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Found 68 with Last Name = 'luxen' and Initial = 'a'
Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Escherichia coli)
Victoria University Of Wellington

Curated by ChEMBL
LigandPNGBDBM22113((3R,4S)-1-({4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-y...)
Affinity DataKi:  0.00200nMAssay Description:Inhibition of recombinant Escherichia coli MTAN expressed in Escherichia coli BL-21 DE3 using methylthioadenosine as substrate assessed as inhibition...More data for this Ligand-Target Pair
Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Escherichia coli)
Victoria University Of Wellington

Curated by ChEMBL
LigandPNGBDBM22113((3R,4S)-1-({4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-y...)
Affinity DataKi:  0.0480nMAssay Description:Inhibition of recombinant Escherichia coli MTAN expressed in Escherichia coli BL-21 DE3 using methylthioadenosine as substrate by xanthine oxidase co...More data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Victoria University Of Wellington

Curated by ChEMBL
LigandPNGBDBM50247151(7-(((3R,4S)-3-hydroxy-4-(methylthiomethyl)pyrrolid...)
Affinity DataKi:  0.0700nMAssay Description:Inhibition of recombinant human PNP using inosine as substrate assessed as inhibition constant for slow onset inhibition of enzyme-inhibitor complex ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Victoria University Of Wellington

Curated by ChEMBL
LigandPNGBDBM22113((3R,4S)-1-({4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-y...)
Affinity DataKi:  0.0780nMAssay Description:Inhibition of human MTAP using methylthioadenosine as substrate assessed as inhibition constant for slow onset inhibition of enzyme-inhibitor complex...More data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Victoria University Of Wellington

Curated by ChEMBL
LigandPNGBDBM50247151(7-(((3R,4S)-3-hydroxy-4-(methylthiomethyl)pyrrolid...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of recombinant human PNP using inosine as substrate by xanthine oxidase coupling enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Victoria University Of Wellington

Curated by ChEMBL
LigandPNGBDBM22113((3R,4S)-1-({4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-y...)
Affinity DataKi:  0.530nMAssay Description:Inhibition of human MTAP using methylthioadenosine as substrate by xanthine oxidase coupling enzyme assayMore data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Plasmodium falciparum)
Victoria University Of Wellington

Curated by ChEMBL
LigandPNGBDBM50247151(7-(((3R,4S)-3-hydroxy-4-(methylthiomethyl)pyrrolid...)
Affinity DataKi:  0.900nMAssay Description:Inhibition of recombinant Plasmodium falciparum PNP using inosine as substrate assessed as inhibition constant for slow onset inhibition of enzyme-in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Escherichia coli)
Victoria University Of Wellington

Curated by ChEMBL
LigandPNGBDBM50116357(CHEMBL3604360)
Affinity DataKi:  4.5nMAssay Description:Inhibition of recombinant Escherichia coli MTAN expressed in Escherichia coli BL-21 DE3 using methylthioadenosine as substrate by xanthine oxidase co...More data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Plasmodium falciparum)
Victoria University Of Wellington

Curated by ChEMBL
LigandPNGBDBM50247151(7-(((3R,4S)-3-hydroxy-4-(methylthiomethyl)pyrrolid...)
Affinity DataKi:  11nMAssay Description:Inhibition of recombinant Plasmodium falciparum PNP using inosine as substrate by xanthine oxidase coupling enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
TBA

Curated by ChEMBL
LigandPNGBDBM50337102((S)-1-(2-(Diphenylmethyl)benzamido)ethaneboronate ...)
Affinity DataKi:  63nMAssay Description:Inhibition of Actinomadura R39 PBP after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Victoria University Of Wellington

Curated by ChEMBL
LigandPNGBDBM50116358(CHEMBL3604359)
Affinity DataKi:  84nMAssay Description:Inhibition of recombinant human PNP using inosine as substrate assessed as inhibition constant for slow onset inhibition of enzyme-inhibitor complex ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Plasmodium falciparum)
Victoria University Of Wellington

Curated by ChEMBL
LigandPNGBDBM50116358(CHEMBL3604359)
Affinity DataKi:  93nMAssay Description:Inhibition of recombinant Plasmodium falciparum PNP using inosine as substrate assessed as inhibition constant for slow onset inhibition of enzyme-in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
TBA

Curated by ChEMBL
LigandPNGBDBM50337101((S)-1-(2-(Naphthalen-2-ylcarbonyl)benzamido)ethane...)
Affinity DataKi:  105nMAssay Description:Inhibition of Actinomadura R39 PBP after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Victoria University Of Wellington

Curated by ChEMBL
LigandPNGBDBM50116358(CHEMBL3604359)
Affinity DataKi:  110nMAssay Description:Inhibition of recombinant human PNP using inosine as substrate by xanthine oxidase coupling enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Plasmodium falciparum)
Victoria University Of Wellington

Curated by ChEMBL
LigandPNGBDBM50116358(CHEMBL3604359)
Affinity DataKi:  298nMAssay Description:Inhibition of recombinant Plasmodium falciparum PNP using inosine as substrate by xanthine oxidase coupling enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
TBA

Curated by ChEMBL
LigandPNGBDBM50385268(CHEMBL2035292)
Affinity DataKi:  360nMAssay Description:Binding affinity to Actinomadura sp. R39 PBPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Victoria University Of Wellington

Curated by ChEMBL
LigandPNGBDBM50116357(CHEMBL3604360)
Affinity DataKi:  750nMAssay Description:Inhibition of human MTAP using methylthioadenosine as substrate by xanthine oxidase coupling enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
TBA

Curated by ChEMBL
LigandPNGBDBM50385267(CHEMBL2035284)
Affinity DataKi:  1.50E+3nMAssay Description:Binding affinity to Actinomadura sp. R39 PBPMore data for this Ligand-Target Pair
TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
TBA

Curated by ChEMBL
LigandPNGBDBM50385263(CHEMBL2035289)
Affinity DataKi:  4.20E+4nMAssay Description:Binding affinity to Actinomadura sp. R39 PBPMore data for this Ligand-Target Pair
TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
TBA

Curated by ChEMBL
LigandPNGBDBM39809(Acylglycineboronic acid, 6)
Affinity DataKi:  1.25E+5nMAssay Description:Binding affinity to Actinomadura sp. R39 PBPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Victoria University Of Wellington

Curated by ChEMBL
LigandPNGBDBM50281297(CHEMBL4170114)
Affinity DataIC50:  8nMAssay Description:Inhibition of G9a (unknown origin) using biotinylated histone monomethyl-H3K9 peptide by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
TBA

Curated by ChEMBL
LigandPNGBDBM50337101((S)-1-(2-(Naphthalen-2-ylcarbonyl)benzamido)ethane...)
Affinity DataIC50:  80nMAssay Description:Inhibition of Actinomadura R39 PBP after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
TBA

Curated by ChEMBL
LigandPNGBDBM50337094((S)-1-(2-Fluoro-6-phenylbenzamido)ethaneboronic ac...)
Affinity DataIC50:  270nMAssay Description:Inhibition of Actinomadura R39 PBP after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
TBA

Curated by ChEMBL
LigandPNGBDBM50337100((S)-1-(2-[(Phenylsulfonyl)amino]benzamido)ethanebo...)
Affinity DataIC50:  370nMAssay Description:Inhibition of Actinomadura R39 PBP after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Victoria University Of Wellington

Curated by ChEMBL
LigandPNGBDBM50281297(CHEMBL4170114)
Affinity DataIC50:  382nMAssay Description:Inhibition of DNMT1 (unknown origin) using biotinylated histone monomethyl-H3K9 peptide by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
TBA

Curated by ChEMBL
LigandPNGBDBM50337095((S)-1-(2,6-Difluorobenzamido)ethaneboronic acid | ...)
Affinity DataIC50:  500nMAssay Description:Inhibition of Actinomadura R39 PBP after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
TBA

Curated by ChEMBL
LigandPNGBDBM50385268(CHEMBL2035292)
Affinity DataIC50:  600nMAssay Description:Inhibition of Actinomadura sp. R39 PBP using S2d as substrate incubated for 60 mins prior to substrate addition by DTNB-based spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
TBA

Curated by ChEMBL
LigandPNGBDBM50385267(CHEMBL2035284)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of Actinomadura sp. R39 PBP using S2d as substrate incubated for 60 mins prior to substrate addition by DTNB-based spectrophotometryMore data for this Ligand-Target Pair
TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
TBA

Curated by ChEMBL
LigandPNGBDBM50337093((S)-1-(2-Phenylbenzamido)ethaneboronic acid | CHEM...)
Affinity DataIC50:  1.31E+3nMAssay Description:Inhibition of Actinomadura R39 PBP after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
TBA

Curated by ChEMBL
LigandPNGBDBM50337092((S)-1-(2-Benzylbenzamido)ethaneboronic acid | CHEM...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of Actinomadura R39 PBP after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
TBA

Curated by ChEMBL
LigandPNGBDBM50337091((S)-1-(1-Benzothiophene-5-carboxamido)ethaneboroni...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of Actinomadura R39 PBP after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
TBA

Curated by ChEMBL
LigandPNGBDBM50337098((R)-1-(2,6-Difluorobenzamido)ethaneboronic acid | ...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of Actinomadura R39 PBP after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
TBA

Curated by ChEMBL
LigandPNGBDBM50337096((S)-1-(2,6-Dichlorobenzamido)ethaneboronic acid | ...)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of Actinomadura R39 PBP after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
TBA

Curated by ChEMBL
LigandPNGBDBM50337099((R)-1-(2-Benzylbenzamido)ethaneboronic acid | CHEM...)
Affinity DataIC50:  7.20E+3nMAssay Description:Inhibition of Actinomadura R39 PBP after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPenicillin-binding protein 2x(Streptococcus pneumoniae)
Universit£

Curated by ChEMBL
LigandPNGBDBM50324696(CHEMBL1221990 | Phenoxyacetyl lactivicin)
Affinity DataIC50:  7.90E+3nMAssay Description:Inhibition of penicillin-resistant Streptococcus pneumoniae 5204 PBP2x after 60 mins by SDS-PAGEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
TBA

Curated by ChEMBL
LigandPNGBDBM50337090((S)-1-(Naphthalene-2-carboxamido)ethaneboronic aci...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of Actinomadura R39 PBP after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
TBA

Curated by ChEMBL
LigandPNGBDBM50385266(CHEMBL2035295)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of Actinomadura sp. R39 PBP using S2d as substrate incubated for 60 mins prior to substrate addition by DTNB-based spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50411202(CHEMBL216129)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of MM6 cell adhesion to recombinant E-selectin by flow chamber assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
TBA

Curated by ChEMBL
LigandPNGBDBM50300661(3-borono-5-(2-methoxybenzamido)benzoic acid | CHEM...)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibition of Actinomadura sp. R39 penicillin-binding protein preincubated for 60 mins before addition of substrate mixture of (R)-[2-(benzoylamino)p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
TBA

Curated by ChEMBL
LigandPNGBDBM50300664(3-borono-5-(2-phenoxyacetamido)benzoic acid | CHEM...)
Affinity DataIC50:  2.80E+4nMAssay Description:Inhibition of Actinomadura sp. R39 penicillin-binding protein preincubated for 60 mins before addition of substrate mixture of (R)-[2-(benzoylamino)p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50411201(CHEMBL217490)
Affinity DataIC50:  2.80E+4nMAssay Description:Inhibition of MM6 cell adhesion to recombinant E-selectin by flow chamber assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
TBA

Curated by ChEMBL
LigandPNGBDBM50300662(3-borono-5-(thiophene-2-carboxamido)benzoic acid |...)
Affinity DataIC50:  3.20E+4nMAssay Description:Inhibition of Actinomadura sp. R39 penicillin-binding protein preincubated for 60 mins before addition of substrate mixture of (R)-[2-(benzoylamino)p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
TBA

Curated by ChEMBL
LigandPNGBDBM50300660(3-benzamido-5-boronobenzoic acid | CHEMBL575719)
Affinity DataIC50:  3.40E+4nMAssay Description:Inhibition of Actinomadura sp. R39 penicillin-binding protein preincubated for 60 mins before addition of substrate mixture of (R)-[2-(benzoylamino)p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
TBA

Curated by ChEMBL
LigandPNGBDBM50385262(CHEMBL2035285)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of Actinomadura sp. R39 PBP using S2d as substrate incubated for 60 mins prior to substrate addition by DTNB-based spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50411200(CHEMBL385486)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of MM6 cell adhesion to recombinant E-selectin by flow chamber assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
TBA

Curated by ChEMBL
LigandPNGBDBM50337097((S)-1-(2-(Propan-2-yl)benzamido)ethaneboronic acid...)
Affinity DataIC50:  5.90E+4nMAssay Description:Inhibition of Actinomadura R39 PBP after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPenicillin-binding protein 2x(Streptococcus pneumoniae)
Universit£

Curated by ChEMBL
LigandPNGBDBM50300689(6-chloro-2-(3-(4-chloro-2-methylphenyl)ureido)-3-(...)
Affinity DataIC50:  7.10E+4nMAssay Description:Inhibition of penicillin-resistant Streptococcus pneumoniae 5204 PBP2X preincubated for 4 hrs before addition of substrate (R)-[2-(benzoylamino)propi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPenicillin-binding protein 2x(Streptococcus pneumoniae)
Universit£

Curated by ChEMBL
LigandPNGBDBM50300688(6-chloro-3-(3,4-dichlorophenoxy)-2-(3-(3-(trifluor...)
Affinity DataIC50:  7.20E+4nMAssay Description:Inhibition of penicillin-resistant Streptococcus pneumoniae 5204 PBP2X preincubated for 4 hrs before addition of substrate (R)-[2-(benzoylamino)propi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
TBA

Curated by ChEMBL
LigandPNGBDBM50300663(3-borono-5-(2-(thiophen-2-yl)acetamido)benzoic aci...)
Affinity DataIC50:  7.80E+4nMAssay Description:Inhibition of Actinomadura sp. R39 penicillin-binding protein preincubated for 60 mins before addition of substrate mixture of (R)-[2-(benzoylamino)p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
TBA

Curated by ChEMBL
LigandPNGBDBM50385263(CHEMBL2035289)
Affinity DataIC50:  8.50E+4nMAssay Description:Inhibition of Actinomadura sp. R39 PBP using S2d as substrate incubated for 60 mins prior to substrate addition by DTNB-based spectrophotometryMore data for this Ligand-Target Pair
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