CHEMBL3126485)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of HIF-1 alpha in human OVCAR3 cells by Western blotting analysis in hypoxia conditionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50449051(CHEMBL3126485)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of HIF-1 alpha in human PANC1 cells by Western blotting analysis in hypoxia conditionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50449051(CHEMBL3126485)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of HIF-1 alpha in human MDA-MB-231 cells by Western blotting analysis in hypoxia conditionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM11695((2S)-1-{2-[(3-hydroxyadamantan-1-yl)amino]acetyl}p...)
Affinity DataIC50:  3.82E+3nMAssay Description:Inhibition of DPP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50449051(CHEMBL3126485)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of Stat3 phosphorylation in human MDA-MB-468 cells by Western blotting analysis in hypoxia conditionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50449051(CHEMBL3126485)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of Stat3 phosphorylation in human OVCAR3 cells by Western blotting analysis in normoxia conditionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50449051(CHEMBL3126485)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of Stat3 phosphorylation in human OVCAR3 cells by Western blotting analysis in hypoxia conditionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50449051(CHEMBL3126485)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of Stat3 phosphorylation in human MDA-MB-231 cells by Western blotting analysis in hypoxia conditionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50449051(CHEMBL3126485)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of Stat3 phosphorylation in human PANC1 cells by Western blotting analysis in normoxia conditionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50449051(CHEMBL3126485)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of Stat3 phosphorylation in human PANC1 cells by Western blotting analysis in hypoxia conditionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50449051(CHEMBL3126485)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of Stat3 phosphorylation in human MDA-MB-231 cells by Western blotting analysis in normoxia conditionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50449051(CHEMBL3126485)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of Stat3 phosphorylation in human MDA-MB-468 cells by Western blotting analysis in normoxia conditionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320293((3aR,5alpha,6aS)-5-(2-((S)-2-cyanopyrrolidin-1-yl)...)
Affinity DataIC50:  4.89E+3nMAssay Description:Inhibition of DPP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320290((3aR,5beta,6aS)-methyl 5-(2-((S)-2-cyanopyrrolidin...)
Affinity DataIC50:  5.04E+3nMAssay Description:Inhibition of DPP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320285((3aR,5beta,6aS)-5-(2-((S)-2-cyanopyrrolidin-1-yl)-...)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of DPP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Food Industry Research and Development Institute

US Patent
LigandPNGBDBM145862(US8957057, Monascuspiloin)
Affinity DataIC50:  1.20E+4nMAssay Description:To conduct the assays, the 250 uM monasuspiloin solution was further diluted with 10% DMSO to prepare 25 uM, and 5 uM monasuspiloin samples, and the ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Food Industry Research and Development Institute

US Patent
LigandPNGBDBM145862(US8957057, Monascuspiloin)
Affinity DataIC50:  1.60E+4nMAssay Description:To conduct the assays, the 250 uM monasuspiloin solution was further diluted with 10% DMSO to prepare 25 uM, and 5 uM monasuspiloin samples, and the ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320293((3aR,5alpha,6aS)-5-(2-((S)-2-cyanopyrrolidin-1-yl)...)
Affinity DataIC50:  1.69E+4nMAssay Description:Inhibition of DPP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320285((3aR,5beta,6aS)-5-(2-((S)-2-cyanopyrrolidin-1-yl)-...)
Affinity DataIC50:  1.74E+4nMAssay Description:Inhibition of DPP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320290((3aR,5beta,6aS)-methyl 5-(2-((S)-2-cyanopyrrolidin...)
Affinity DataIC50:  1.82E+4nMAssay Description:Inhibition of DPP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Food Industry Research and Development Institute

US Patent
LigandPNGBDBM145862(US8957057, Monascuspiloin)
Affinity DataIC50:  2.70E+4nMAssay Description:To conduct the assays, the 250 uM monasuspiloin solution was further diluted with 10% DMSO to prepare 25 uM, and 5 uM monasuspiloin samples, and the ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlucocorticoid receptor(Homo sapiens (Human))
Food Industry Research and Development Institute

US Patent
LigandPNGBDBM145862(US8957057, Monascuspiloin)
Affinity DataIC50:  3.50E+4nMAssay Description:To conduct the assays, the 250 uM monasuspiloin solution was further diluted with 10% DMSO to prepare 25 uM, and 5 uM monasuspiloin samples, and the ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320294((3aR,5beta,6aS)-5-(2-((S)-2-cyanopyrrolidin-1-yl)-...)
Affinity DataIC50:  3.85E+4nMAssay Description:Inhibition of DPP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50194617(CHEMBL3926416)
Affinity DataEC50:  166nMAssay Description:Positive allosteric modulation of mGlu2 receptor (unknown origin) expressed in human Flp-In-T-REx-293 cells in presence of L-glutamate by luciferase ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50194707(CHEMBL3938796)
Affinity DataEC50:  20nMAssay Description:Positive allosteric modulation of mGlu2 receptor (unknown origin) expressed in human Flp-In-T-REx-293 cells in presence of L-glutamate by luciferase ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50601001(CHEMBL5207431)
Affinity DataEC50:  11nMAssay Description:Positive allosteric modulation of mGlu2 receptor (unknown origin) expressed in human Flp-In-T-REx-293 cells in presence of L-glutamate by luciferase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50601002(CHEMBL5208947)
Affinity DataEC50:  8.30nMAssay Description:Positive allosteric modulation of mGlu2 receptor (unknown origin) expressed in human Flp-In-T-REx-293 cells in presence of L-glutamate by luciferase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50601003(CHEMBL5179002)
Affinity DataEC50:  913nMAssay Description:Positive allosteric modulation of mGlu2 receptor (unknown origin) expressed in human Flp-In-T-REx-293 cells in presence of L-glutamate by luciferase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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