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Found 349 with Last Name = 'kanesaka' and Initial = 'm'
TargetHistamine H3 receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296171(1-{3-[4-((2S,3S)-8-Methoxy-3-methyl-4,4-dioxo-3,4-...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]R-alpha-methylistamine from human histamine H3 receptor by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296171(1-{3-[4-((2S,3S)-8-Methoxy-3-methyl-4,4-dioxo-3,4-...)
Affinity DataKi:  2.80nMAssay Description:Displacement of [3H]R-alpha-methylistamine from rat histamine H3 receptor by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Mus musculus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296171(1-{3-[4-((2S,3S)-8-Methoxy-3-methyl-4,4-dioxo-3,4-...)
Affinity DataKi:  5.90nMAssay Description:Displacement of [3H]R-alpha-methylistamine from mouse histamine H3 receptor by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296179((+/-)-1-Cyclobutyl-4-[4-(8-methoxy-3-methyl-4,4-di...)
Affinity DataIC50:  0.160nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of R-alpha-methylistamine-induced [35S]GTPgammaS binding by cel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296178((+/-)-(S)-1-{3-[4-(8-Methoxy-3-methyl-4,4-dioxo-3,...)
Affinity DataIC50:  0.160nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of R-alpha-methylistamine-induced [35S]GTPgammaS binding by cel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296176((+/-)-(R)-1-{3-[4-(8-Methoxy-3-methyl-4,4-dioxo-3,...)
Affinity DataIC50:  0.210nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of R-alpha-methylistamine-induced [35S]GTPgammaS binding by cel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296174((+/-)-1-{3-[4-(7-Methoxy-3-methyl-4,4-dioxo-3,4-di...)
Affinity DataIC50:  0.320nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of R-alpha-methylistamine-induced [35S]GTPgammaS binding by cel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296175((+/-)-1-{3-[4-(8-Methoxy-3-methyl-4,4-dioxo-3,4-di...)
Affinity DataIC50:  0.340nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of R-alpha-methylistamine-induced [35S]GTPgammaS binding by cel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296171(1-{3-[4-((2S,3S)-8-Methoxy-3-methyl-4,4-dioxo-3,4-...)
Affinity DataIC50:  0.390nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of R-alpha-methylistamine-induced [35S]GTPgammaS binding by cel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296173((+/-)-1-{3-[4-(6-Methoxy-3-methyl-4,4-dioxo-3,4-di...)
Affinity DataIC50:  0.400nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of R-alpha-methylistamine-induced [35S]GTPgammaS binding by cel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296171(1-{3-[4-((2S,3S)-8-Methoxy-3-methyl-4,4-dioxo-3,4-...)
Affinity DataIC50:  0.430nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of R-alpha-methylistamine-induced [35S]GTPgammaS binding by cel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296172((+/-)-1-{3-[4-(5-Methoxy-3-methyl-4,4-dioxo-3,4-di...)
Affinity DataIC50:  0.440nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of R-alpha-methylistamine-induced [35S]GTPgammaS binding by cel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296188(CHEMBL558248 | trans-1-{3-[4-(3-Methyl-4,4-dioxo-3...)
Affinity DataIC50:  0.600nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of R-alpha-methylistamine-induced [35S]GTPgammaS binding by cel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296181((+/-)-1-{3-[4-(3-Methyl-4,4-dioxo-3,4-dihydro-2H-4...)
Affinity DataIC50:  0.600nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of R-alpha-methylistamine-induced [35S]GTPgammaS binding by cel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296180(1-{3-[4-((2R,3R)-8-Methoxy-3-methyl-4,4-dioxo-3,4-...)
Affinity DataIC50:  0.607nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of R-alpha-methylistamine-induced [35S]GTPgammaS binding by cel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296177((+/-)-(S)-1-{3-[4-(8-Methoxy-3-methyl-4,4-dioxo-3,...)
Affinity DataIC50:  0.820nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of R-alpha-methylistamine-induced [35S]GTPgammaS binding by cel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296189(1-{3-[4-(3-Methyl-4,4-dioxo-4H-4lambda*6*-benzo[1,...)
Affinity DataIC50:  0.840nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of R-alpha-methylistamine-induced [35S]GTPgammaS binding by cel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50304315(CHEMBL593465 | trans-3-Oxo-N-(2-phenyl-2H-1,2,3-tr...)
Affinity DataIC50:  0.890nMAssay Description:Displacement of [125I]PYY from human recombinant Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50304301(CHEMBL595790 | trans-N-[1-(3-Fluorophenyl)-1H-pyra...)
Affinity DataIC50:  0.920nMAssay Description:Displacement of [125I]PYY from human recombinant Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50304313(CHEMBL607037 | trans-3-Oxo-N-(2-phenyl-1,3-thiazol...)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [125I]PYY from human recombinant Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50265209(1'-(5-chloro-1H-benzo[d]imidazol-2-yl)-3H-spiro[is...)
Affinity DataIC50:  1.20nMAssay Description:Antagonist activity at human NPY Y5 receptor transfected in mouse LMtk cells assessed as inhibition of neuropeptide Y-induced increase in intercellul...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50304298(CHEMBL595120 | trans-3-Oxo-N-(1-phenyl-1H-pyrazol-...)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [125I]PYY from human recombinant Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50304300(CHEMBL595573 | trans-N-[1-(2-fluorophenyl)-3-pyraz...)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [125I]PYY from human recombinant Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50264726(1'-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)-3H-spir...)
Affinity DataIC50:  1.40nMAssay Description:Antagonist activity at human NPY Y5 receptor transfected in mouse LMtk cells assessed as inhibition of neuropeptide Y-induced increase in intercellul...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50265298(CHEMBL496327 | methyl 2-(3-oxo-3H-spiro[isobenzofu...)
Affinity DataIC50:  1.5nMAssay Description:Antagonist activity at human NPY Y5 receptor transfected in mouse LMtk cells assessed as inhibition of neuropeptide Y-induced increase in intercellul...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50304303(CHEMBL593934 | trans-3-Oxo-N-(5-phenylpyrazin-2-yl...)
Affinity DataIC50:  1.5nMAssay Description:Displacement of [125I]PYY from human recombinant Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50264726(1'-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)-3H-spir...)
Affinity DataIC50:  1.60nMAssay Description:Binding affinity to human NPY Y5 receptor transfected in mouse LMtk cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50264364(CHEMBL491229 | trans-4-[5-(4-Fluoro-phenyl)-1H-ben...)
Affinity DataIC50:  1.70nMAssay Description:Displacement of [125I]PYY from human recombinant NPYY5 receptor expressed in mouse LMtk cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Rat 6B)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50304297(CHEMBL594163 | trans-3-Oxo-N-(1-phenyl-1H-pyrazol-...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of rat Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296185(CHEMBL550393 | trans-1-(3-(4-(3-methyl-2,3-dihydro...)
Affinity DataIC50:  1.80nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of R-alpha-methylistamine-induced [35S]GTPgammaS binding by cel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301656(CHEMBL567527 | trans-1'-oxo-N-(5-phenylpyrimidin-2...)
Affinity DataIC50:  1.80nMAssay Description:Displacement of [125I]PYY from human recombinant Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50265297(1'-(5-isobutyl-1H-benzo[d]imidazol-2-yl)-3H-spiro[...)
Affinity DataIC50:  1.80nMAssay Description:Binding affinity to human NPY Y5 receptor transfected in mouse LMtk cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50265267(1'-(5-phenyl-1H-benzo[d]imidazol-2-yl)-3H-spiro[is...)
Affinity DataIC50:  1.80nMAssay Description:Antagonist activity at human NPY Y5 receptor transfected in mouse LMtk cells assessed as inhibition of neuropeptide Y-induced increase in intercellul...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50265299(CHEMBL524644 | ethyl 2-(3-oxo-3H-spiro[isobenzofur...)
Affinity DataIC50:  2nMAssay Description:Binding affinity to human NPY Y5 receptor transfected in mouse LMtk cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50304316(CHEMBL594164 | trans-N-[1-(4-Fluorophenyl)-1H-pyra...)
Affinity DataIC50:  2nMAssay Description:Displacement of [125I]PYY from human recombinant Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301651(CHEMBL568370 | trans-3'-oxo-N-(5-phenylpyrimidin-2...)
Affinity DataIC50:  2nMAssay Description:Displacement of [125I]PYY from human recombinant Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Rat 6B)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50304300(CHEMBL595573 | trans-N-[1-(2-fluorophenyl)-3-pyraz...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of rat Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50264493(CHEMBL489608 | trans-4-[5-(5-Trifluoromethyl-[1,2,...)
Affinity DataIC50:  2.10nMAssay Description:Displacement of [125I]PYY from human recombinant NPYY5 receptor expressed in mouse LMtk cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Rat 6B)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50304301(CHEMBL595790 | trans-N-[1-(3-Fluorophenyl)-1H-pyra...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of rat Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50304312(CHEMBL604480 | trans-3-Oxo-N-(5-phenylpyridin-2-yl...)
Affinity DataIC50:  2.10nMAssay Description:Displacement of [125I]PYY from human recombinant Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50304310(CHEMBL596264 | trans-3-Oxo-N-(5-phenylisoxazol-3-y...)
Affinity DataIC50:  2.10nMAssay Description:Displacement of [125I]PYY from human recombinant Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301644(CHEMBL568144 | trans-3-Oxo-N-(5-phenylpyrimidin-2-...)
Affinity DataIC50:  2.10nMAssay Description:Displacement of [125I]PYY from human recombinant Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50264395(CHEMBL490824 | trans-4-(5-Chloro-6-phenyl-1H-benzo...)
Affinity DataIC50:  2.20nMAssay Description:Displacement of [125I]PYY from human recombinant NPYY5 receptor expressed in mouse LMtk cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50304309(CHEMBL607144 | trans-3-Oxo-N-(5-phenylpyrazin-2-yl...)
Affinity DataIC50:  2.20nMAssay Description:Displacement of [125I]PYY from human recombinant Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50304314(CHEMBL596025 | trans-3-Oxo-N-(1-phenyl-1H-pyrazol-...)
Affinity DataIC50:  2.20nMAssay Description:Displacement of [125I]PYY from human recombinant Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Rat 6B)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50304299(CHEMBL595560 | trans-3-Oxo-N-(1-phenyl-1H-pyrazol-...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of rat Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50264441(CHEMBL491239 | trans-6-Chloro-2-(3'-oxo-3'H-spiro[...)
Affinity DataIC50:  2.20nMAssay Description:Displacement of [125I]PYY from human recombinant NPYY5 receptor expressed in mouse LMtk cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50264853(1'-(2,2-difluoro-5H-[1,3]dioxolo[4,5-f]benzimidazo...)
Affinity DataIC50:  2.20nMAssay Description:Binding affinity to human NPY Y5 receptor transfected in mouse LMtk cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50264328(CHEMBL489587 | trans-4-(5-Phenyl-1H-benzoimidazol-...)
Affinity DataIC50:  2.30nMAssay Description:Displacement of [125I]PYY from human recombinant NPYY5 receptor expressed in mouse LMtk cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50304299(CHEMBL595560 | trans-3-Oxo-N-(1-phenyl-1H-pyrazol-...)
Affinity DataIC50:  2.30nMAssay Description:Displacement of [125I]PYY from human recombinant Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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