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Found 303 with Last Name = 'patel' and Initial = 'dv'
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM12657(1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2-(methylsul...)
Affinity DataKi:  0.150nMAssay Description:Binding affinity to human FXa assessed as inhibition constantMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50614408(CHEMBL5269594)
Affinity DataKi:  0.800nMAssay Description:Binding affinity to human FXa assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50096104(2-(3-Aminomethyl-phenyl)-5-trifluoromethyl-2H-pyra...)
Affinity DataKi:  0.910nMAssay Description:Binding affinity to FXa (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50614410(CHEMBL5286872)
Affinity DataKi:  1nMAssay Description:Binding affinity to human FXa assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50614403(CHEMBL5291366)
Affinity DataKi:  2nMAssay Description:Binding affinity to FXa (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPDB
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50614404(CHEMBL5266057)
Affinity DataKi:  2nMAssay Description:Binding affinity to FXa (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPDB
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50614409(CHEMBL5276446)
Affinity DataKi:  2nMAssay Description:Binding affinity to human FXa assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50614407(CHEMBL5276447)
Affinity DataKi:  25nMAssay Description:Binding affinity to FXa (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50614405(CHEMBL4283525)
Affinity DataKi:  146nMAssay Description:Binding affinity to FXa (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPDB
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50614406(CHEMBL4294106)
Affinity DataKi:  1.62E+3nMAssay Description:Binding affinity to FXa (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPDB
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50070256((R)-2-((S)-2-Hydroxy-3-mercapto-propyl)-nonanoic a...)
Affinity DataIC50:  0.140nMAssay Description:Inhibition of matrix metalloproteinase-9, gelatinase-BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50070257((R)-2-(3-Mercapto-2-oxo-propyl)-nonanoic acid ((S)...)
Affinity DataIC50:  0.140nMAssay Description:Inhibition of matrix metalloproteinase-9, gelatinase-BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50070228(2-(2-Mercapto-acetyl)-nonanoic acid ((S)-2,2-dimet...)
Affinity DataIC50:  0.300nMAssay Description:In vitro inhibitory activity against gelatinase-B(MMP-9).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048982((R)-2-({(R)-2-[(R)-2-((S)-2-Amino-3-mercapto-propi...)
Affinity DataIC50:  0.370nMAssay Description:In vitro inhibitory activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048970((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Affinity DataIC50:  0.460nMAssay Description:In vitro inhibitory activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048963((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Affinity DataIC50:  0.570nMAssay Description:In vitro inhibitory activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048972((R)-2-({(R)-2-[(R)-2-((S)-2-Amino-3-mercapto-propy...)
Affinity DataIC50:  0.600nMAssay Description:In vitro inhibitory activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048967((R)-2-({(R)-2-[(R)-2-((S)-2-Amino-3-mercapto-propy...)
Affinity DataIC50:  0.75nMAssay Description:In vitro inhibitory activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM25743(1-cycloheptyl-3-(1-acetylpiperidin-4-yl)urea | US8...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM50276625(1-Adamantan-1-yl-3-[3-(3-morpholin-4-yl-propoxy)-p...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of soluble epoxide hydrolase (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048964((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Affinity DataIC50:  0.920nMAssay Description:In vitro inhibitory activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048981((S)-2-({(R)-2-[(S)-2-((R)-3-Mercapto-2-methyl-prop...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibitory activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM50276673(1-(3-(3-morpholinopropoxy)phenyl)-3-(4-(trifluorom...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of soluble epoxide hydrolase (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048966((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Affinity DataIC50:  1.30nMAssay Description:In vitro inhibition of Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50070247(2-(2-Mercapto-acetyl)-nonanoic acid ((S)-2-cyclohe...)
Affinity DataIC50:  1.40nMAssay Description:In vitro inhibitory activity against gelatinase-B(MMP-9).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50070227(2-(2-Mercapto-acetyl)-nonanoic acid ((S)-3-methyl-...)
Affinity DataIC50:  1.40nMAssay Description:In vitro inhibitory activity against gelatinase-B(MMP-9).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048968((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Affinity DataIC50:  1.40nMAssay Description:In vitro inhibitory activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM50335965(1-(1-(isopropylsulfonyl)piperidin-4-yl)-3-(4-(trif...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM50335964(1-(1-nicotinoylpiperidin-4-yl)-3-(4-(trifluorometh...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048969((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Affinity DataIC50:  1.80nMAssay Description:In vitro inhibitory activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM50335966(1-Adamantan-1-yl-3-(1-methanesulfonyl-piperidin-4-...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
Affymax Research Institute

Curated by ChEMBL
LigandPNGBDBM50070250(2-(1-Hydroxy-2-mercapto-ethyl)-5-phenyl-pentanoic ...)
Affinity DataIC50: >2nMAssay Description:In vitro inhibitory activity against stromelysin-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM50276676(2-Adamantan-1-yl-N-[3-(3-morpholin-4-yl-propoxy)-p...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of soluble epoxide hydrolase (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048974((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Affinity DataIC50:  2.80nMAssay Description:In vitro inhibitory activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM50335967(1-(1-(isopropylsulfonyl)piperidin-4-yl)-3-(4-(trif...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Mus musculus (Mouse))
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM50191854(CHEMBL436774 | N-(1-acetyl-piperidin-4-yl)-N'-(ada...)
Affinity DataIC50:  3nMAssay Description:Inhibition of mouse soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM50335968(1-(1-(methylsulfonyl)piperidin-4-yl)-3-(4-(trifluo...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM50335966(1-Adamantan-1-yl-3-(1-methanesulfonyl-piperidin-4-...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of soluble epoxide hydrolase in HUVEC assessed inhibition of as conversion of 14, 15-EET to 14, 15-DHETMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM50276626(1-cyclohexyl-3-(3-(3-morpholinopropoxy)phenyl)urea...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of soluble epoxide hydrolase (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50070226(2-(2-Mercapto-acetyl)-nonanoic acid {(S)-2-cyclohe...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibitory activity against gelatinase-B(MMP-9).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048975((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Affinity DataIC50:  4.40nMAssay Description:In vitro inhibitory activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048963((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Affinity DataIC50:  4.80nMAssay Description:In vitro inhibition of Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50029588((2R,3S)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3...)
Affinity DataIC50:  5nMAssay Description:Evaluation of inhibitory activity of the compound against human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50070223(2-(2-Mercapto-acetyl)-nonanoic acid ((S)-3-methyl-...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibitory activity against gelatinase-B(MMP-9).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50070256((R)-2-((S)-2-Hydroxy-3-mercapto-propyl)-nonanoic a...)
Affinity DataIC50:  5nMAssay Description:Inhibition of matrix metalloproteinase-1, Collagenase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50063920((R)-N*1*-((S)-2,2-Dimethyl-1-methylcarbamoyl-propy...)
Affinity DataIC50:  5nMAssay Description:Inhibition of matrix metalloproteinase-1, Collagenase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM50335969(1-(1-acetylpiperidin-4-yl)-3-(4,4-dimethylcyclohex...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50070239(2-(2-Mercapto-acetyl)-nonanoic acid [(S)-3-methyl-...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibitory activity against gelatinase-B(MMP-9).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50070229(2-(2-Mercapto-acetyl)-4-methyl-pentanoic acid ((S)...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibitory activity against gelatinase-B(MMP-9).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM50335970(1-cyclohexyl-3-(1-picolinoylpiperidin-4-yl)urea | ...)
Affinity DataIC50:  6.40nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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