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Found 3 Enz. Inhib. hit(s) with Target = 'DNA topoisomerase 2-alpha' and Ligand = 'BDBM21690'
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Redx Anti-Infectives

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human topoisomerase 2 assessed as reduction in decatenationMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Redx Anti-Infectives

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  1.54E+5nMAssay Description:Inhibition of human topoisomerase-2alpha using catenated DNA as substrate after 30 mins by ethidium bromide-based gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Redx Anti-Infectives

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50: >2.56E+5nMAssay Description:Inhibition of human DNA topoisomerase 2-alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed