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Found 193 with Last Name = 'croll' and Initial = 'd'
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162995(3-[1-(1,2-Dihydro-pyridin-2-yl)-1H-indazol-3-yl]-4...)
Affinity DataKi:  11nMAssay Description:Inhibition of Potassium channel HERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162996(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-[...)
Affinity DataKi:  25nMAssay Description:Inhibition of Potassium channel HERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162990(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataKi:  34nMAssay Description:Inhibition of Potassium channel HERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50163000(3-(1-Piperazin-1-yl-1H-indazol-3-yl)-4-[1-(1,4,4a,...)
Affinity DataKi:  290nMAssay Description:Inhibition of Potassium channel HERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50017376((+/-)1-(4-tert-butylphenyl)-4-(4-(hydroxydiphenylm...)
Affinity DataKi:  320nMAssay Description:Inhibition of Potassium channel HERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162992(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataKi:  490nMAssay Description:Inhibition of Potassium channel HERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162993(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataKi:  610nMAssay Description:Inhibition of Potassium channel HERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50163002(3-(1-Morpholin-2-yl-1H-indazol-3-yl)-4-[1-(1,4,4a,...)
Affinity DataKi:  850nMAssay Description:Inhibition of Potassium channel HERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Platelet-derived growth factor receptor in P19 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162990(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataIC50:  4nMAssay Description:Inhibition of IL-8 release by HEK293 cells expressing PKC-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147472(3-[1-(3-Hydroxy-propyl)-1H-pyrrolo[2,3-b]pyridin-3...)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration against rabbit glycogen synthase kinase-3 beta using protein phosphatase inhibitor-2 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162996(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-[...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human Protein kinase C beta 2 using [gamma-33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147465(3-(2-Chloro-4-fluoro-phenyl)-4-[1-(3-hydroxy-propy...)
Affinity DataIC50:  6nMAssay Description:Inhibitory concentration against rabbit glycogen synthase kinase-3 beta using protein phosphatase inhibitor-2 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147458((3-{3-[4-(2-Methoxy-phenyl)-2,5-dioxo-2,5-dihydro-...)
Affinity DataIC50:  7nMAssay Description:Inhibitory concentration against rabbit glycogen synthase kinase-3 beta using protein phosphatase inhibitor-2 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162993(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human Protein kinase C beta 2 using [gamma-33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162990(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human Protein kinase C beta 1 using [gamma-33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147464(CHEMBL109977 | N-(3-{3-[4-(2-Methoxy-phenyl)-2,5-d...)
Affinity DataIC50:  8nMAssay Description:Inhibitory concentration against rabbit glycogen synthase kinase-3 beta using protein phosphatase inhibitor-2 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Mus musculus)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  8nMAssay Description:Inhibition of Cyclin-dependent kinase 1 in P19 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human Protein kinase C beta 2 using [gamma-33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147473(3-(2-Chloro-phenyl)-4-[1-(3-hydroxy-propyl)-1H-pyr...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration against rabbit glycogen synthase kinase-3 beta using protein phosphatase inhibitor-2 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162998(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human Protein kinase C beta 2 using [gamma-33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162990(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human Protein kinase C alpha using [gamma-33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50163001(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataIC50:  13nMAssay Description:Inhibition of IL-8 release by HEK293 cells expressing PKC-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147461(3-[1-(3-Hydroxy-propyl)-1H-pyrrolo[2,3-b]pyridin-3...)
Affinity DataIC50:  14nMAssay Description:Inhibitory concentration against rabbit glycogen synthase kinase-3 beta using protein phosphatase inhibitor-2 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147459(CHEMBL326208 | N-(3-{3-[4-(2-Methoxy-phenyl)-2,5-d...)
Affinity DataIC50:  14nMAssay Description:Inhibitory concentration against rabbit glycogen synthase kinase-3 beta using protein phosphatase inhibitor-2 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162998(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human Protein kinase C beta 1 using [gamma-33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162992(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human Protein kinase C beta 2 using [gamma-33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147462(3-(2-Chloro-phenyl)-4-[1-(3-dimethylamino-propyl)-...)
Affinity DataIC50:  15nMAssay Description:Inhibitory concentration against rabbit glycogen synthase kinase-3 beta using protein phosphatase inhibitor-2 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50163002(3-(1-Morpholin-2-yl-1H-indazol-3-yl)-4-[1-(1,4,4a,...)
Affinity DataIC50:  18nMAssay Description:Inhibition of IL-8 release by HEK293 cells expressing PKC-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162993(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human Protein kinase C beta 1 using [gamma-33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147468(3-(7-Azaindolyl)-4-arylmaleimide analogue | CHEMBL...)
Affinity DataIC50:  20nMAssay Description:Inhibitory concentration against rabbit glycogen synthase kinase-3 beta using protein phosphatase inhibitor-2 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162990(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataIC50:  20nMAssay Description:Inhibition of IL-8 release by HEK293 cells expressing PKC-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162999(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataIC50:  23nMAssay Description:Inhibition of IL-8 release by HEK293 cells expressing PKC-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162996(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-[...)
Affinity DataIC50:  24nMAssay Description:Inhibition of IL-8 release by HEK293 cells expressing PKC-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147463(3-(3-Chloro-5-trifluoromethyl-pyridin-2-yl)-4-[1-(...)
Affinity DataIC50:  26nMAssay Description:Inhibitory concentration against rabbit glycogen synthase kinase-3 beta using protein phosphatase inhibitor-2 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162996(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-[...)
Affinity DataIC50:  28nMAssay Description:Inhibition of Potassium channel HERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human Protein kinase C alpha using [gamma-33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162994(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-[...)
Affinity DataIC50:  29nMAssay Description:Inhibition of human Protein kinase C beta 2 using [gamma-33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162990(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataIC50:  31nMAssay Description:Inhibition of Protein kinase C deltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147469(3-[1-(3-Hydroxy-propyl)-1H-pyrrolo[2,3-b]pyridin-3...)
Affinity DataIC50:  31nMAssay Description:Inhibitory concentration against rabbit glycogen synthase kinase-3 beta using protein phosphatase inhibitor-2 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147471(3-[1-(3-Hydroxy-propyl)-1H-pyrrolo[2,3-b]pyridin-3...)
Affinity DataIC50:  31nMAssay Description:Inhibitory concentration against rabbit glycogen synthase kinase-3 beta using protein phosphatase inhibitor-2 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162996(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-[...)
Affinity DataIC50:  33nMAssay Description:Inhibition of human Protein kinase C beta 1 using [gamma-33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162991(3-(1-Benzo[b]thiophen-2-yl-1H-indol-3-yl)-4-[1-(3-...)
Affinity DataIC50:  37nMAssay Description:Inhibition of human Protein kinase C beta 2 using [gamma-33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147460(3-[1-(3-Amino-propyl)-1H-pyrrolo[2,3-b]pyridin-3-y...)
Affinity DataIC50:  37nMAssay Description:Inhibitory concentration against rabbit glycogen synthase kinase-3 beta using protein phosphatase inhibitor-2 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162995(3-[1-(1,2-Dihydro-pyridin-2-yl)-1H-indazol-3-yl]-4...)
Affinity DataIC50:  44nMAssay Description:Inhibition of human Protein kinase C beta 2 using [gamma-33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147457(3-(2-Hydroxy-phenyl)-4-[1-(3-hydroxy-propyl)-1H-py...)
Affinity DataIC50:  45nMAssay Description:Inhibitory concentration against rabbit glycogen synthase kinase-3 beta using protein phosphatase inhibitor-2 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50163001(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataIC50:  46nMAssay Description:Inhibition of human Protein kinase C beta 1 using [gamma-33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C gamma type(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162990(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataIC50:  47nMAssay Description:Inhibition of human Protein kinase C gamma using [gamma-33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162999(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataIC50:  49nMAssay Description:Inhibition of rabbit Glycogen synthase kinase-3 betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  49nMAssay Description:Inhibition of Protein kinase C deltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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