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Found 402 with Last Name = 'asai' and Initial = 'm'
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM29986(arylpyrazole, 31)
Affinity DataIC50:  0.520nM EC50:  0.310nMAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM29994(2-Cyclohexylcarbonylbenzimidazole, 7e)
Affinity DataIC50:  0.800nM EC50:  2.40nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM29988(benzimidazole analogue, 7h | benzimidazole derivat...)
Affinity DataIC50:  0.810nM EC50:  1.30nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM29988(benzimidazole analogue, 7h | benzimidazole derivat...)
Affinity DataIC50:  0.810nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM30012(benzimidazole analogue, 7k)
Affinity DataIC50:  1nM EC50:  1.10nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM29985(arylpyrazole, 30)
Affinity DataIC50:  1.10nM EC50:  1.20nMAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM30017(benzimidazole analogue, 7p)
Affinity DataIC50:  1.10nM EC50:  0.590nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM50296914((1S,3R)-N-((2-(3-chloropyridin-2-yl)-5-isopropyl-1...)
Affinity DataIC50:  1.40nMAssay Description:Displacement of [125I]Tyr14-nociceptin from human ORL1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM29992(2-Cyclohexylcarbonylbenzimidazole, 7c)
Affinity DataIC50:  1.40nM EC50:  1.30nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM30011(benzimidazole analogue, 7j)
Affinity DataIC50:  1.40nM EC50:  0.550nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  1.60nMAssay Description:Binding affinity for estrogen receptor, by competition with [3H]estradiolMore data for this Ligand-Target Pair
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM30016(benzimidazole analogue, 7o)
Affinity DataIC50:  1.70nM EC50:  0.910nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM30018(benzimidazole analogue, 7q)
Affinity DataIC50:  1.80nM EC50:  7.10nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM30008(benzimidazole analogue, 7g)
Affinity DataIC50:  1.90nM EC50:  1.10nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM391797(6-((7-(3-Chloro-4-cyanophenyl)-5,6,7,8-tetrahydrop...)
Affinity DataIC50:  2nMAssay Description:Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM29990(2-Cyclohexylcarbonylbenzimidazole, 7b)
Affinity DataIC50:  2nM EC50:  5.30nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM30010(benzimidazole analogue, 7i)
Affinity DataIC50:  2.10nM EC50:  1.80nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM30014(benzimidazole analogue, 7m)
Affinity DataIC50:  2.20nM EC50:  0.900nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM50296912((1S,3R)-N-((2-(3-chloropyridin-2-yl)-5-ethyl-1-(6-...)
Affinity DataIC50:  2.30nMAssay Description:Antagonist activity at human cloned ORL1 receptor expressed in CHO cells assessed as inhibition of nociceptin/orphanin FQ-stimulated [35S]GTPgammaS b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM50296914((1S,3R)-N-((2-(3-chloropyridin-2-yl)-5-isopropyl-1...)
Affinity DataIC50:  2.30nMAssay Description:Antagonist activity at human cloned ORL1 receptor expressed in CHO cells assessed as inhibition of nociceptin/orphanin FQ-stimulated [35S]GTPgammaS b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM29987(benzimidazole analogue, 7e | benzimidazole derivat...)
Affinity DataIC50:  2.40nM EC50:  0.720nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM29987(benzimidazole analogue, 7e | benzimidazole derivat...)
Affinity DataIC50:  2.40nM EC50:  0.720nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM29983(arylpyrazole, 28)
Affinity DataIC50:  2.5nM EC50:  1nMAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM29995(CHEMBL494350 | benzimidazole-based antagonist, 1)
Affinity DataIC50:  2.60nM EC50:  0.650nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM50296912((1S,3R)-N-((2-(3-chloropyridin-2-yl)-5-ethyl-1-(6-...)
Affinity DataIC50:  3.20nMAssay Description:Displacement of [125I]Tyr14-nociceptin from human ORL1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Kyoto Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50141551(5-[(S)-3-((S)-2-{(S)-2-[2-Amino-3-((S)-carboxyamin...)
Affinity DataIC50:  3.40nMAssay Description:Inhibitory concentration of compound against Beta-secretase 1 was evaluatedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 9(Homo sapiens (Human))
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50033123(CHEMBL3356618)
Affinity DataIC50:  3.5nMAssay Description:Antagonist activity at human TLR9 transfected in HEK293 cells after 6 hrs by NF-kappaB luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM50296911((1S,3R)-N-((2-(3-chloropyridin-2-yl)-5-methyl-1-(6...)
Affinity DataIC50:  3.70nMAssay Description:Antagonist activity at human cloned ORL1 receptor expressed in CHO cells assessed as inhibition of nociceptin/orphanin FQ-stimulated [35S]GTPgammaS b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 9(Homo sapiens (Human))
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50033119(CHEMBL3357062)
Affinity DataIC50:  3.90nMAssay Description:Antagonist activity at human TLR9 transfected in HEK293 cells after 6 hrs by NF-kappaB luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM29974(arylpyrazole, 19)
Affinity DataIC50:  4nM EC50:  4.70nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM30004(benzimidazole analogue, 7c)
Affinity DataIC50:  4.30nM EC50:  1.10nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM50296915((1S,3R)-N-((1-(3,5-difluorophenyl)-5-isopropyl-2-m...)
Affinity DataIC50:  4.5nMAssay Description:Antagonist activity at human cloned ORL1 receptor expressed in CHO cells assessed as inhibition of nociceptin/orphanin FQ-stimulated [35S]GTPgammaS b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 9(Homo sapiens (Human))
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50033101(CHEMBL2144205)
Affinity DataIC50:  4.60nMAssay Description:Antagonist activity at human TLR9 transfected in HEK293 cells after 6 hrs by NF-kappaB luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM50296913(CHEMBL561396 | N-((2-(3-chloropyridin-2-yl)-5-isop...)
Affinity DataIC50:  4.70nMAssay Description:Displacement of [125I]Tyr14-nociceptin from human ORL1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM50296930((1S,3R)-N-((5-(4-chlorophenyl)-1-isopropyl-4-(2-me...)
Affinity DataIC50:  5.60nMAssay Description:Antagonist activity at human cloned ORL1 receptor expressed in CHO cells assessed as inhibition of nociceptin/orphanin FQ-stimulated [35S]GTPgammaS b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM29989(2-Cyclohexylcarbonylbenzimidazole, 7a)
Affinity DataIC50:  5.70nM EC50:  7.5nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM30013(benzimidazole analogue, 7l)
Affinity DataIC50:  6.90nM EC50:  4nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM30015(benzimidazole analogue, 7n)
Affinity DataIC50:  7.40nM EC50:  3.70nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM50296930((1S,3R)-N-((5-(4-chlorophenyl)-1-isopropyl-4-(2-me...)
Affinity DataIC50:  7.60nMAssay Description:Displacement of [125I]Tyr14-nociceptin from human ORL1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM29981(arylpyrazole, 26)
Affinity DataIC50:  8.20nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 9(Homo sapiens (Human))
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50033108(CHEMBL3357064)
Affinity DataIC50:  8.60nMAssay Description:Antagonist activity at human TLR9 transfected in HEK293 cells after 6 hrs by NF-kappaB luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM50296915((1S,3R)-N-((1-(3,5-difluorophenyl)-5-isopropyl-2-m...)
Affinity DataIC50:  8.60nMAssay Description:Displacement of [125I]Tyr14-nociceptin from human ORL1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM50296911((1S,3R)-N-((2-(3-chloropyridin-2-yl)-5-methyl-1-(6...)
Affinity DataIC50:  9.10nMAssay Description:Displacement of [125I]Tyr14-nociceptin from human ORL1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM29996(benzimidazole analogue, 5a)
Affinity DataIC50:  9.20nM EC50:  2.90nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM29984(arylpyrazole, 29)
Affinity DataIC50:  9.30nM EC50:  4.5nMAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM30005(benzimidazole analogue, 7d)
Affinity DataIC50:  9.5nM EC50:  2.10nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM50296913(CHEMBL561396 | N-((2-(3-chloropyridin-2-yl)-5-isop...)
Affinity DataIC50:  9.60nMAssay Description:Antagonist activity at human cloned ORL1 receptor expressed in CHO cells assessed as inhibition of nociceptin/orphanin FQ-stimulated [35S]GTPgammaS b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM29991(2-Cyclohexylcarbonylbenzimidazole, 9)
Affinity DataIC50:  9.90nM EC50:  38nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM50296929(CHEMBL562663 | N-((5-(4-chlorophenyl)-1-isopropyl-...)
Affinity DataIC50:  11nMAssay Description:Displacement of [125I]Tyr14-nociceptin from human ORL1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Pharmaceutical

LigandPNGBDBM29973(arylpyrazole, 18)
Affinity DataIC50:  11nM EC50:  12nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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