TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataKi: 153nMAssay Description:Displacement of [3H]methoxyPEPy from rat mGluR5 expressed in human HEK293 cells after 1 hr by scintillation counterMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataKi: 195nMAssay Description:Displacement of [3H]methoxyPEPy from rat mGluR5 expressed in human HEK293 cells after 1 hr by scintillation counterMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]methoxyPEPy from rat mGluR5 expressed in human HEK293 cells after 1 hr by scintillation counterMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Beckman Research Institute
Curated by ChEMBL
Beckman Research Institute
Curated by ChEMBL
Affinity DataIC50: <0.5nMAssay Description:Inhibition of recombinant c-Src (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Beckman Research Institute
Curated by ChEMBL
Beckman Research Institute
Curated by ChEMBL
Affinity DataIC50: <0.5nMAssay Description:Inhibition of recombinant c-Src (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Beckman Research Institute
Curated by ChEMBL
Beckman Research Institute
Curated by ChEMBL
Affinity DataIC50: 0.610nMAssay Description:Inhibition of recombinant Aurora A (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Beckman Research Institute
Curated by ChEMBL
Beckman Research Institute
Curated by ChEMBL
Affinity DataIC50: 0.830nMAssay Description:Inhibition of recombinant c-Src (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 0.870nMAssay Description:Inhibition of recombinant ABL1 (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Beckman Research Institute
Curated by ChEMBL
Beckman Research Institute
Curated by ChEMBL
Affinity DataIC50: 2.20nMAssay Description:Inhibition of recombinant c-Src (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Beckman Research Institute
Curated by ChEMBL
Beckman Research Institute
Curated by ChEMBL
Affinity DataIC50: 3.90nMAssay Description:Inhibition of recombinant c-Src (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Beckman Research Institute
Curated by ChEMBL
Beckman Research Institute
Curated by ChEMBL
Affinity DataIC50: 3.90nMAssay Description:Inhibition of recombinant c-Src (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Beckman Research Institute
Curated by ChEMBL
Beckman Research Institute
Curated by ChEMBL
Affinity DataIC50: 4.90nMAssay Description:Inhibition of recombinant c-Src (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 7.10nMAssay Description:Inhibition of recombinant Aurora A (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 7.20nMAssay Description:Inhibition of recombinant ABL1 (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 7.20nMAssay Description:Inhibition of recombinant ABL1 (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 9.40nMAssay Description:Inhibition of recombinant JAK2 (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant Aurora A (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 34nMAssay Description:Inhibitory constant against Serotonin transporterMore data for this Ligand-Target Pair
Affinity DataIC50: 34.1nMAssay Description:Inhibition of recombinant ABL1 (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 41.5nMAssay Description:Inhibition of recombinant Aurora A (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:Inhibition of recombinant Aurora A (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 67nMAssay Description:Inhibition of recombinant ABL1 (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 79nMAssay Description:Inhibition of recombinant Aurora A (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
Affinity DataIC50: 107nMAssay Description:Inhibition of recombinant ABL1 (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
Affinity DataIC50: 175nMAssay Description:Inhibition of recombinant Aurora A (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 178nMAssay Description:Inhibition of recombinant ABL1 T315I mutant (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Negative allosteric modulation of human mGlu3 expressed in AV-12 cells in presence of glutamate EC90 concentration by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
Affinity DataIC50: 194nMAssay Description:Inhibition of recombinant ABL1 T315I mutant (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Beckman Research Institute
Curated by ChEMBL
Beckman Research Institute
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of recombinant GST-tagged c-Src (unknown origin) expressed in insect cells using pEY as substrate preincubated with enzyme followed by [33...More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
Affinity DataIC50: 224nMAssay Description:Inhibition of recombinant JAK2 (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 240nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataIC50: 270nMAssay Description:Negative allosteric modulation of mGlu3 by cell-based assayMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataIC50: 296nMAssay Description:Negative allosteric modulation of mGlu2 by cell-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
Affinity DataIC50: 320nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
Affinity DataIC50: 330nMAssay Description:Inhibition of recombinant c-Src (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
Affinity DataIC50: 450nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
Affinity DataIC50: 468nMAssay Description:Inhibition of recombinant ABL1 (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 490nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair