Compile Data Set for Download or QSAR
maximum 50k data
Found 516 with Last Name = 'bryant' and Initial = 'j'
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM81917(BX-2819)
Affinity DataIC50:  0.0400nMpH: 7.4Assay Description:To assess the affinity of compounds binding to Hsp90, we measured their ability to compete with the binding of a fluorescent analog of GA (GM-Bodipy)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077930(5-{5-[4-Benzo[1,3]dioxol-5-yl-2-hydroxy-2-(4-metho...)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18012(trans,trans-4-arylpiperidine-based compound, 1)
Affinity DataIC50:  0.0670nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077933(4-{5-[4-Benzo[1,3]dioxol-5-yl-2-hydroxy-2-(4-metho...)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM81914(Ethyl carbamate analog, 3)
Affinity DataIC50:  0.100nMpH: 7.4Assay Description:To assess the affinity of compounds binding to Hsp90, we measured their ability to compete with the binding of a fluorescent analog of GA (GM-Bodipy)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM81916(lspropyl analog, 5)
Affinity DataIC50:  0.100nMpH: 7.4Assay Description:To assess the affinity of compounds binding to Hsp90, we measured their ability to compete with the binding of a fluorescent analog of GA (GM-Bodipy)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50328726((2R,4R)-N1-(4-chlorophenyl)-N2-(3-fluoro-2'-(methy...)
Affinity DataIC50:  0.160nMAssay Description:FXa inhibition were determined by using an inhibition assay.More data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18033(Ketopiperazine-based inhibitor, 13)
Affinity DataIC50:  0.180nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077934(3-Benzo[1,3]dioxol-5-yl-4-[3,4-dimethoxy-5-(2-morp...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077935(CHEMBL308646 | {5-[4-Benzo[1,3]dioxol-5-yl-2-hydro...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM81915(Ethyl analog, 4)
Affinity DataIC50:  0.200nMpH: 7.4Assay Description:To assess the affinity of compounds binding to Hsp90, we measured their ability to compete with the binding of a fluorescent analog of GA (GM-Bodipy)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077936(4-{5-[4-Benzo[1,3]dioxol-5-yl-2-hydroxy-2-(4-metho...)
Affinity DataIC50:  0.290nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM81912(DC23 | Resorcinol analog, 1)
Affinity DataIC50:  0.300nMpH: 7.4Assay Description:To assess the affinity of compounds binding to Hsp90, we measured their ability to compete with the binding of a fluorescent analog of GA (GM-Bodipy)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077946(5-{5-[4-Benzo[1,3]dioxol-5-yl-2-hydroxy-2-(4-metho...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM17967(CHEMBL411885 | Ketopiperazine-based compound, 16 |...)
Affinity DataIC50:  0.300nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034267(3-(benzo[d][1,3]dioxol-5-yl)-5-hydroxy-5-(4-methox...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077944(CHEMBL408055 | Sodium; 3-{5-[4-benzo[1,3]dioxol-5-...)
Affinity DataIC50:  0.380nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50328728((2R,4R)-N1-(4-chlorophenyl)-N2-(3-fluoro-2'-(methy...)
Affinity DataIC50:  0.380nMAssay Description:FXa inhibition were determined by using an inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM17967(CHEMBL411885 | Ketopiperazine-based compound, 16 |...)
Affinity DataIC50:  0.400nMAssay Description:Inhibitory activity against renin in fluorescent tGFP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18025(2-(7-{[(2R)-1-(4-{3-[(2-methoxyphenyl)methoxy]prop...)
Affinity DataIC50:  0.420nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM17965(N-[2-(7-{[(2R)-1-(4-{3-[(2-methoxyphenyl)methoxy]p...)
Affinity DataIC50:  0.5nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM81913(Unsubstituted phenyl ring analog, 2)
Affinity DataIC50:  0.5nMpH: 7.4Assay Description:To assess the affinity of compounds binding to Hsp90, we measured their ability to compete with the binding of a fluorescent analog of GA (GM-Bodipy)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18032(Ketopiperazine-based inhibitor, 12)
Affinity DataIC50:  0.680nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077941(3-Benzo[1,3]dioxol-5-yl-4-[3,4-dimethoxy-5-(3-morp...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

LigandPNGBDBM81692(4-Substituted Pyrrolidine Ring, 14)
Affinity DataIC50:  0.75nMAssay Description:FXa inhibition were determined by using an inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM17996(1,4-benzoxazin-3-one, 33 | N-{2-[(2S)-6-(2,4-diami...)
Affinity DataIC50:  0.800nMAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077943(3-Benzo[1,3]dioxol-5-yl-4-[3-(3-dimethylamino-prop...)
Affinity DataIC50:  1nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

LigandPNGBDBM81698(4-Substituted Pyrrolidine Ring, 35)
Affinity DataIC50:  1nMAssay Description:FXa inhibition were determined by using an inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM17989(1,4-benzoxazin-3-one, 26 | N-{2-[6-(2,4-diamino-6-...)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

LigandPNGBDBM81693(4-Substituted Pyrrolidine Ring, 16 | 4-Substituted...)
Affinity DataIC50:  1.20nMAssay Description:FXa inhibition were determined by using an inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50328726((2R,4R)-N1-(4-chlorophenyl)-N2-(3-fluoro-2'-(methy...)
Affinity DataIC50:  1.70nMAssay Description:FXa inhibition were determined by using an inhibition assay.More data for this Ligand-Target Pair
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077947(3-Benzo[1,3]dioxol-5-yl-5-hydroxy-5-(4-methoxy-phe...)
Affinity DataIC50:  2nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18005(1,4-benzoxazin-3-one, 42 | methyl N-{2-[6-(2,4-dia...)
Affinity DataIC50:  2nMAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase N catalytic chain(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50201438((+/-)-5-guanidino-2-(mercaptomethyl)pentanoic acid...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human carboxypeptidase NMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077938(3-Benzo[1,3]dioxol-5-yl-4-{3,4-dimethoxy-5-[3-(4-m...)
Affinity DataIC50:  2nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077945(3-Benzo[1,3]dioxol-5-yl-4-[3-(2-dimethylamino-etho...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

LigandPNGBDBM81695(4-Substituted Pyrrolidine Ring, 20)
Affinity DataIC50:  2.90nMAssay Description:FXa inhibition were determined by using an inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Sus scrofa)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50201429(2-(1-carbamimidoylpiperidin-3-yl)-3-mercaptopropan...)
Affinity DataIC50:  3nMAssay Description:Inhibition of porcine pancreatic carboxypeptidase BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18001(1,4-benzoxazin-3-one, 38 | N-{2-[6-(2,4-diamino-6-...)
Affinity DataIC50:  3nMAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17048(Indolinone based inhibitor, 4j | [(3Z)-2-oxo-3-[1-...)
Affinity DataIC50:  3nMAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17014(Indolinone based compound, 22 | N-[(5-{1-[(3Z)-5-(...)
Affinity DataIC50:  3nMAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17003(Indolinone based compound, 7l | [(3Z)-3-({4-[3-(am...)
Affinity DataIC50:  3nMAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Sus scrofa)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50201429(2-(1-carbamimidoylpiperidin-3-yl)-3-mercaptopropan...)
Affinity DataIC50:  3nMAssay Description:Inhibition of porcine pancreatic carboxypeptidase BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18028((6R)-1-(4-{3-[(2-methoxyphenyl)methoxy]propoxy}phe...)
Affinity DataIC50:  3.20nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077942(3-Benzo[1,3]dioxol-5-yl-5-hydroxy-5-(4-methoxy-phe...)
Affinity DataIC50:  4nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Staphylococcus aureus)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50358854(CHEMBL1923440)
Affinity DataIC50:  4nMAssay Description:Inhibition of ATPase activity of recombinant Staphylococcus aureus DNA gyrase B hybrid tetramer enzyme reconstituted from Escherichia coli GyrA by am...More data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18022(Ketopiperazine-based inhibitor, 2)
Affinity DataIC50:  4nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM16996(3-(5-{[(3Z)-5-(carbamoylamino)-2-oxo-2,3-dihydro-1...)
Affinity DataIC50:  4nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM16995(3-(5-{[(3Z)-5-(carbamoylamino)-2-oxo-2,3-dihydro-1...)
Affinity DataIC50:  4nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17010(Indolinone based compound, 18 | N-[(5-{1-[(3Z)-5-(...)
Affinity DataIC50:  4nMAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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