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Found 610 with Last Name = 'govek' and Initial = 'sp'
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM368199((S)-2-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)...)
Affinity DataIC50:  0.0700nMAssay Description:MCF-7 cells were adjusted to a concentration of 40,000 cells per mL in RPMI containing 10% FBS and 20 mM HEPES. 16 microliters of the cell suspension...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50508708(CHEMBL4438260)
Affinity DataIC50:  0.100nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ERalpha protein level after 4 hrs by InCell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM368199((S)-2-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)...)
Affinity DataIC50:  0.100nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ERalpha protein level after 4 hrs by InCell Western assayMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50508704(CHEMBL4435067)
Affinity DataIC50:  0.100nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ERalpha protein level after 4 hrs by InCell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50508703(CHEMBL4563316)
Affinity DataIC50:  0.100nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ERalpha protein level after 4 hrs by InCell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM368203(US10227334, Example (S)-3-(3-Hydroxyphenyl)-4-meth...)
Affinity DataIC50:  0.100nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ERalpha protein level after 4 hrs by InCell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50508700(CHEMBL4453442)
Affinity DataIC50:  0.100nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ERalpha protein level after 4 hrs by InCell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM368203(US10227334, Example (S)-3-(3-Hydroxyphenyl)-4-meth...)
Affinity DataIC50:  0.130nMAssay Description:MCF-7 cells were adjusted to a concentration of 40,000 cells per mL in RPMI containing 10% FBS and 20 mM HEPES. 16 microliters of the cell suspension...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50508710(CHEMBL4461269)
Affinity DataIC50:  0.200nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ERalpha protein level after 4 hrs by InCell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50508701(CHEMBL4464718)
Affinity DataIC50:  0.200nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ERalpha protein level after 4 hrs by InCell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50508709(CHEMBL4576272)
Affinity DataIC50:  0.200nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ERalpha protein level after 4 hrs by InCell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50508707(CHEMBL4438992)
Affinity DataIC50:  0.200nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ERalpha protein level after 4 hrs by InCell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50508697(CHEMBL4438826)
Affinity DataIC50:  0.200nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ERalpha protein level after 4 hrs by InCell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM368197((-)-2-(4-(2-(3-(Fluoromethyl)azetidin-1-yl)ethoxy)...)
Affinity DataIC50:  0.210nMAssay Description:MCF-7 cells were adjusted to a concentration of 40,000 cells per mL in RPMI containing 10% FBS and 20 mM HEPES. 16 microliters of the cell suspension...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50508706(CHEMBL4574167)
Affinity DataIC50:  0.300nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ERalpha protein level after 4 hrs by InCell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM368197((-)-2-(4-(2-(3-(Fluoromethyl)azetidin-1-yl)ethoxy)...)
Affinity DataIC50:  0.300nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ERalpha protein level after 4 hrs by InCell Western assayMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50508702(CHEMBL4454014)
Affinity DataIC50:  0.400nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ERalpha protein level after 4 hrs by InCell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50169743((13S,17S)-13-Methyl-7-[9-(4,4,5,5,5-pentafluoro-pe...)
Affinity DataIC50:  0.570nMAssay Description:MCF-7 cells were adjusted to a concentration of 40,000 cells per mL in RPMI containing 10% FBS and 20 mM HEPES. 16 microliters of the cell suspension...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50508705(CHEMBL4450664)
Affinity DataIC50:  0.800nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ERalpha protein level after 4 hrs by InCell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50317611(4-(3,5-dichloropyridin-4-ylamino)-8-(3-(dimethylam...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hrMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50317616(4-(3,5-dichloropyridin-4-ylamino)-8-(8-(dimethylam...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50317610(9-(4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2-o...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50317609(8-(4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2-o...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50317615(4-(3,5-dichloropyridin-4-ylamino)-8-(7-(dimethylam...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM368198((R)-2-(4-(2-(3-(Fluoromethyl)azetidin-1-yl)ethoxy)...)
Affinity DataIC50:  4.30nMAssay Description:MCF-7 cells were adjusted to a concentration of 40,000 cells per mL in RPMI containing 10% FBS and 20 mM HEPES. 16 microliters of the cell suspension...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50317614(4-(3,5-dichloropyridin-4-ylamino)-8-(6-(dimethylam...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50317603(8-(cyclopentyloxy)-4-(3,5-dichloropyridin-4-ylamin...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hrMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50317604(2-(4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2-o...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50368866(CHEMBL4159656)
Affinity DataIC50:  9.70nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ERalpha protein level after 4 hrs by InCell Western assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50508699(CHEMBL4460877)
Affinity DataIC50:  11nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ERalpha protein level after 4 hrs by InCell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM368198((R)-2-(4-(2-(3-(Fluoromethyl)azetidin-1-yl)ethoxy)...)
Affinity DataIC50:  13nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ERalpha protein level after 4 hrs by InCell Western assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50508698(CHEMBL4548012)
Affinity DataIC50:  15nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ERalpha protein level after 4 hrs by InCell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50317608(7-(4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2-o...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50317613(4-(3,5-dichloropyridin-4-ylamino)-8-(5-(dimethylam...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50317607(6-(4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2-o...)
Affinity DataIC50:  43nMAssay Description:Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50317612(4-(3,5-dichloropyridin-4-ylamino)-8-(4-(dimethylam...)
Affinity DataIC50:  45nMAssay Description:Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50317606(5-(4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2-o...)
Affinity DataIC50:  80nMAssay Description:Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase 13(Human)
Fl2022-001

US Patent
LigandPNGBDBM649163(5-(5-(6-Azaspiro[2.5]octan-6-yl)-1H- pyrazolo[3,4-...)
Affinity DataIC50: <100nMAssay Description:HSD17b13 enzyme was diluted in 1× assay buffer to the desired enzyme concentration based on the specific activity of the enzyme lot. 20 uL of diluted...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target17-beta-hydroxysteroid dehydrogenase 13(Human)
Fl2022-001

US Patent
LigandPNGBDBM648915(5-(5-(3-Chloro-4-hydroxyphenyl)-1H-indazol- 1-yl)-...)
Affinity DataIC50: <100nMAssay Description:HSD17b13 enzyme was diluted in 1× assay buffer to the desired enzyme concentration based on the specific activity of the enzyme lot. 20 uL of diluted...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target17-beta-hydroxysteroid dehydrogenase 13(Human)
Fl2022-001

US Patent
LigandPNGBDBM649063(2,6-Difluoro-3-(6-fluoro-3-methyl-5- (methyl(tetra...)
Affinity DataIC50: <100nMAssay Description:HSD17b13 enzyme was diluted in 1× assay buffer to the desired enzyme concentration based on the specific activity of the enzyme lot. 20 uL of diluted...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target17-beta-hydroxysteroid dehydrogenase 13(Human)
Fl2022-001

US Patent
LigandPNGBDBM649064(2,6-Difluoro-3-(6-fluoro-3-methyl-5-(7-oxa-4- azas...)
Affinity DataIC50: <100nMAssay Description:HSD17b13 enzyme was diluted in 1× assay buffer to the desired enzyme concentration based on the specific activity of the enzyme lot. 20 uL of diluted...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target17-beta-hydroxysteroid dehydrogenase 13(Human)
Fl2022-001

US Patent
LigandPNGBDBM649065(2,6-Difluoro-3-(6-fluoro-3-methyl-5- (methyl(tetra...)
Affinity DataIC50: <100nMAssay Description:HSD17b13 enzyme was diluted in 1× assay buffer to the desired enzyme concentration based on the specific activity of the enzyme lot. 20 uL of diluted...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target17-beta-hydroxysteroid dehydrogenase 13(Human)
Fl2022-001

US Patent
LigandPNGBDBM649066(2,6-Difluoro-3-(3-methyl-5-(methyl(tetrahydro- 2H-...)
Affinity DataIC50: <100nMAssay Description:HSD17b13 enzyme was diluted in 1× assay buffer to the desired enzyme concentration based on the specific activity of the enzyme lot. 20 uL of diluted...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target17-beta-hydroxysteroid dehydrogenase 13(Human)
Fl2022-001

US Patent
LigandPNGBDBM649067(2,6-Difluoro-3-(5-(methyl(tetrahydro-2H-pyran- 4-y...)
Affinity DataIC50: <100nMAssay Description:HSD17b13 enzyme was diluted in 1× assay buffer to the desired enzyme concentration based on the specific activity of the enzyme lot. 20 uL of diluted...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target17-beta-hydroxysteroid dehydrogenase 13(Human)
Fl2022-001

US Patent
LigandPNGBDBM649074(2,6-Difluoro-3-(5-(4-methoxypiperidin-1-yl)-3- met...)
Affinity DataIC50: <100nMAssay Description:HSD17b13 enzyme was diluted in 1× assay buffer to the desired enzyme concentration based on the specific activity of the enzyme lot. 20 uL of diluted...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target17-beta-hydroxysteroid dehydrogenase 13(Human)
Fl2022-001

US Patent
LigandPNGBDBM649075(2,6-Difluoro-3-(3-methyl-5-(methyl(tetrahydro- 2H-...)
Affinity DataIC50: <100nMAssay Description:HSD17b13 enzyme was diluted in 1× assay buffer to the desired enzyme concentration based on the specific activity of the enzyme lot. 20 uL of diluted...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target17-beta-hydroxysteroid dehydrogenase 13(Human)
Fl2022-001

US Patent
LigandPNGBDBM649076(2,6-Difluoro-3-(3-methyl-5-(2,2,6,6- tetramethylmo...)
Affinity DataIC50: <100nMAssay Description:HSD17b13 enzyme was diluted in 1× assay buffer to the desired enzyme concentration based on the specific activity of the enzyme lot. 20 uL of diluted...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target17-beta-hydroxysteroid dehydrogenase 13(Human)
Fl2022-001

US Patent
LigandPNGBDBM649078(2,6-Difluoro-3-(3-methyl-5-(4-oxa-7- azaspiro[2.5]...)
Affinity DataIC50: <100nMAssay Description:HSD17b13 enzyme was diluted in 1× assay buffer to the desired enzyme concentration based on the specific activity of the enzyme lot. 20 uL of diluted...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target17-beta-hydroxysteroid dehydrogenase 13(Human)
Fl2022-001

US Patent
LigandPNGBDBM649079(2,6-Difluoro-3-(3-methyl-5-(5-oxa-8- azaspiro[3.5]...)
Affinity DataIC50: <100nMAssay Description:HSD17b13 enzyme was diluted in 1× assay buffer to the desired enzyme concentration based on the specific activity of the enzyme lot. 20 uL of diluted...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
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