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Found 3 Enz. Inhib. hit(s) with Target = 'Ileal sodium/bile acid cotransporter' and Ligand = 'BDBM50140283'
TargetIleal sodium/bile acid cotransporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50140283((4R,5R)-3,3-Dibutyl-7-dimethylamino-5-(4-methoxy-p...)
Affinity DataIC50:  6.80nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIleal sodium/bile acid cotransporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50140283((4R,5R)-3,3-Dibutyl-7-dimethylamino-5-(4-methoxy-p...)
Affinity DataIC50:  7nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in Baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIleal sodium/bile acid cotransporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50140283((4R,5R)-3,3-Dibutyl-7-dimethylamino-5-(4-methoxy-p...)
Affinity DataIC50: >6.30E+4nMAssay Description:In vitro Inhibition of apical sodium-dependent bile acid transporter by measuring the uptake of [3H]-taurocholate in hamster ileal ringMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed