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Found 3 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase MARK2' and Ligand = 'BDBM247039'
TargetSerine/threonine-protein kinase MARK2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM247039(2-((1R,3aR, 6S,7R,7aS)-7- ((E)-2-(5-(2- cyanopheny...)
Affinity DataIC50:  4.07nMAssay Description:This assay measures the potency of the inventive compounds as PAR-1 receptor antagonists.Frozen HEK 293 Cells were plated in 384-well PDL coated plat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase MARK2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM247039(2-((1R,3aR, 6S,7R,7aS)-7- ((E)-2-(5-(2- cyanopheny...)
Affinity DataIC50:  4.43nMAssay Description:This assay measures the potency of the inventive compounds as PAR-1 receptor antagonists.Frozen HEK 293 Cells were plated in 384-well PDL coated plat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase MARK2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM247039(2-((1R,3aR, 6S,7R,7aS)-7- ((E)-2-(5-(2- cyanopheny...)
Affinity DataIC50:  11.3nMAssay Description:This assay measures the potency of the inventive compounds as PAR-1 receptor antagonists.Frozen HEK 293 Cells were plated in 384-well PDL coated plat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent