Affinity DataKi: 0.230nM ΔG°: -55.0kJ/molepH: 7.5 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
Affinity DataKi: 2.70nMAssay Description:Tested for inhibition of cysteine proteinase IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
Affinity DataKi: 4.70nMAssay Description:Tested for inhibition of cysteine proteinase IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
Affinity DataKi: 6nMAssay Description:Inhibition of recombinant human MMP2 expressed in human HeLa cellsMore data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:Tested for inhibition of cysteine proteinase IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
Affinity DataKi: 18nM ΔG°: -44.2kJ/molepH: 7.5 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
Affinity DataKi: 19nMAssay Description:Slow binding inhibition of human recombinant MMP9 catalytic domain using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 substrateMore data for this Ligand-Target Pair
Affinity DataKi: 27nMAssay Description:Tested for inhibition of cysteine proteinase IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
Affinity DataKi: 28nMAssay Description:Inhibition of recombinant human MMP2More data for this Ligand-Target Pair
Affinity DataKi: 37nMAssay Description:Slow binding inhibition of human recombinant MMP2 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 substrateMore data for this Ligand-Target Pair
Affinity DataKi: 53nMAssay Description:Slow binding inhibition of human recombinant MMP14 catalytic domain using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 substrateMore data for this Ligand-Target Pair
Affinity DataKi: 60nMAssay Description:Tested for inhibition of cysteine proteinase IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
Affinity DataKi: 85nMAssay Description:Slow binding inhibition of human recombinant MMP2 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 substrateMore data for this Ligand-Target Pair
Affinity DataKi: 90nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as KonMore data for this Ligand-Target Pair
Affinity DataKi: 100nMAssay Description:Tested for inhibition of cysteine proteinase IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
Affinity DataKi: 113nMAssay Description:Tested for inhibition of cysteine proteinase IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
Affinity DataKi: 119nMAssay Description:Slow binding inhibition of human recombinant MMP14 catalytic domain using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 substrateMore data for this Ligand-Target Pair
Affinity DataKi: 120nMAssay Description:Tested for inhibition of cysteine proteinase IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
Affinity DataKi: 120nMAssay Description:Slow binding inhibition of human recombinant MMP14 catalytic domain using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 substrateMore data for this Ligand-Target Pair
Affinity DataKi: 127nMAssay Description:Slow binding inhibition of human recombinant MMP2 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 substrateMore data for this Ligand-Target Pair
Affinity DataKi: 150nMAssay Description:Slow binding inhibition of human recombinant MMP9 catalytic domain using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 substrateMore data for this Ligand-Target Pair
Affinity DataKi: 160nMAssay Description:Inhibition of recombinant human MMP9 expressed in human HeLa cellsMore data for this Ligand-Target Pair
Affinity DataKi: 190nMAssay Description:Slow binding inhibition of human recombinant MMP9 catalytic domain using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 substrateMore data for this Ligand-Target Pair
Affinity DataKi: 320nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as KonMore data for this Ligand-Target Pair
Affinity DataKi: 400nMAssay Description:Inhibition of recombinant human MMP9More data for this Ligand-Target Pair
Affinity DataKi: 500nMAssay Description:Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneMore data for this Ligand-Target Pair
Affinity DataKi: 620nMAssay Description:Binding affinity of the compound was determined against ETA receptor in porcine aortic smooth muscle membraneMore data for this Ligand-Target Pair
Affinity DataKi: 1.20E+3nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as KonMore data for this Ligand-Target Pair
Affinity DataKi: 1.70E+3nMAssay Description:Binding affinity of the compound was determined against ETA receptor in porcine aortic smooth muscle membraneMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+3nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as KonMore data for this Ligand-Target Pair
Affinity DataKi: 2.10E+3nMAssay Description:Non-competitive inhibition of MMP8 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 2.10E+3nMAssay Description:Non-competitive inhibition of human recombinant MMP8 catalytic domain using Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrateMore data for this Ligand-Target Pair
Affinity DataKi: 2.60E+3nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as KonMore data for this Ligand-Target Pair
Affinity DataKi: 2.70E+3nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as KonMore data for this Ligand-Target Pair
Affinity DataKi: 3.50E+3nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytesMore data for this Ligand-Target Pair
Affinity DataKi: 3.80E+3nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as KonMore data for this Ligand-Target Pair
Affinity DataKi: 4.00E+3nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as KonMore data for this Ligand-Target Pair
Affinity DataKi: 4.40E+3nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytesMore data for this Ligand-Target Pair
Affinity DataKi: 4.90E+3nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as KonMore data for this Ligand-Target Pair
Affinity DataKi: 7.70E+3nMAssay Description:Non-competitive inhibition of human recombinant MMP8 catalytic domain using Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrateMore data for this Ligand-Target Pair
Affinity DataKi: 8.59E+3nMAssay Description:Non-competitive inhibition of human recombinant MMP8 catalytic domain using Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrateMore data for this Ligand-Target Pair
Affinity DataKi: 9.50E+3nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as KonMore data for this Ligand-Target Pair
Affinity DataKi: >1.80E+4nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as KonMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+4nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytesMore data for this Ligand-Target Pair
Affinity DataKi: >2.20E+4nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as KonMore data for this Ligand-Target Pair
Affinity DataKi: 2.30E+4nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytesMore data for this Ligand-Target Pair
Affinity DataKi: 2.40E+4nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytesMore data for this Ligand-Target Pair
Affinity DataKi: 2.70E+4nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytesMore data for this Ligand-Target Pair
Affinity DataKi: >2.80E+4nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as KonMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Amgen
Curated by ChEMBL
Amgen
Curated by ChEMBL
Affinity DataKi: >3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair