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Found 1387 with Last Name = 'lograsso' and Initial = 'p'
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM14028((S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of ROCK2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50614318(CHEMBL5278707)
Affinity DataKi:  2.40nMAssay Description:Inhibition of ROCK2 (unknown origin) using S6-peptide as substrate in presence of [33P]-ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))TBA
LigandPNGBDBM108025(US8604218, 2.039)
Affinity DataKi:  5nMAssay Description:Inhibition of ROCK1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50614319(CHEMBL5273210)
Affinity DataKi:  6.5nMAssay Description:Inhibition of ROCK2 (unknown origin) using S6-peptide as substrate in presence of [33P]-ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50161159(CHEMBL3793353)
Affinity DataKi:  10nMAssay Description:Inhibition of ROCK2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM108025(US8604218, 2.039)
Affinity DataKi:  14nMAssay Description:Inhibition of ROCK2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM217082(US9302989, 377)
Affinity DataKi:  20nMAssay Description:Inhibition of ROCK2 (unknown origin) using S6-peptide as substrate in presence of [33P]-ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50417857(CHEMBL1667969)
Affinity DataKi:  36nMAssay Description:Inhibition of human recombinant ROCK2 assessed as inhibition constant by microfluidic mobility shift methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM14029((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Affinity DataKi:  140nMAssay Description:Inhibition of ROCK2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM14027(5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4...)
Affinity DataKi:  330nMAssay Description:Inhibition of ROCK2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM16015(CHEMBL252967 | N-cyclopropyl-4-[4-(3,4-dichlorophe...)
Affinity DataIC50:  0.0780nMpH: 7.0 T: 2°CAssay Description:HTRF relies on fluorescence resonance energy transfer (FRET) between the donor, a europium cryptate (EuK), and the acceptor, the light harvesting pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50311713(CHEMBL1080279 | N-(2-(dimethylamino)ethyl)-N-(3-me...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86635(JNK-IN-10)
Affinity DataIC50:  0.5nMAssay Description:The binding results were confirmed by measuring IC50 for the inhibition of JNK kinase activity by using Z'-LYTE assay format.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86636(JNK-IN-11)
Affinity DataIC50:  0.5nMAssay Description:The binding results were confirmed by measuring IC50 for the inhibition of JNK kinase activity by using Z'-LYTE assay format.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86636(JNK-IN-11)
Affinity DataIC50:  0.5nMAssay Description:The binding results were confirmed by measuring IC50 for the inhibition of JNK kinase activity by using Z'-LYTE assay format.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86634(JNK-IN-9)
Affinity DataIC50:  0.5nMAssay Description:The binding results were confirmed by measuring IC50 for the inhibition of JNK kinase activity by using Z'-LYTE assay format.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86632(JNK-IN-7)
Affinity DataIC50:  0.75nMAssay Description:The binding results were confirmed by measuring IC50 for the inhibition of JNK kinase activity by using Z'-LYTE assay format.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50311728(3-(6-(1H-pyrazol-4-yl)benzo[d]thiazol-2-yl)-N-(3-(...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86630(JNK-IN-5)
Affinity DataIC50:  0.960nMAssay Description:The binding results were confirmed by measuring IC50 for the inhibition of JNK kinase activity by using Z'-LYTE assay format.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50:  0.980nMAssay Description:The binding results were confirmed by measuring IC50 for the inhibition of JNK kinase activity by using Z'-LYTE assay format.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50431137(CHEMBL2332060)
Affinity DataIC50:  1nMAssay Description:Inhibition of ROCK2 (unknown origin) after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50089582(CHEMBL3578250 | US9914740, I-1)
Affinity DataIC50: <1nMAssay Description:Inhibition of ROCK2 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate in presence of ATP by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50431134(CHEMBL2332068)
Affinity DataIC50:  1nMAssay Description:Inhibition of ROCK2 (unknown origin) after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50431135(CHEMBL2332065)
Affinity DataIC50:  1nMAssay Description:Inhibition of ROCK2 (unknown origin) after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50431144(CHEMBL2332099)
Affinity DataIC50:  1nMAssay Description:Inhibition of ROCK2 (unknown origin) after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50431145(CHEMBL2332098)
Affinity DataIC50:  1nMAssay Description:Inhibition of ROCK2 (unknown origin) after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50431138(CHEMBL2332097)
Affinity DataIC50:  1nMAssay Description:Inhibition of ROCK2 (unknown origin) after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50431143(CHEMBL2332057)
Affinity DataIC50:  1nMAssay Description:Inhibition of ROCK2 (unknown origin) after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))TBA
LigandPNGBDBM251935(US9458110, 7)
Affinity DataIC50:  1nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50:  1nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPurchaseMCE
In DepthDetails PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50614301(CHEMBL5270382)
Affinity DataIC50:  1nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50614300(CHEMBL5274003)
Affinity DataIC50:  1nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM252001(US9458110, 1)
Affinity DataIC50:  1nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM251935(US9458110, 7)
Affinity DataIC50: <1nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50338718(2-(6-fluorochroman-3-yl)-8-methoxy-6-(1H-pyrazol-4...)
Affinity DataIC50:  1nMAssay Description:Inhibition of ROCK2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50026330(CHEMBL1684210)
Affinity DataIC50: <1nMAssay Description:Inhibition of ROCK2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50026332(CHEMBL1684209)
Affinity DataIC50: <1nMAssay Description:Inhibition of ROCK2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50338703(CHEMBL1684208 | N-cyclopropyl-3-(4-oxo-6-(1H-pyraz...)
Affinity DataIC50:  1nMAssay Description:Inhibition of ROCK2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50026328(CHEMBL1684207)
Affinity DataIC50: <1nMAssay Description:Inhibition of ROCK2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50338722(8-methoxy-2-((3-methoxyphenoxy)methyl)-6-(1H-pyraz...)
Affinity DataIC50:  1nMAssay Description:Inhibition of ROCK2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50026327(CHEMBL1684206)
Affinity DataIC50: <1nMAssay Description:Inhibition of ROCK2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50026346(CHEMBL1684201)
Affinity DataIC50: <1nMAssay Description:Inhibition of ROCK2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50324585(CHEMBL1215022 | N-(4-(1H-Pyrazol-4-yl)phenyl)-2-am...)
Affinity DataIC50:  1nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50324574((R)-6-Methoxy-N-(2-((1-methylpiperidin-4-yl)methox...)
Affinity DataIC50: <1nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50246461(4-(7-fluoro-2-(6-methoxy-3,4-dihydro-2H-chromen-3-...)
Affinity DataIC50: <1nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50246460(3-(6-(2-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2...)
Affinity DataIC50: <1nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50246459(3-(6-(2-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2...)
Affinity DataIC50: <1nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50358712(CHEMBL1922127)
Affinity DataIC50:  1nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50358713(CHEMBL1922128)
Affinity DataIC50:  1nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50358486(CHEMBL1923173)
Affinity DataIC50: <1nMAssay Description:Inhibition of human 6-His-tagged ROCK2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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