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Found 228 with Last Name = 'ghate' and Initial = 'm'
LigandPNGBDBM50608974(CHEMBL5288856)
Affinity DataIC50:  0.0600nMAssay Description:Inhibition of PDE10A (unknown origin)More data for this Ligand-Target Pair
Ligand Info
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LigandPNGBDBM50608972(CHEMBL5266334)
Affinity DataIC50:  0.0600nMAssay Description:Inhibition of PDE10A (unknown origin)More data for this Ligand-Target Pair
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TargetHistone deacetylase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50165469(CHEMBL3797911)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of c-Met (unknown origin) using poly(Glu-Tyr) at 4:1 ratio as substrate in presence of ATP incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50608973(CHEMBL4563588)
Affinity DataIC50:  0.140nMAssay Description:Inhibition of PDE10A (unknown origin)More data for this Ligand-Target Pair
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))TBA
LigandPNGBDBM50035620(CHEMBL3338445)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair
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LigandPNGBDBM50608971(CHEMBL5290355)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of PDE10A (unknown origin)More data for this Ligand-Target Pair
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TargetHistone deacetylase 2(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataIC50:  0.330nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataIC50:  0.370nMAssay Description:Inhibition of HDAC11 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataIC50:  0.460nMAssay Description:Inhibition of HDAC10 (unknown origin)More data for this Ligand-Target Pair
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LigandPNGBDBM50608964(CHEMBL5271175)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of PDE10A (unknown origin)More data for this Ligand-Target Pair
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TargetHistone deacetylase 4(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataIC50:  0.640nMAssay Description:Inhibition of HDAC4 (unknown origin)More data for this Ligand-Target Pair
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LigandPNGBDBM290889(1-[2-fluoro-4- (tetrahydro-2H- pyran-4-yl)phenyl]-...)
Affinity DataIC50:  0.770nMAssay Description:Inhibition of PDE10A (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341366(6-(2,4-Difluorophenoxy)-8-(1,1-dioxo-hexahydro-thi...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341370(6-(2,4-Difluorophenoxy)-8-(1-methanesulfonyl-piper...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341361(6-(2,4-Difluorophenoxy)-8-ethyl-2-(tetrahydro-2H-p...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341350(2-(1-Acetyl-piperidin-4-ylamino)-6-(2,4-difluoroph...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50615563(CHEMBL5273665)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of c-Met (unknown origin) kinase activity using poly(Glu-Tyr) at 4:1 ratio as substrate in presence of ATP incubated for 30 mins by HTRF a...More data for this Ligand-Target Pair
Ligand Info
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TargetHistone deacetylase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
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LigandPNGBDBM50608970(CHEMBL5284754)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of PDE10A (unknown origin)More data for this Ligand-Target Pair
Ligand Info
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TargetHistone deacetylase 3(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM290889(1-[2-fluoro-4- (tetrahydro-2H- pyran-4-yl)phenyl]-...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of PDE10A2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50365964(CHEMBL1956235 | CHEMBL2070530)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of PDE10A (unknown origin)More data for this Ligand-Target Pair
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LigandPNGBDBM50520336(CHEMBL4470042)
Affinity DataIC50:  2nMAssay Description:Inhibition of human PDE10A (449 to 789 residues) expressed in Escherichia coli BL21(DE3) using cAMP as substrate incubated for 30 mins by HTRF analys...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341369(CHEMBL1766506 | [6-(2,4-Difluorophenoxy)-7-oxo-2-(...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341363(6-(2,4-Difluorophenoxy)-8-(3-hydroxy-propyl)-2-(te...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341356(6-(2,4-Difluorophenoxy)-8-methyl-2-((S)-1-methyl-2...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus (HCV))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50301911(CHEMBL583269 | N-{3-[(S)-5-tert-Butyl-1-(4-fluoro-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of HSV 1b con1 NS5B polymerase assessed as [3H]UTP incorporation into acid insoluble RNA productMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLipoxygenase(Glycine max (Soybean))
Nirma University

LigandPNGBDBM192705(7-(2-hydroxy-3-(6-methoxybenzo[d]thiazol-2-ylamino...)
Affinity DataIC50:  2.12nMpH: 9.0 T: 2°CAssay Description:It is determined by kinetic mode of spectro-photometric determination method,which was performed by recording the rate of change in absorbance at 234...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50608294(CHEMBL3949465)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of c-Met (unknown origin) kinase activity using poly(Glu-Tyr) at 4:1 ratio as substrate in presence of ATP incubated for 30 mins by HTRF a...More data for this Ligand-Target Pair
Ligand Info
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TargetLipoxygenase(Glycine max (Soybean))
Nirma University

LigandPNGBDBM192703(7-(3-(6-chlorobenzo[d]thiazol-2-ylamino)-2-hydroxy...)
Affinity DataIC50:  2.79nMpH: 9.0 T: 2°CAssay Description:It is determined by kinetic mode of spectro-photometric determination method,which was performed by recording the rate of change in absorbance at 234...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of HDAC10 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50301902(CHEMBL571825 | N-{3-[(S)-5-tert-Butyl-1-(4-fluoro-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of HSV 1b con1 NS5B polymerase assessed as [3H]UTP incorporation into acid insoluble RNA productMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLipoxygenase(Glycine max (Soybean))
Nirma University

LigandPNGBDBM192701(7-(2-hydroxy-3-(6-nitrobenzo[d]thiazol-2-ylamino)p...)
Affinity DataIC50:  3.24nMpH: 9.0 T: 2°CAssay Description:It is determined by kinetic mode of spectro-photometric determination method,which was performed by recording the rate of change in absorbance at 234...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of HDAC5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50301914(CHEMBL570249 | N-{2-Acetyl-3-[(S)-5-tert-butyl-1-(...)
Affinity DataIC50:  4nMAssay Description:Inhibition of HSV 1b con1 NS5B polymerase assessed as [3H]UTP incorporation into acid insoluble RNA productMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341372(6-(2,4-Difluorophenoxy)-2-isopropylamino-8-methyl-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341352(CHEMBL1766580 | trans-6-(2,4-Difluorophenoxy)-2-(t...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50301903(CHEMBL569120 | N-{3-[(S)-5-tert-Butyl-1-(4-fluoro-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of HSV 1b con1 NS5B polymerase assessed as [3H]UTP incorporation into acid insoluble RNA productMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50615565(CHEMBL4576664)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of c-Met (unknown origin) kinase activity using poly(Glu-Tyr) at 4:1 ratio as substrate in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
Ligand Info
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TargetHistone deacetylase 8(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of HDAC8 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50301901(CHEMBL570934 | N-{3-[(S)-5-tert-Butyl-1-(3-chloro-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of HSV 1b con1 NS5B polymerase assessed as [3H]UTP incorporation into acid insoluble RNA productMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341346((R)-6-(2,4-difluorophenoxy)-8-methyl-2-(1-(methyls...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50:  5nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50301906(CHEMBL571606 | N-{3-[(S)-5-tert-Butyl-4-hydroxy-1-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of HSV 1b con1 NS5B polymerase assessed as [3H]UTP incorporation into acid insoluble RNA productMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM31604(methyl substituted pyrazole, 25)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of PDE10A (unknown origin)More data for this Ligand-Target Pair
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TargetHistone deacetylase 11(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of HDAC11 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50301913(CHEMBL571564 | N-{3-[(S)-5-tert-Butyl-1-(4-fluoro-...)
Affinity DataIC50:  6nMAssay Description:Inhibition of HSV 1b con1 NS5B polymerase assessed as [3H]UTP incorporation into acid insoluble RNA productMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50351632(CHEMBL498769)
Affinity DataIC50:  6nMAssay Description:Inhibition of c-Met (unknown origin) using poly(Glu-Tyr) at 4:1 ratio as substrate in presence of ATP incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails PubMed
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