Found 21 Enz. Inhib. hit(s) with Target = 'Histone deacetylase 6' and Ligand = 'BDBM50398716' TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Affinity DataKi: 30nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human HDAC6 (1 to 1215 residues) expressed in Baculovirus infected insect cells using Boc-Lys(Ac)-AMC...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant human HDAC6 using Ac-GAK(Ac)-AMC as substrate preincubated for 10 mins followed by substrate addition and measured after 30...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human HDAC6 expressed in HEK293/T17 cells using pre-incubated for 10 mins before Ac-GAK(Ac)-AM substrate addition and measured after 30...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 3.80nMAssay Description:Inhibition of human N-terminal tagged human HDAC6 expressed in HEK293T/17 using Ac-Gly-Ala-[Ac-Lys]-AMC as substrate preincubated for 10 mins followe...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human HDAC6 expressed in HEK293T/17 cells using Ac-GAK(Ac)-AMC as substrate preincubated for 10 mins followed by substrate ...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human HDAC6 (1 to 1215 residues) expressed in baculovirus infected sf9 insect cells using p53 (379 to...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 5.02nMAssay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 5.02nMAssay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 5.02nMAssay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 5.02nMpH: 8.0Assay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 5.02nMAssay Description:Inhibition of human recombinant HDAC6 expressed in Sf9 cells incubated for 2 hrs using RHKK-Ac fluorogenic substrateMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 5.20nMAssay Description:Inhibition of HDAC6 (unknown origin) preincubated for 10 mins followed by Ac-Leu-GlyLys(Ac)-AMC substrate addition measured after 30 mins by fluoresc...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of full length human recombinant HDAC6 expressed in Sf9 baculovirus system using FAM-labeled acetylated peptide as substrate by measuring ...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of N-terminal GST-tagged full length human recombinant HDAC6 expressed in baculovirus infected Sf9 cells using ZMAL (Z-Lys(Ac)-AMC) fluoro...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant HDAC6 using ZMAL (Z-Lys(Ac)-AMC) fluorogenic substrate incubated for 90 mins by fluorescence based assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged HDAC6 expressed in baculovirus infected sf9 insect cells pretreated with compound f...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged HDAC6 expressed in baculovirus infected sf9 insect cells pretreated with compound f...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 2.19E+3nMAssay Description:Inhibition of full length recombinant human HDAC6 expressed in baculovirus infected Sf9 insect cells using RHKKAc fluorogenic peptide as substrate pr...More data for this Ligand-Target Pair
