Affinity DataKi: 1.40nMAssay Description:Inhibition of human full-length recombinant ARTD1 assessed as incorporation of [32P]NAD+ by scintillation counting analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University
Curated by ChEMBL
Abo Akademi University
Curated by ChEMBL
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Abo Akademi University
Curated by ChEMBL
Abo Akademi University
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Inhibition of ARTD1 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Abo Akademi University
Curated by ChEMBL
Abo Akademi University
Curated by ChEMBL
Affinity DataIC50: 52nMAssay Description:Inhibition of human 6XHis-tagged TNKS1 SAM-ART domain (1030 to 1317 amino acid residues) by fluorescence assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University
Curated by ChEMBL
Abo Akademi University
Curated by ChEMBL
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Abo Akademi University
Curated by ChEMBL
Abo Akademi University
Curated by ChEMBL
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University
Curated by ChEMBL
Abo Akademi University
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of human 6XHis-tagged TNKS2 ART domain (946 to 1161 amino acid residues) expressed in Escherichia coli Rosetta2 (DE3) by fluorescence assa...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University
Curated by ChEMBL
Abo Akademi University
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of human 6XHis-tagged TNKS2 ART domain (946 to 1161 amino acid residues) expressed in Escherichia coli Rosetta2 (DE3) by fluorescence assa...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Abo Akademi University
Curated by ChEMBL
Abo Akademi University
Curated by ChEMBL
Affinity DataIC50: 230nMAssay Description:Inhibition of human 6XHis-tagged TNKS1 SAM-ART domain (1030 to 1317 amino acid residues) by fluorescence assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Abo Akademi University
Curated by ChEMBL
Abo Akademi University
Curated by ChEMBL
Affinity DataIC50: 280nMAssay Description:Inhibition of human 6XHis-tagged TNKS1 SAM-ART domain (1030 to 1317 amino acid residues) by fluorescence assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Abo Akademi University
Curated by ChEMBL
Abo Akademi University
Curated by ChEMBL
Affinity DataIC50: 280nMAssay Description:Inhibition of human 6XHis-tagged TNKS1 SAM-ART domain (1030 to 1317 amino acid residues) by fluorescence assayMore data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP15 [460-656,Y598L](Homo sapiens (Human))
University of Oulu
University of Oulu
Affinity DataIC50: 295nMAssay Description:This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of calf thymus ARTD1 assessed as incorporation of [Ade-U-14C]-NAD+ after 10 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University
Curated by ChEMBL
Abo Akademi University
Curated by ChEMBL
Affinity DataIC50: 310nMAssay Description:Inhibition of human 6XHis-tagged TNKS2 ART domain (946 to 1161 amino acid residues) expressed in Escherichia coli Rosetta2 (DE3) by fluorescence assa...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Abo Akademi University
Curated by ChEMBL
Abo Akademi University
Curated by ChEMBL
Affinity DataIC50: 310nMAssay Description:Inhibition of human 6XHis-tagged TNKS1 SAM-ART domain (1030 to 1317 amino acid residues) by fluorescence assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Abo Akademi University
Curated by ChEMBL
Abo Akademi University
Curated by ChEMBL
Affinity DataIC50: 320nMAssay Description:Inhibition of human 6XHis-tagged TNKS1 SAM-ART domain (1030 to 1317 amino acid residues) by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 329nMAssay Description:This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University
Curated by ChEMBL
Abo Akademi University
Curated by ChEMBL
Affinity DataIC50: 450nMAssay Description:Inhibition of human 6XHis-tagged TNKS2 ART domain (946 to 1161 amino acid residues) expressed in Escherichia coli Rosetta2 (DE3) by fluorescence assa...More data for this Ligand-Target Pair
Affinity DataIC50: 450nMAssay Description:Inhibition of bovine ARTD1 assessed as incorporation of [adenine-2,8-3H]NAD after 1 hr by liquid scintillation spectrometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 479nMAssay Description:Inhibition of human full length ARTD2 using NAD+ as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 479nMAssay Description:Inhibition of human full length ARTD2 using NAD+ as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Abo Akademi University
Curated by ChEMBL
Abo Akademi University
Curated by ChEMBL
Affinity DataIC50: 560nMAssay Description:Inhibition of human 6XHis-tagged TNKS1 SAM-ART domain (1030 to 1317 amino acid residues) by fluorescence assayMore data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP10 [809-1017,R931A](Homo sapiens (Human))
University of Oulu
University of Oulu
Affinity DataIC50: 597nMAssay Description:This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University
Curated by ChEMBL
Abo Akademi University
Curated by ChEMBL
Affinity DataIC50: 620nMAssay Description:Inhibition of human 6XHis-tagged TNKS2 ART domain (946 to 1161 amino acid residues) expressed in Escherichia coli Rosetta2 (DE3) by fluorescence assa...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Abo Akademi University
Curated by ChEMBL
Abo Akademi University
Curated by ChEMBL
Affinity DataIC50: 630nMAssay Description:Inhibition of human 6XHis-tagged TNKS1 SAM-ART domain (1030 to 1317 amino acid residues) by fluorescence assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University
Curated by ChEMBL
Abo Akademi University
Curated by ChEMBL
Affinity DataIC50: 870nMAssay Description:Inhibition of human 6XHis-tagged TNKS2 ART domain (946 to 1161 amino acid residues) expressed in Escherichia coli Rosetta2 (DE3) by fluorescence assa...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University
Curated by ChEMBL
Abo Akademi University
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human 6XHis-tagged TNKS2 ART domain (946 to 1161 amino acid residues) expressed in Escherichia coli Rosetta2 (DE3) by fluorescence assa...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University
Curated by ChEMBL
Abo Akademi University
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human 6XHis-tagged TNKS2 ART domain (946 to 1161 amino acid residues) expressed in Escherichia coli Rosetta2 (DE3) by fluorescence assa...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University
Curated by ChEMBL
Abo Akademi University
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human 6XHis-tagged TNKS2 ART domain (946 to 1161 amino acid residues) expressed in Escherichia coli Rosetta2 (DE3) by fluorescence assa...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human recombinant ARTD1 by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human recombinant ARTD1 by fluorescence assayMore data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP14 [1535-1801,Y1660L](Homo sapiens (Human))
University of Oulu
University of Oulu
Affinity DataIC50: 1.63E+3nMAssay Description:This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP10 [809-1017,S927A](Homo sapiens (Human))
University of Oulu
University of Oulu
Affinity DataIC50: 2.25E+3nMAssay Description:This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Abo Akademi University
Curated by ChEMBL
Abo Akademi University
Curated by ChEMBL
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of human 6XHis-tagged TNKS1 SAM-ART domain (1030 to 1317 amino acid residues) by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of human recombinant ARTD1 by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of human full length ARTD1 using NAD+ as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.69E+3nMAssay Description:Inhibition of human full length ARTD1 using NAD+ as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University
Curated by ChEMBL
Abo Akademi University
Curated by ChEMBL
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of human 6XHis-tagged TNKS2 ART domain (946 to 1161 amino acid residues) expressed in Escherichia coli Rosetta2 (DE3) by fluorescence assa...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Abo Akademi University
Curated by ChEMBL
Abo Akademi University
Curated by ChEMBL
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of human 6XHis-tagged TNKS1 SAM-ART domain (1030 to 1317 amino acid residues) by fluorescence assayMore data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP10 [809-1017,L926Y](Homo sapiens (Human))
University of Oulu
University of Oulu
Affinity DataIC50: 3.84E+3nMAssay Description:This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.17E+3nMAssay Description:This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of human recombinant ARTD1 by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of human full length ARTD1 using NAD+ as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.62E+3nMAssay Description:Inhibition of human full length ARTD1 using NAD+ as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.08E+3nMAssay Description:Inhibition of human full length ARTD1 using NAD+ as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of human full length ARTD1 using NAD+ as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of human recombinant ARTD1 by fluorescence assayMore data for this Ligand-Target Pair