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Found 7 Enz. Inhib. hit(s) with Target = 'Myeloperoxidase' and Ligand = 'BDBM357629'
TargetMyeloperoxidase(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM357629(7-benzyl-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine ...)
Affinity DataIC50:  25nMAssay Description:Inhibition of recombinant human MPO incubated for 10 mins in presence of 240 mM NaCl and 10 uM H2O2 by aminophenyl fluorescein based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM357629(7-benzyl-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine ...)
Affinity DataIC50:  43nMAssay Description:Inhibition of recombinant human MPO incubated for 10 mins by amplex red dye based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM357629(7-benzyl-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine ...)
Affinity DataIC50:  55nMAssay Description:MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen catalog # A12222) which...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM357629(7-benzyl-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine ...)
Affinity DataIC50:  55nMAssay Description:MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen catal...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM357629(7-benzyl-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine ...)
Affinity DataIC50:  80nMAssay Description:Inhibition of recombinant human MPO incubated for 10 mins in presence of 120 mM NaCl by aminophenyl fluorescein based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Mus musculus)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM357629(7-benzyl-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine ...)
Affinity DataIC50:  9.50E+3nMAssay Description:Inhibition of PMA-induced MPO in mouse Neutrophil incubated for 3 mins by luminometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM357629(7-benzyl-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine ...)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition of PMA-induced MPO in human Neutrophil incubated for 3 mins by luminometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed