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Found 10 Enz. Inhib. hit(s) with Target = 'Bcl-2-like protein 1' and Ligand = 'BDBM50181876'
TargetBcl-2-like protein 1(Homo sapiens (Human))
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50181876(CHEMBL371861 | N-(4'-fluoro-biphenyl-4-carbonyl)-3...)
Affinity DataKi:  36nMAssay Description:Inhibition of GST-tagged Bcl-xL (unknown origin) measured after 1 hr incubation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50181876(CHEMBL371861 | N-(4'-fluoro-biphenyl-4-carbonyl)-3...)
Affinity DataKi:  36nMAssay Description:Binding affinity to Bcl-XL by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50181876(CHEMBL371861 | N-(4'-fluoro-biphenyl-4-carbonyl)-3...)
Affinity DataKi:  2.50E+3nMAssay Description:Binding affinity to Bcl-XL in 1% human serum by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50181876(CHEMBL371861 | N-(4'-fluoro-biphenyl-4-carbonyl)-3...)
Affinity DataIC50:  122nMAssay Description:Inhibitory activity against Bcl-XL in presence of alpha1 acid glycoprotein from 1% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50181876(CHEMBL371861 | N-(4'-fluoro-biphenyl-4-carbonyl)-3...)
Affinity DataIC50:  1.50E+3nMAssay Description:Displacement of biotinylated Bim-BH3 from GST-tagged Bcl-Xl by AlphaSCREEN competitive assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50181876(CHEMBL371861 | N-(4'-fluoro-biphenyl-4-carbonyl)-3...)
Affinity DataIC50:  2.20E+3nMAssay Description:Binding affinity to human GST-tagged Bcl-Xl by luminescence proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50181876(CHEMBL371861 | N-(4'-fluoro-biphenyl-4-carbonyl)-3...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against Bcl-XL in presence of 1% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50181876(CHEMBL371861 | N-(4'-fluoro-biphenyl-4-carbonyl)-3...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against Bcl-XL in presence of HSA from 1% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50181876(CHEMBL371861 | N-(4'-fluoro-biphenyl-4-carbonyl)-3...)
Affinity DataKd:  1.90E+3nMAssay Description:Binding affinity to human GST-tagged Bcl-Xl assessed as dissociation rate by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50181876(CHEMBL371861 | N-(4'-fluoro-biphenyl-4-carbonyl)-3...)
Affinity DataKd:  900nMAssay Description:Binding affinity to human GST-tagged Bcl-Xl assessed as direct binding constant at steady state by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed