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Found 90 with Last Name = 'cocklin' and Initial = 's'
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))TBA
LigandPNGBDBM50422743(CHEMBL5275219)
Affinity DataKi:  2.80nMAssay Description:Binding affinity to ACE2 (unknown origin) at 10 uM assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))TBA
LigandPNGBDBM50233798(CHEMBL398940 | N-(2-aminoethyl)-1-aziridine-ethana...)
Affinity DataKi:  4.59E+5nMAssay Description:Binding affinity to ACE2 (unknown origin) at 10 uM assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProcathepsin L(Homo sapiens (Human))TBA
LigandPNGBDBM50552672(CHEMBL4790628)
Affinity DataIC50:  0nMAssay Description:Inhibition of human recombinant Cathepsin L assessed as Kinact using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProcathepsin L(Homo sapiens (Human))TBA
LigandPNGBDBM50229129(4-Methyl-piperazine-1-carboxylic acid [(S)-1-((E)-...)
Affinity DataIC50:  0.680nMAssay Description:Inhibition of human recombinant Cathepsin L assessed as Kinact using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))TBA
LigandPNGBDBM50421866(CHEMBL5281591)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant ACE2 at 50 uM using (7Mca-Y-V-A- D -A-P- K(Knp) as a flurogenic substrate measured after 10 mins by fluorescence base...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))TBA
LigandPNGBDBM50421871(CHEMBL5273921)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of SARS-CoV S binding to human recombinant ACE2 expressed in Escherichia coli BL21(DE3) incubated for 2 hrs by ELISA methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProcathepsin L(Homo sapiens (Human))TBA
LigandPNGBDBM50073850((S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyr...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human recombinant Cathepsin L assessed as Kinact using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))TBA
LigandPNGBDBM50421869(CHEMBL5277148)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of SARS-CoV S binding to human recombinant ACE2 expressed in Escherichia coli BL21(DE3) incubated for 2 hrs by ELISA methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProcathepsin L(Homo sapiens (Human))TBA
LigandPNGBDBM51395(CHEMBL263634 | N-[(2S)-1-[[[2-(3,4-dihydro-2H-quin...)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of human recombinant Cathepsin L assessed as Kinact using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))TBA
LigandPNGBDBM50421870(CHEMBL5281306)
Affinity DataIC50:  7nMAssay Description:Inhibition of SARS-CoV S binding to human recombinant ACE2 expressed in Escherichia coli BL21(DE3) incubated for 2 hrs by ELISA methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))TBA
LigandPNGBDBM50422743(CHEMBL5275219)
Affinity DataIC50:  10nMAssay Description:Inhibition of human ACE2 (unknown origin) at 0.5 uMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProcathepsin L(Homo sapiens (Human))TBA
LigandPNGBDBM50374666(CHEMBL259450)
Affinity DataIC50:  56nMAssay Description:Inhibition of human recombinant Cathepsin L assessed as Kinact using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSpike glycoprotein(2019-nCoV)TBA
LigandPNGBDBM50422742(CHEMBL5274408)
Affinity DataIC50:  100nMAssay Description:Binding affinity of SARS-COV2 S-RBD by BLI assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))TBA
LigandPNGBDBM429226(med.21724, Compound 11)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant ACE2 at 50 uM using (7Mca-Y-V-A- D -A-P- K(Knp) as a flurogenic substrate measured after 10 mins by fluorescence base...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))TBA
LigandPNGBDBM429240(med.21724, Compound 12)
Affinity DataIC50:  200nMAssay Description:Inhibition of human recombinant ACE2 at 50 uM using (7Mca-Y-V-A- D -A-P- K(Knp) as a flurogenic substrate measured after 10 mins by fluorescence base...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetStructural capsid protein(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50467395(CHEMBL1229713)
Affinity DataIC50:  220nMAssay Description:Displacement of CPSF6 peptide from HIV1 capsid protein by surface plasmon resonance-based competition assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))TBA
LigandPNGBDBM429241(med.21724, Compound 13)
Affinity DataIC50:  440nMAssay Description:Inhibition of human recombinant ACE2 at 50 uM using (7Mca-Y-V-A- D -A-P- K(Knp) as a flurogenic substrate measured after 10 mins by fluorescence base...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSpike glycoprotein(2019-nCoV)TBA
LigandPNGBDBM50421867(CHEMBL216826)
Affinity DataIC50:  600nMAssay Description:Inhibition of SARS-COV2 spike protein mediated infection of human ACE2 expressing cells at 50 uM by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))TBA
LigandPNGBDBM50421865(CHEMBL5270175)
Affinity DataIC50:  700nMAssay Description:Inhibition of SARS-COV2 S-RBD binding to human ACE2 expressed in HEK293T cells by NanoLuc luciferase assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))TBA
LigandPNGBDBM50467780(CHEBI:5801 | Hydroxychloroquine | acs.jmedchem.1c0...)
Affinity DataIC50:  720nMAssay Description:Inhibition of human recombinant ACE2 at 50 uM using (7Mca-Y-V-A- D -A-P- K(Knp) as a flurogenic substrate measured after 10 mins by fluorescence base...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))TBA
LigandPNGBDBM22985(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
Affinity DataIC50:  1.13E+3nMAssay Description:Inhibition of human recombinant ACE2 at 50 uM using (7Mca-Y-V-A- D -A-P- K(Knp) as a flurogenic substrate measured after 10 mins by fluorescence base...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))TBA
LigandPNGBDBM429290(med.21724, Compound 26)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of human recombinant ACE2More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase ABL2(Homo sapiens (Human))TBA
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of ABL2 (unknown origin) by Nano-syn mobility shift assayMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))TBA
LigandPNGBDBM428874(med.21724, Compound 1)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of SARS-COV2 S-RBD binding to human ACE2 expressed in HEK293T cells by NanoLuc luciferase assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetStructural capsid protein(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50599341(CHEMBL5202526)
Affinity DataIC50:  3.47E+3nMAssay Description:Displacement of NUP153 peptide from HIV1 capsid protein by surface plasmon resonance-based competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSpike glycoprotein(2019-nCoV)TBA
LigandPNGBDBM83797(6-Bromo-4-dimethylaminomethyl-5-hydroxy-1-methyl-2...)
Affinity DataIC50:  4.11E+3nMAssay Description:Inhibition of SARS-COV2 spike protein mediated infection of human ACE2 expressing cells at 50 uM by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSpike glycoprotein(2019-nCoV)TBA
LigandPNGBDBM428875(med.21724, Compound 2)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of SARS-COV2 spike protein mediated infection of human ACE2 expressing cells at 50 uM by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProcathepsin L(Homo sapiens (Human))TBA
LigandPNGBDBM50376204(CHEMBL401925 | med.21724, Compound 23)
Affinity DataIC50:  5.33E+3nMAssay Description:Inhibition of human recombinant Cathepsin L assessed as Kinact using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))TBA
LigandPNGBDBM50422742(CHEMBL5274408)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of human wild type full length ACE2 peptide assessed as inhibitionMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetStructural capsid protein(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50467395(CHEMBL1229713)
Affinity DataIC50:  8.93E+3nMAssay Description:Displacement of NUP153 peptide from HIV1 capsid protein by surface plasmon resonance-based competition assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))TBA
LigandPNGBDBM429289(med.21724, Compound 25)
Affinity DataIC50:  9.70E+3nMAssay Description:Inhibition of human recombinant ACE2More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase ABL2(Homo sapiens (Human))TBA
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of ABL2 (unknown origin) by Nano-syn mobility shift assayMore data for this Ligand-Target Pair
TargetProcathepsin L(Homo sapiens (Human))TBA
LigandPNGBDBM50424712(CAMOSTAT | Camostat Mesilate | Foipan)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human recombinant Cathepsin L assessed as Kinact using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSpike glycoprotein(2019-nCoV)TBA
LigandPNGBDBM7459(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50:  1.06E+4nMAssay Description:Inhibition of SARS-COV2 spike protein mediated infection of human ACE2 expressing cells at 50 uM by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetStructural capsid protein(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50599341(CHEMBL5202526)
Affinity DataIC50:  2.63E+4nMAssay Description:Displacement of CPSF6 peptide from HIV1 capsid protein by surface plasmon resonance-based competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA repair protein RAD51 homolog 1(Homo sapiens (Human))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM48804(3-(phenylmethyl)-2-[(E)-2-(3-pyridinyl)ethenyl]-4-...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of human RAD51-mediated DNA strand exchange at using pBSK (+) gapped and linear dsDNA substrates by joint molecule formation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA repair protein RAD51 homolog 1(Homo sapiens (Human))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM48804(3-(phenylmethyl)-2-[(E)-2-(3-pyridinyl)ethenyl]-4-...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of human RAD51-mediated DNA branch migration using [32P]-labeled 5'-joint molecules after 8 hrs by branch migration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))TBA
LigandPNGBDBM50421872(CHEMBL5284169)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of human wild type full length ACE2 peptide assessed as inhibitionMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))TBA
LigandPNGBDBM50233798(CHEMBL398940 | N-(2-aminoethyl)-1-aziridine-ethana...)
Affinity DataIC50:  5.70E+4nMAssay Description:Inhibition of human recombinant ACE2 at 50 uM using (7Mca-Y-V-A- D -A-P- K(Knp) as a flurogenic substrate measured after 10 mins by fluorescence base...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetStructural capsid protein(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50490577(CHEMBL497058)
Affinity DataIC50:  6.00E+4nMAssay Description:Inhibition of HIV1 capsidMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))TBA
LigandPNGBDBM50421868(CHEMBL5270779)
Affinity DataIC50:  7.50E+4nMAssay Description:Inhibition of human recombinant Cathepsin L assessed as Kinact using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSpike glycoprotein(2019-nCoV)TBA
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Affinity DataIC50:  8.34E+4nMAssay Description:Inhibition of SARS-COV2 spike protein mediated infection of human ACE2 expressing cells at 50 uM by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))TBA
LigandPNGBDBM11318(1,3,8-trihydroxy-6-methyl-9,10-dihydroanthracene-9...)
Affinity DataIC50:  2.00E+5nMAssay Description:Inhibition of human recombinant ACE2More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetStructural capsid protein(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50467394(CHEMBL4279975)
Affinity DataKd:  2.82E+4nMAssay Description:Binding affinity to HIV1 NL4-3 N-terminal domain capsid protein by surface plasmon resonanceMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetStructural capsid protein(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50467395(CHEMBL1229713)
Affinity DataKd:  3.60E+3nMAssay Description:Binding affinity to HIV1 NL4-3 N-terminal domain capsid protein by surface plasmon resonanceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStructural capsid protein(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50467394(CHEMBL4279975)
Affinity DataKd:  1.27E+4nMAssay Description:Binding affinity to HIV1 NL4-3 monomeric capsid protein by surface plasmon resonanceMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetStructural capsid protein(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50467395(CHEMBL1229713)
Affinity DataKd:  2.70E+3nMAssay Description:Binding affinity to HIV1 NL4-3 monomeric capsid protein by surface plasmon resonanceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStructural capsid protein(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50467395(CHEMBL1229713)
Affinity DataKd:  64nMAssay Description:Binding affinity to HIV1 NL4-3 hexameric capsid protein by surface plasmon resonanceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStructural capsid protein(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50467392(CHEMBL4287882)
Affinity DataKd:  2.41E+4nMAssay Description:Binding affinity to HIV1 NL4-3 hexameric capsid protein by surface plasmon resonanceMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetStructural capsid protein(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50467393(CHEMBL4278296)
Affinity DataKd:  1.40E+4nMAssay Description:Binding affinity to HIV1 NL4-3 monomeric capsid protein by surface plasmon resonanceMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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