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Found 18 Enz. Inhib. hit(s) with Target = 'Histone deacetylase 8' and Ligand = 'BDBM19130'
TargetHistone deacetylase 8(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataKi:  130nMAssay Description:Inhibition of recombinant HDAC8More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  1.38nMAssay Description:Inhibition of HDAC8 (unknown origin) after 17 hrsMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  25nMAssay Description:Inhibition of human recombinant HDAC8 after 30 mins by fluorimetric assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human histone deacetylase 8 prepared from 293T cellsMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Mus musculus)
Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against histone deacetylase 8 prepared from mouse melanoma B16/BL6 cellsMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  90nMAssay Description:Inhibition of human HDAC8More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  90nMAssay Description:Inhibition of human HDAC8 by fluorimetric assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  100nMAssay Description:Inhibition of HDAC8 by in vitro deacetylation assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  196nMAssay Description:Inhibition of human HDAC8 by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  300nMAssay Description:Inhibition of HDAC8More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  390nMAssay Description:Inhibition of human recombinant HDAC8 using fluor de Lys as substrate preincubated for 5 mins followed by substrate addition measured after 25 mins b...More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  770nMAssay Description:Inhibition of human recombinant histone deacetylase 8More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  960nMAssay Description:Inhibition of N terminal hexahistidine-tagged human HDAC8 expressed in Sf9 cells after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  1.38E+3nMAssay Description:The inhibitory effects of compounds on histone deacetylase (HDAC) activity were determined using a fluorescence-based assay with electrophoretic sepa...More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  1.38E+3nMAssay Description:Inhibition of HDAC8 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrsMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  7.31E+4nMAssay Description:Inhibition of HDAC8 by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataKd:  490nMAssay Description:To determine the dissociation rate of the inhibitor, 1 µM HDAC8 and 20 µM inhibitor (syringe I) were mixed with 100 µM c-SAHA (syringe...More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataKd:  390nMpH: 7.5Assay Description:A fixed concentration of 1.5 µM was titrated with an increasing concentration of the respective inhibitor in protein storage buffer containing 5...More data for this Ligand-Target Pair