Found 1209 with Last Name = 'zou' and Initial = 'g' TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Suzhou Ark Biopharmaceutical
US Patent
Suzhou Ark Biopharmaceutical
US Patent
Affinity DataIC50: 0nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at R848 stimulated TRL8 overexpressed in HEK293 cells measured after 20 to 24 hrs by SEAP reporter assayMore data for this Ligand-Target Pair
3D Structure (crystal)TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Roche Innovation Center Shanghai
Curated by ChEMBL
Roche Innovation Center Shanghai
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of BTK (unknown origin) One-hour enzymatic assay without pre-incubationMore data for this Ligand-Target Pair
Affinity DataIC50: <0.5nMAssay Description:Antagonist activity at TLR7 in human PBMC incubated for 3 hrs by TR-FRET assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Roche Innovation Center Shanghai
Curated by ChEMBL
Roche Innovation Center Shanghai
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of BTK (unknown origin) One-hour enzymatic assay without pre-incubationMore data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Antagonist activity at R848 stimulated TRL8 overexpressed in HEK293 cells measured after 20 to 24 hrs by SEAP reporter assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Roche Innovation Center Shanghai
Curated by ChEMBL
Roche Innovation Center Shanghai
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human BTK in human microglia cellsMore data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Mus musculus)
Roche Innovation Center Shanghai
Curated by ChEMBL
Roche Innovation Center Shanghai
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta level incubated for 1 hr followed by ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Roche Innovation Center Shanghai
Curated by ChEMBL
Roche Innovation Center Shanghai
Curated by ChEMBL
Affinity DataIC50: <1nMAssay Description:Inhibition of human JAK3 using Biotin-Lyn-Substrate-2 in presence of 1 mM ATP by phosphotyrosine-specific ELISAMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Roche Innovation Center Shanghai
Curated by ChEMBL
Roche Innovation Center Shanghai
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of BTK (unknown origin) One-hour enzymatic assay without pre-incubationMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Roche Innovation Center Shanghai
Curated by ChEMBL
Roche Innovation Center Shanghai
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of BTK (unknown origin) One-hour enzymatic assay without pre-incubationMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Compound concentration required to induce transcriptional activation in MVLN cells equal to 50% of 0.1 nM estradiol responseMore data for this Ligand-Target Pair
Affinity DataIC50: <3nMAssay Description:Antagonist activity at R848 stimulated TRL7 in HEK-Blue hTLR7 cells assessed as inhibition of NF kappa B/Ap-1 activation measured after 20 hrs by SEA...More data for this Ligand-Target Pair
Affinity DataIC50: <3nMAssay Description:Antagonist activity at R848 stimulated TRL8 in HEK-Blue hTLR8 cells assessed as inhibition of NF kappa B/Ap-1 activation measured after 20 hrs by SEA...More data for this Ligand-Target Pair
Affinity DataIC50: <3nMAssay Description:Antagonist activity at R848 stimulated TRL8 in HEK-Blue hTLR8 cells assessed as inhibition of NF kappa B/Ap-1 activation measured after 20 hrs by SEA...More data for this Ligand-Target Pair
Affinity DataIC50: <3nMAssay Description:Antagonist activity at R848 stimulated TRL7 in HEK-Blue hTLR7 cells assessed as inhibition of NF kappa B/Ap-1 activation measured after 20 hrs by SEA...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Suzhou Ark Biopharmaceutical
US Patent
Suzhou Ark Biopharmaceutical
US Patent
Affinity DataIC50: 3.80nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Compound concentration required to induce transcriptional activation in MVLN cells equal to 50% of 0.1 nM estradiol responseMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Antagonist activity at R848 stimulated TRL7 in HEK-Blue hTLR7 cells assessed as inhibition of NF kappa B/Ap-1 activation measured after 20 hrs by SEA...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Roche Innovation Center Shanghai
Curated by ChEMBL
Roche Innovation Center Shanghai
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human JAK1 using Biotin-Lyn-Substrate-2 in presence of 1 mM ATP by phosphotyrosine-specific ELISAMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Roche Innovation Center Shanghai
Curated by ChEMBL
Roche Innovation Center Shanghai
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human JAK1 assessed as phosphorylation level in presence of 1 mM ATPMore data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Suzhou Ark Biopharmaceutical
US Patent
Suzhou Ark Biopharmaceutical
US Patent
Affinity DataIC50: 4.40nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Suzhou Ark Biopharmaceutical
US Patent
Suzhou Ark Biopharmaceutical
US Patent
Affinity DataIC50: 4.60nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Antagonist activity at R848 stimulated TRL8 in HEK-Blue hTLR8 cells assessed as inhibition of NF kappa B/Ap-1 activation measured after 20 hrs by SEA...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Antagonist activity at R848 stimulated TRL8 in HEK-Blue hTLR8 cells assessed as inhibition of NF kappa B/Ap-1 activation measured after 20 hrs by SEA...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Antagonist activity at TLR9 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Roche Innovation Center Shanghai
Curated by ChEMBL
Roche Innovation Center Shanghai
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human JAK2 using Biotin-Lyn-Substrate-2 in presence of 1 mM ATP by phosphotyrosine-specific ELISAMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Roche Innovation Center Shanghai
Curated by ChEMBL
Roche Innovation Center Shanghai
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human Tyk2 using Biotin-Lyn-Substrate-2 in presence of 1 mM ATP by phosphotyrosine-specific ELISAMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Roche Innovation Center Shanghai
Curated by ChEMBL
Roche Innovation Center Shanghai
Curated by ChEMBL
Affinity DataIC50: 5.10nMAssay Description:Inhibition of BTK (unknown origin) One-hour enzymatic assay with pre-incubationMore data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Suzhou Ark Biopharmaceutical
US Patent
Suzhou Ark Biopharmaceutical
US Patent
Affinity DataIC50: 5.20nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Suzhou Ark Biopharmaceutical
US Patent
Suzhou Ark Biopharmaceutical
US Patent
Affinity DataIC50: 5.5nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Compound concentration required to induce transcriptional activation in MVLN cells equal to 50% of 0.1 nM estradiol responseMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Compound concentration required to induce transcriptional activation in MVLN cells equal to 50% of 0.1 nM estradiol responseMore data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Suzhou Ark Biopharmaceutical
US Patent
Suzhou Ark Biopharmaceutical
US Patent
Affinity DataIC50: 7.40nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Antagonist activity at TLR8 in human PBMC incubated for 3 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Antagonist activity at R848 stimulated TRL7 in HEK-Blue hTLR7 cells assessed as inhibition of NF kappa B/Ap-1 activation measured after 20 hrs by SEA...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of full length human cGAS expressed in Escherichia coli BL21 (DE3) incubated for 2 hrs in presence of ATP by RF-MS analysisMore data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Suzhou Ark Biopharmaceutical
US Patent
Suzhou Ark Biopharmaceutical
US Patent
Affinity DataIC50: 11nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Suzhou Ark Biopharmaceutical
US Patent
Suzhou Ark Biopharmaceutical
US Patent
Affinity DataIC50: 11nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Suzhou Ark Biopharmaceutical
US Patent
Suzhou Ark Biopharmaceutical
US Patent
Affinity DataIC50: 11nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Suzhou Ark Biopharmaceutical
US Patent
Suzhou Ark Biopharmaceutical
US Patent
Affinity DataIC50: 12nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Suzhou Ark Biopharmaceutical
US Patent
Suzhou Ark Biopharmaceutical
US Patent
Affinity DataIC50: 13nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Suzhou Ark Biopharmaceutical
US Patent
Suzhou Ark Biopharmaceutical
US Patent
Affinity DataIC50: 15nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Antagonist activity at R848 stimulated TRL7 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincubated with comp...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Suzhou Ark Biopharmaceutical
US Patent
Suzhou Ark Biopharmaceutical
US Patent
Affinity DataIC50: 17nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Roche Innovation Center Shanghai
Curated by ChEMBL
Roche Innovation Center Shanghai
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human JAK1 assessed as phosphorylation level in presence of 1 mM ATPMore data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Suzhou Ark Biopharmaceutical
US Patent
Suzhou Ark Biopharmaceutical
US Patent
Affinity DataIC50: 18nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Suzhou Ark Biopharmaceutical
US Patent
Suzhou Ark Biopharmaceutical
US Patent
Affinity DataIC50: 19nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Suzhou Ark Biopharmaceutical
US Patent
Suzhou Ark Biopharmaceutical
US Patent
Affinity DataIC50: 21nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Suzhou Ark Biopharmaceutical
US Patent
Suzhou Ark Biopharmaceutical
US Patent
Affinity DataIC50: 23nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
