Compile Data Set for Download or QSAR
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Found 757 with Last Name = 'parker' and Initial = 'ca'
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50335260(CHEMBL1651226 | N,N-dihexyl-2-(1-methyl-2-phenyl-1...)
Affinity DataKi:  0.299nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50335259(CHEMBL1651225 | N,N-dibutyl-2-(1-methyl-2-phenyl-1...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM22038(2-[2-(4-fluorophenyl)-1H-indol-3-yl]-N,N-dihexyl-2...)
Affinity DataKi:  0.370nMAssay Description:Displacement of [11C]PBR28 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50060095(2-[6,8-Dichloro-2-(4-chloro-phenyl)-imidazo[1,2-a]...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50335268(2-(2-(4-fluorophenyl)-1-methyl-1H-indol-3-yl)-N,N-...)
Affinity DataKi:  1.07nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50143220(CHEMBL294625 | N,N-Dihexyl-2-oxo-2-(2-phenyl-1H-in...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [11C]PBR28 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50335270(2-(1-methyl-2-(4-nitrophenyl)-1H-indol-3-yl)-2-oxo...)
Affinity DataKi:  1.57nMAssay Description:Displacement of [11C]PK11195 from high affinity binding site of TSPO in human brain membrane homogenate by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50335257(CHEMBL1651223 | N-benzyl-2-(2-(4-fluorophenyl)-1H-...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50335270(2-(1-methyl-2-(4-nitrophenyl)-1H-indol-3-yl)-2-oxo...)
Affinity DataKi:  1.82nMAssay Description:Displacement of [11C]PK11195 from mixed affinity binding site of TSPO in human brain membrane homogenate by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50335262(CHEMBL1651228 | N-benzyl-N-ethyl-2-(1-methyl-2-phe...)
Affinity DataKi:  2.92nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50143244(2-[2-(4-Fluoro-phenyl)-1H-indol-3-yl]-2-oxo-N,N-di...)
Affinity DataKi:  4.28nMAssay Description:Displacement of [11C]PBR28 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50335270(2-(1-methyl-2-(4-nitrophenyl)-1H-indol-3-yl)-2-oxo...)
Affinity DataKi:  5.70nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50335269(CHEMBL1651235 | N-benzyl-2-(2-(4-fluorophenyl)-1-m...)
Affinity DataKi:  6.77nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50143236(CHEMBL431938 | N,N-Dibutyl-2-oxo-2-(2-phenyl-1H-in...)
Affinity DataKi:  7.5nMAssay Description:Displacement of [11C]PBR28 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM22032(1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...)
Affinity DataKi:  9.30nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
TargetTranslocator protein(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50335270(2-(1-methyl-2-(4-nitrophenyl)-1H-indol-3-yl)-2-oxo...)
Affinity DataKi:  9.53nMAssay Description:Displacement of [11C]PK11195 from low affinity binding site of TSPO in human brain membrane homogenate by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50335256(CHEMBL1651222 | N-benzyl-N-methyl-2-oxo-2-(2-pheny...)
Affinity DataKi:  12nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50143223(2-Oxo-2-(2-phenyl-1H-indol-3-yl)-N,N-dipropyl-acet...)
Affinity DataKi:  12.2nMAssay Description:Displacement of [11C]PBR28 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50335258(2-(1-methyl-2-phenyl-1H-indol-3-yl)-2-oxo-N,N-dipr...)
Affinity DataKi:  19.5nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50335267(2-(2-(4-fluorophenyl)-1-methyl-1H-indol-3-yl)-2-ox...)
Affinity DataKi:  19.8nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50335265(CHEMBL1651231 | N-benzyl-N-methyl-2-(1-methyl-2-ph...)
Affinity DataKi:  20.9nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM22040(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)
Affinity DataKi:  23nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50335266(2-(5-fluoro-1-methyl-2-phenyl-1H-indol-3-yl)-2-oxo...)
Affinity DataKi:  23.7nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50335264(CHEMBL1651230 | N-methyl-2-(1-methyl-2-phenyl-1H-i...)
Affinity DataKi:  38.2nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50335261(CHEMBL1651227 | N-butyl-N-ethyl-2-(1-methyl-2-phen...)
Affinity DataKi:  60.2nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50335263(CHEMBL1651229 | N-butyl-N-methyl-2-(1-methyl-2-phe...)
Affinity DataKi:  190nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50152127(CHEMBL3780962)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50152144(CHEMBL3781661)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM488485(US10954243, Example 16)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human SHP2 assessed as downregulation of PERK level in human KYSE520 cells incubated for 2 hrs by Alpha screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50152130(CHEMBL3780613)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50152129(CHEMBL3780596)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of Texas

Curated by ChEMBL
LigandPNGBDBM506627(US11046649, Ex. 5)
Affinity DataIC50:  0.520nMAssay Description:Inhibition of IDO1 in human HeLa cells using tryptophan as substrate incubated for 24 hrs by RFMS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of Texas

Curated by ChEMBL
LigandPNGBDBM50578624(CHEMBL4856710)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of IDO1 in human HeLa cells using tryptophan as substrate incubated for 24 hrs by RFMS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50152145(CHEMBL3780032)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of Texas

Curated by ChEMBL
LigandPNGBDBM50578623(CHEMBL4858888)
Affinity DataIC50:  0.690nMAssay Description:Inhibition of IDO1 in human HeLa cells using tryptophan as substrate incubated for 24 hrs by RFMS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50152125(CHEMBL3781316)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of recombinant human MTH1 assessed as hydrolysis of dGTP to dGMP and pyrophosphate after 15 mins by malachite green-based microplate reade...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50560806(CHEMBL4758092)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of Texas

Curated by ChEMBL
LigandPNGBDBM50578677(CHEMBL4849690)
Affinity DataIC50:  0.920nMAssay Description:Inhibition of IDO1 in human HeLa cells using tryptophan as substrate incubated for 24 hrs by RFMS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50460035(CHEMBL4227505)
Affinity DataIC50:  1nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of Texas

Curated by ChEMBL
LigandPNGBDBM50578635(CHEMBL4875089)
Affinity DataIC50:  1nMAssay Description:Inhibition of IDO1 in human HeLa cells using tryptophan as substrate incubated for 24 hrs by RFMS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Mus musculus)
University Of Texas

Curated by ChEMBL
LigandPNGBDBM50578623(CHEMBL4858888)
Affinity DataIC50:  1nMAssay Description:Inhibition of IDO1 in mouse Panc02 cells assessed as reduction in NFK level incubated for 48 hrs by RFMS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM488485(US10954243, Example 16)
Affinity DataIC50:  1nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50560807(CHEMBL4751287)
Affinity DataIC50:  1nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50560804(CHEMBL4763875)
Affinity DataIC50:  1nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50560786(CHEMBL4798876)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50560798(CHEMBL4795462)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50560801(CHEMBL4798601)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50560791(CHEMBL4740157)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of Texas

Curated by ChEMBL
LigandPNGBDBM50578639(CHEMBL4868112)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of IDO1 in human HeLa cells using tryptophan as substrate incubated for 24 hrs by RFMS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50560788(CHEMBL4759047)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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