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Found 59 with Last Name = 'yates' and Initial = 'p'
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM4685((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)
Affinity DataKi:  0.0000150nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM577((3S)-oxolan-3-yl N-[(2S,3R)-4-[(4-aminobenzene)(2-...)
Affinity DataKi:  0.0000570nMAssay Description:Inhibition of HIV1 protease by fluorescent peptide substrate based assayMore data for this Ligand-Target Pair
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)
Affinity DataKi:  0.00147nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50479982(Aptivus | CHEBI:63628 | Tipranavir | U-140690 | US...)
Affinity DataKi:  0.00800nMAssay Description:Inhibition of HIV1 protease by fluorescent peptide substrate based assayMore data for this Ligand-Target Pair
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM577((3S)-oxolan-3-yl N-[(2S,3R)-4-[(4-aminobenzene)(2-...)
Affinity DataKi:  0.0360nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
TargetLIM domain kinase 1(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299583((S)-N-(3-bromophenyl)-N'-cyano-2-methyl-4-(5-methy...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of LIMK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299619((S)-3-(N'-cyano-2-methyl-4-(5-methyl-7H-pyrrolo[2,...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299583((S)-N-(3-bromophenyl)-N'-cyano-2-methyl-4-(5-methy...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299616((S)-N-(3-tert-butylphenyl)-N'-cyano-2-methyl-4-(5-...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299586((S)-3-(2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299615((S)-N'-cyano-N-(3-cyanophenyl)-2-methyl-4-(5-methy...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299607((S)-N-(3-bromophenyl)-4-(5-chloro-7H-pyrrolo[2,3-d...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299584((S)-N-(3-bromo-4-fluorophenyl)-N'-cyano-2-methyl-4...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299611((S)-N-(3-chlorophenyl)-N'-cyano-2-methyl-4-(5-meth...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299623((S)-N'-cyano-N-(3-(N-isopropylsulfamoyl)phenyl)-2-...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299613((S)-N'-cyano-N-(3-fluorophenyl)-2-methyl-4-(5-meth...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299614((S)-N'-cyano-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299612((S)-N-(3-chlorophenyl)-2-methyl-4-(5-methyl-7H-pyr...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299624((S)-N'-cyano-N-(3-(N-(2-hydroxyethyl)sulfamoyl)phe...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299621((S)-N-(3-(1,3-dihydroxypropan-2-ylcarbamoyl)phenyl...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299620((S)-N-(3-(2-hydroxyethylcarbamoyl)phenyl)-2-methyl...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299585((S)-N-(3-bromo-4-fluorophenyl)-2-methyl-4-(5-methy...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299586((S)-3-(2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of LIMK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299622((S)-3-(N'-cyano-2-methyl-4-(5-methyl-7H-pyrrolo[2,...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299617((S)-3-(N'-cyano-2-methyl-4-(5-methyl-7H-pyrrolo[2,...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299584((S)-N-(3-bromo-4-fluorophenyl)-N'-cyano-2-methyl-4...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of LIMK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299599((S)-N-(3-bromophenyl)-2-methyl-4-(5-methyl-7H-pyrr...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299602(CHEMBL570586 | Trans-N-(3-bromophenyl)-N'-cyano-2,...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299608((S)-N-(3-bromophenyl)-N'-cyano-2-methyl-4-(6-methy...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299601((S)-N-(3-bromophenyl)-N'-cyano-2-isopropyl-4-(5-me...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299618((S)-N-(3-(isopropylcarbamoyl)phenyl)-2-methyl-4-(5...)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299585((S)-N-(3-bromo-4-fluorophenyl)-2-methyl-4-(5-methy...)
Affinity DataIC50:  6.60nMAssay Description:Inhibition of LIMK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299610((S)-N-(3-bromophenyl)-2-methyl-4-(5-methyl-7H-pyrr...)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299606((+/-)-N-(3-bromophenyl)-N'-cyano-2-methyl-4-(7H-py...)
Affinity DataIC50:  8.10nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299598(CHEMBL568484 | N-(3-bromophenyl)-N'-cyano-4-(5-met...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299604(CHEMBL584968 | N-(3-bromophenyl)-3-(5-methyl-7H-py...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299600((R)-N-(3-bromophenyl)-2-methyl-4-(5-methyl-7H-pyrr...)
Affinity DataIC50:  37nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299597(CHEMBL571280 | N-(3-bromophenyl)-4-(5-methyl-7H-py...)
Affinity DataIC50:  38nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299585((S)-N-(3-bromo-4-fluorophenyl)-2-methyl-4-(5-methy...)
Affinity DataIC50:  51nMAssay Description:Inhibition of human ROCK1 expressed in baculovirus systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299593(1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N-(3-...)
Affinity DataIC50:  64nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299605(CHEMBL571261 | N-(3-bromophenyl)-N'-cyano-5-(5-met...)
Affinity DataIC50:  76nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299595(4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N-m-t...)
Affinity DataIC50:  92nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299603(CHEMBL570819 | cis-N-(3-bromophenyl)-2,6-dimethyl-...)
Affinity DataIC50:  133nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299596(CHEMBL568706 | N-(3-methoxyphenyl)-4-(5-methyl-7H-...)
Affinity DataIC50:  140nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299583((S)-N-(3-bromophenyl)-N'-cyano-2-methyl-4-(5-methy...)
Affinity DataIC50:  260nMAssay Description:Inhibition of human ROCK1 expressed in baculovirus systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299585((S)-N-(3-bromo-4-fluorophenyl)-2-methyl-4-(5-methy...)
Affinity DataIC50:  280nMAssay Description:Inhibition of human ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299594(CHEMBL573004 | N-(3-bromophenyl)-1-(5-methyl-7H-py...)
Affinity DataIC50:  300nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299584((S)-N-(3-bromo-4-fluorophenyl)-N'-cyano-2-methyl-4...)
Affinity DataIC50:  310nMAssay Description:Inhibition of human ROCK1 expressed in baculovirus systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299586((S)-3-(2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50:  490nMAssay Description:Inhibition of human ROCK1 expressed in baculovirus systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299591(CHEMBL576712 | N-(3-methoxyphenyl)-1-(5-methyl-7H-...)
Affinity DataIC50:  520nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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