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Found 4 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM412810'
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Loxo Oncology

US Patent
LigandPNGBDBM412810(N-[[4-[4-amino-1-[(1R*,3S*)-3-hydroxycyclopentyl]p...)
Affinity DataIC50:  2.20nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Loxo Oncology

US Patent
LigandPNGBDBM412810(N-[[4-[4-amino-1-[(1R*,3S*)-3-hydroxycyclopentyl]p...)
Affinity DataIC50:  2.20nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Loxo Oncology

US Patent
LigandPNGBDBM412810(N-[[4-[4-amino-1-[(1R*,3S*)-3-hydroxycyclopentyl]p...)
Affinity DataIC50: <10nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Loxo Oncology

US Patent
LigandPNGBDBM412810(N-[[4-[4-amino-1-[(1R*,3S*)-3-hydroxycyclopentyl]p...)
Affinity DataIC50: <10nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent