BDBM50181876 CHEMBL371861::N-(4'-fluoro-biphenyl-4-carbonyl)-3-nitro-4-(2-phenylsulfanyl-ethylamino)-benzenesulfonamide::N-[(4'-FLUORO-1,1'-BIPHENYL-4-YL)CARBONYL]-3-NITRO-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE

SMILES [O-][N+](=O)c1cc(ccc1NCCSc1ccccc1)S(=O)(=O)NC(=O)c1ccc(cc1)-c1ccc(F)cc1

InChI Key InChIKey=SWGIDRBGIJDBQO-UHFFFAOYSA-N

Data  4 KI  8 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50181876   

TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181876(CHEMBL371861 | N-(4'-fluoro-biphenyl-4-carbonyl)-3...)
Affinity DataKi:  36nMAssay Description:Binding affinity to Bcl-XL by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181876(CHEMBL371861 | N-(4'-fluoro-biphenyl-4-carbonyl)-3...)
Affinity DataKi:  36nMAssay Description:Inhibition of GST-tagged Bcl-xL (unknown origin) measured after 1 hr incubation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181876(CHEMBL371861 | N-(4'-fluoro-biphenyl-4-carbonyl)-3...)
Affinity DataKi:  433nMAssay Description:Binding affinity to Bcl2 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181876(CHEMBL371861 | N-(4'-fluoro-biphenyl-4-carbonyl)-3...)
Affinity DataKi:  2.50E+3nMAssay Description:Binding affinity to Bcl-XL in 1% human serum by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181876(CHEMBL371861 | N-(4'-fluoro-biphenyl-4-carbonyl)-3...)
Affinity DataIC50:  1.50E+3nMAssay Description:Displacement of biotinylated Bim-BH3 from GST-tagged Bcl-Xl by AlphaSCREEN competitive assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Mus musculus)
The Walter And Eliza Hall Institute Of Medical Research

Curated by ChEMBL
LigandPNGBDBM50181876(CHEMBL371861 | N-(4'-fluoro-biphenyl-4-carbonyl)-3...)
Affinity DataIC50:  1.42E+4nMAssay Description:Inhibition of binding of wild type mBIMBH3 peptide to mouse adenosine A1 receptor by surface plasmon resonance competition experimentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181876(CHEMBL371861 | N-(4'-fluoro-biphenyl-4-carbonyl)-3...)
Affinity DataIC50:  2.20E+3nMAssay Description:Binding affinity to human GST-tagged Bcl-Xl by luminescence proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181876(CHEMBL371861 | N-(4'-fluoro-biphenyl-4-carbonyl)-3...)
Affinity DataKd:  1.90E+3nMAssay Description:Binding affinity to human GST-tagged Bcl-Xl assessed as dissociation rate by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181876(CHEMBL371861 | N-(4'-fluoro-biphenyl-4-carbonyl)-3...)
Affinity DataKd:  900nMAssay Description:Binding affinity to human GST-tagged Bcl-Xl assessed as direct binding constant at steady state by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181876(CHEMBL371861 | N-(4'-fluoro-biphenyl-4-carbonyl)-3...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against Bcl-XL in presence of 1% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181876(CHEMBL371861 | N-(4'-fluoro-biphenyl-4-carbonyl)-3...)
Affinity DataIC50:  93nMAssay Description:Binding affinity to Bcl2 by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181876(CHEMBL371861 | N-(4'-fluoro-biphenyl-4-carbonyl)-3...)
Affinity DataIC50:  122nMAssay Description:Inhibitory activity against Bcl-XL in presence of alpha1 acid glycoprotein from 1% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181876(CHEMBL371861 | N-(4'-fluoro-biphenyl-4-carbonyl)-3...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against Bcl-XL in presence of HSA from 1% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181876(CHEMBL371861 | N-(4'-fluoro-biphenyl-4-carbonyl)-3...)
Affinity DataIC50:  6.30E+3nMAssay Description:Inhibitory activity against Bcl-XL in presence of HSA3 from 1% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed