TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Johnson & Johnson Prd
Curated by ChEMBL
Johnson & Johnson Prd
Curated by ChEMBL
Affinity DataKi: 7.30nMAssay Description:Displacement of [125I]C5a from human C5a receptor in U937 cellsMore data for this Ligand-Target Pair
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Johnson & Johnson Prd
Curated by ChEMBL
Johnson & Johnson Prd
Curated by ChEMBL
Affinity DataKi: 8.90nMAssay Description:Displacement of [125I]C5a from human C5a receptor in U937 cellsMore data for this Ligand-Target Pair
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Johnson & Johnson Prd
Curated by ChEMBL
Johnson & Johnson Prd
Curated by ChEMBL
Affinity DataKi: 9.70nMAssay Description:Displacement of [125I]C5a from human C5a receptor in U937 cellsMore data for this Ligand-Target Pair
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Johnson & Johnson Prd
Curated by ChEMBL
Johnson & Johnson Prd
Curated by ChEMBL
Affinity DataKi: 35nMAssay Description:Displacement of [125I]C5a from human C5a receptor in U937 cellsMore data for this Ligand-Target Pair
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Johnson & Johnson Prd
Curated by ChEMBL
Johnson & Johnson Prd
Curated by ChEMBL
Affinity DataKi: 86nMAssay Description:Displacement of [125I]C5a from human C5a receptor in U937 cellsMore data for this Ligand-Target Pair
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Johnson & Johnson Prd
Curated by ChEMBL
Johnson & Johnson Prd
Curated by ChEMBL
Affinity DataKi: 180nMAssay Description:Displacement of [125I]C5a from human C5a receptor in U937 cellsMore data for this Ligand-Target Pair
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Johnson & Johnson Prd
Curated by ChEMBL
Johnson & Johnson Prd
Curated by ChEMBL
Affinity DataKi: 180nMAssay Description:Displacement of [125I]C5a from human C5a receptor in U937 cellsMore data for this Ligand-Target Pair
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Johnson & Johnson Prd
Curated by ChEMBL
Johnson & Johnson Prd
Curated by ChEMBL
Affinity DataKi: 370nMAssay Description:Displacement of [125I]C5a from human C5a receptor in U937 cellsMore data for this Ligand-Target Pair
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Johnson & Johnson Prd
Curated by ChEMBL
Johnson & Johnson Prd
Curated by ChEMBL
Affinity DataKi: 680nMAssay Description:Displacement of [125I]C5a from human C5a receptor in U937 cellsMore data for this Ligand-Target Pair
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Johnson & Johnson Prd
Curated by ChEMBL
Johnson & Johnson Prd
Curated by ChEMBL
Affinity DataKi: 1.20E+3nMAssay Description:Displacement of [125I]C5a from human C5a receptor in U937 cellsMore data for this Ligand-Target Pair
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Johnson & Johnson Prd
Curated by ChEMBL
Johnson & Johnson Prd
Curated by ChEMBL
Affinity DataKi: 3.70E+3nMAssay Description:Displacement of [125I]C5a from human C5a receptor in U937 cellsMore data for this Ligand-Target Pair
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Johnson & Johnson Prd
Curated by ChEMBL
Johnson & Johnson Prd
Curated by ChEMBL
Affinity DataKi: 8.30E+3nMAssay Description:Displacement of [125I]C5a from human C5a receptor in U937 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human recombinant JAK2More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human recombinant JAK2More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
Affinity DataIC50: 6.46nMpH: 7.4 T: 2°CAssay Description:DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 ...More data for this Ligand-Target Pair
Affinity DataIC50: 8.30nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
Affinity DataIC50: 8.91nMpH: 7.4 T: 2°CAssay Description:DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 ...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
Affinity DataIC50: 12nMpH: 7.4 T: 2°CAssay Description:DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 ...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMpH: 7.4 T: 2°CAssay Description:DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 ...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMpH: 7.4 T: 2°CAssay Description:DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 ...More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
Affinity DataIC50: 17nMpH: 7.4 T: 2°CAssay Description:DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 ...More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
Affinity DataIC50: 23nMpH: 7.4 T: 2°CAssay Description:DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 ...More data for this Ligand-Target Pair
Affinity DataIC50: 25nMpH: 7.4 T: 2°CAssay Description:DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 ...More data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibition of rat JAK1More data for this Ligand-Target Pair
Affinity DataIC50: 30nMpH: 7.4 T: 2°CAssay Description:DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 ...More data for this Ligand-Target Pair
Affinity DataIC50: 31nMpH: 7.4 T: 2°CAssay Description:DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 ...More data for this Ligand-Target Pair
Affinity DataIC50: 32nMpH: 7.4 T: 2°CAssay Description:DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 ...More data for this Ligand-Target Pair
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Johnson & Johnson Prd
Curated by ChEMBL
Johnson & Johnson Prd
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataIC50: 41nMpH: 7.4 T: 2°CAssay Description:DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 ...More data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
Affinity DataIC50: 47nMpH: 7.4 T: 2°CAssay Description:DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 ...More data for this Ligand-Target Pair
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Johnson & Johnson Prd
Curated by ChEMBL
Johnson & Johnson Prd
Curated by ChEMBL
Affinity DataIC50: 67nMAssay Description:Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataIC50: 67nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
Affinity DataIC50: 74nMAssay Description:Inhibition of JAK1 in human whole blood assessed as inhibition of IL-6-induced pSTAT1More data for this Ligand-Target Pair
Affinity DataIC50: 74nMpH: 7.4 T: 2°CAssay Description:DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 ...More data for this Ligand-Target Pair
Affinity DataIC50: 79nMpH: 7.4 T: 2°CAssay Description:DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 ...More data for this Ligand-Target Pair
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Johnson & Johnson Prd
Curated by ChEMBL
Johnson & Johnson Prd
Curated by ChEMBL
Affinity DataIC50: 82nMAssay Description:Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataIC50: 83nMpH: 7.4 T: 2°CAssay Description:DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 ...More data for this Ligand-Target Pair
Affinity DataIC50: 85nMpH: 7.4 T: 2°CAssay Description:DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 ...More data for this Ligand-Target Pair