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Found 2162 with Last Name = 'frie' and Initial = 'j'
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50000296(CHEMBL441765 | CHEMBL482811 | U-50488H | US1149237...)
Affinity DataKi:  0.0940nMAssay Description:Displacement of [3H]-U69593 from human kappa opioid receptor expressed in U2OS cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50000296(CHEMBL441765 | CHEMBL482811 | U-50488H | US1149237...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]-U69593 from human kappa opioid receptor expressed in U2OS cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50448583(CHEMBL3127491)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human coagulation factor 11a using p-nitroaniline as substrate assessed as substrate hydrolysis by spectrophotometricallyMore data for this Ligand-Target Pair
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032873(CHEMBL3355684)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human coagulation factor 11a using p-nitroaniline as substrate assessed as substrate hydrolysis by spectrophotometricallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032874(CHEMBL3355683)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human coagulation factor 11a using p-nitroaniline as substrate assessed as substrate hydrolysis by spectrophotometricallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Affinity DataKi:  0.350nMAssay Description:Displacement of [3H]-DAMGO from human mu opioid receptor expressed in CHO-K1 cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Affinity DataKi:  0.350nMAssay Description:Displacement of [3H]-DAMGO from human mu opioid receptor expressed in CHO-K1 cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032874(CHEMBL3355683)
Affinity DataKi:  0.800nMAssay Description:Inhibition of human coagulation factor 11a using p-nitroaniline as substrate assessed as substrate hydrolysis at 37 degC by spectrophotometricallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]-DPDPE from human delta opioid receptor expressed in CHO-K1 cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]-DPDPE from human delta opioid receptor expressed in CHO-K1 cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50448583(CHEMBL3127491)
Affinity DataKi:  2nMAssay Description:Inhibition of human plasma kallikrein using H-D-Pro-Phe-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032873(CHEMBL3355684)
Affinity DataKi:  2nMAssay Description:Inhibition of human plasma kallikrein using H-D-Pro-Phe-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032875(CHEMBL3355682)
Affinity DataKi:  3nMAssay Description:Inhibition of human coagulation factor 11a using p-nitroaniline as substrate assessed as substrate hydrolysis by spectrophotometricallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032876(CHEMBL3355681)
Affinity DataKi:  3nMAssay Description:Inhibition of human coagulation factor 11a using p-nitroaniline as substrate assessed as substrate hydrolysis by spectrophotometricallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50103208(CHEMBL3393381)
Affinity DataKi:  3.20nMAssay Description:Inhibition of human coagulation factor 11a after 10 to 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50103201(CHEMBL3393388)
Affinity DataKi:  3.70nMAssay Description:Inhibition of human coagulation factor 11a after 10 to 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032877(CHEMBL3355680)
Affinity DataKi:  4nMAssay Description:Inhibition of human coagulation factor 11a using p-nitroaniline as substrate assessed as substrate hydrolysis by spectrophotometricallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24198(3-aminopropylphosphinic derivative, (R)-8 | [(2R)-...)
Affinity DataKi:  4.30nM ΔG°:  -47.3kJ/mole EC50:  14nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032874(CHEMBL3355683)
Affinity DataKi:  5nMAssay Description:Inhibition of human plasma kallikrein using H-D-Pro-Phe-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24195(3-aminopropylphosphinic derivative, (R)-7 | AZD335...)
Affinity DataKi:  5.10nM ΔG°:  -46.9kJ/mole EC50:  8.64nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032876(CHEMBL3355681)
Affinity DataKi:  8nMAssay Description:Inhibition of human plasma kallikrein using H-D-Pro-Phe-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50103200(CHEMBL3393386)
Affinity DataKi:  8.40nMAssay Description:Inhibition of human coagulation factor 11a after 10 to 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032878(CHEMBL3355679)
Affinity DataKi:  9nMAssay Description:Inhibition of human coagulation factor 11a using p-nitroaniline as substrate assessed as substrate hydrolysis by spectrophotometricallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24193((3-amino-2-fluoropropyl)phosphinic acid | 3-aminop...)
Affinity DataKi:  10nM ΔG°:  -45.2kJ/mole EC50:  15nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50103216(CHEMBL3393373)
Affinity DataKi:  12nMAssay Description:Inhibition of human coagulation factor 11a after 10 to 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50103204(CHEMBL3393385)
Affinity DataKi:  13nMAssay Description:Inhibition of human coagulation factor 11a after 10 to 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24196((3-amino-2-fluoropropyl)(methyl)phosphinic acid | ...)
Affinity DataKi:  14nM ΔG°:  -44.4kJ/mole EC50:  23nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24184((3-aminopropyl)phosphinic acid | 3-aminopropylphos...)
Affinity DataKi:  15nM ΔG°:  -44.2kJ/mole EC50:  19nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032877(CHEMBL3355680)
Affinity DataKi:  20nMAssay Description:Inhibition of human plasma kallikrein using H-D-Pro-Phe-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50103206(CHEMBL3393383)
Affinity DataKi:  21nMAssay Description:Inhibition of human coagulation factor 11a after 10 to 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypsin(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032874(CHEMBL3355683)
Affinity DataKi:  23nMAssay Description:Inhibition of human coagulation trypsin using N-benzoyl-Ile-Glu-(OH, OMe)-Gly-Arg-pNA as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50103200(CHEMBL3393386)
Affinity DataKi:  24nMAssay Description:Inhibition of human plasma kallikreinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032858(CHEMBL3355670)
Affinity DataKi:  30nMAssay Description:Inhibition of human coagulation factor 11a using p-nitroaniline as substrate assessed as substrate hydrolysis by spectrophotometricallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24185((3-aminopropyl)(methyl)phosphinic acid | 3-Apmpa |...)
Affinity DataKi:  33nM ΔG°:  -42.3kJ/mole EC50:  41nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetCannabinoid receptor 2(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM60994((10R,10aR)-6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tet...)
Affinity DataKi:  36nMAssay Description:Displacement of [3H]CP-55,940 from human CB2 receptor expressed in CHO cells incubated for 1 hr by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCannabinoid receptor 1(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM60994((10R,10aR)-6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tet...)
Affinity DataKi:  41nMAssay Description:Displacement of [3H]CP-55,940 from human CB1 receptor expressed in CHO cells incubated for 1 hr by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50103207(CHEMBL3393382)
Affinity DataKi:  42nMAssay Description:Inhibition of human coagulation factor 11a after 10 to 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032878(CHEMBL3355679)
Affinity DataKi:  45nMAssay Description:Inhibition of human plasma kallikrein using H-D-Pro-Phe-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24191((3-amino-2-oxopropyl)phosphinic acid | (3-amino-2-...)
Affinity DataKi:  48nM ΔG°:  -41.4kJ/mole EC50:  81nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM24186((3-amino-2-hydroxypropyl)phosphinic acid | 3-amino...)
Affinity DataKi:  50nM ΔG°:  -41.3kJ/mole EC50:  130nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032875(CHEMBL3355682)
Affinity DataKi:  50nMAssay Description:Inhibition of human plasma kallikrein using H-D-Pro-Phe-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032858(CHEMBL3355670)
Affinity DataKi:  60nMAssay Description:Inhibition of human plasma kallikrein using H-D-Pro-Phe-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypsin(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50103200(CHEMBL3393386)
Affinity DataKi:  64nMAssay Description:Inhibition of human trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24194(3-aminopropylphosphinic derivative, (S)-7 | [(2S)-...)
Affinity DataKi:  70nM ΔG°:  -40.4kJ/mole EC50:  250nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50292340(AKUAMMICINE | CHEMBL508955)
Affinity DataKi:  89nMAssay Description:Displacement of [3H]-U69593 from human kappa opioid receptor expressed in U2OS cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50292340(AKUAMMICINE | CHEMBL508955)
Affinity DataKi:  89nMAssay Description:Displacement of [3H]-U69593 from human kappa opioid receptor expressed in U2OS cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24186((3-amino-2-hydroxypropyl)phosphinic acid | 3-amino...)
Affinity DataKi:  94nM ΔG°:  -39.7kJ/mole EC50:  220nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50103211(CHEMBL3393378)
Affinity DataKi:  113nMAssay Description:Inhibition of human coagulation factor 11a after 10 to 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032866(CHEMBL3355664)
Affinity DataKi:  120nMAssay Description:Inhibition of human coagulation factor 11a using p-nitroaniline as substrate assessed as substrate hydrolysis by spectrophotometricallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50103366(CHEMBL3393362)
Affinity DataKi:  120nMAssay Description:Inhibition of human coagulation factor 11a after 10 to 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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