Compile Data Set for Download or QSAR
maximum 50k data
Found 183 Enz. Inhib. hit(s) with all data for entry = 50012093
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554085(CHEMBL4750723)
Affinity DataIC50:  14nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as effect on amyloid beta42 level by meso scale discove...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554103(CHEMBL4758131)
Affinity DataIC50:  19nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as effect on amyloid beta42 level by meso scale discove...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554106(CHEMBL4799797)
Affinity DataIC50:  21nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554112(CHEMBL4745955)
Affinity DataIC50:  32nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554098(CHEMBL4749020)
Affinity DataIC50:  32nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554103(CHEMBL4758131)
Affinity DataIC50:  33nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554108(CHEMBL4777391)
Affinity DataIC50:  36nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554090(CHEMBL4760389)
Affinity DataIC50:  38nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554095(CHEMBL4786740)
Affinity DataIC50:  40nMAssay Description:Inhibition of recombinant CYP3A4 (unknown origin) by fluorescence-based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554094(CHEMBL4794797)
Affinity DataIC50:  40nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554074(CHEMBL4765020)
Affinity DataIC50:  46nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554085(CHEMBL4750723)
Affinity DataIC50:  47nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554073(CHEMBL4744393)
Affinity DataIC50:  48nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554089(CHEMBL4777113)
Affinity DataIC50:  50nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554109(CHEMBL4761020)
Affinity DataIC50: <50nMAssay Description:Inhibition of recombinant CYP3A4 (unknown origin) by fluorescence-based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554086(CHEMBL4746048)
Affinity DataIC50:  57nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554099(CHEMBL4763513)
Affinity DataIC50:  58nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50534361(CHEMBL4445443)
Affinity DataIC50:  58nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as effect on amyloid beta42 level by meso scale discove...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50534361(CHEMBL4445443)
Affinity DataIC50:  60nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554105(CHEMBL4762589)
Affinity DataIC50:  62nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533496(CHEMBL4438330)
Affinity DataIC50:  63nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554078(CHEMBL4780956)
Affinity DataIC50:  63nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554076(CHEMBL4795963)
Affinity DataIC50:  64nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554107(CHEMBL4759910)
Affinity DataIC50:  64nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554093(CHEMBL4794750)
Affinity DataIC50:  64nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554075(CHEMBL4754724)
Affinity DataIC50:  71nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554111(CHEMBL4798079)
Affinity DataIC50:  72nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554095(CHEMBL4786740)
Affinity DataIC50:  73nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554096(CHEMBL4751736)
Affinity DataIC50:  73nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554109(CHEMBL4761020)
Affinity DataIC50:  75nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554102(CHEMBL4741605)
Affinity DataIC50:  80nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554077(CHEMBL4797165)
Affinity DataIC50:  83nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554059(CHEMBL4746523)
Affinity DataIC50:  89nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554104(CHEMBL4783910)
Affinity DataIC50:  90nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554071(CHEMBL4758548)
Affinity DataIC50:  96nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554085(CHEMBL4750723)
Affinity DataIC50:  100nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as effect on amyloid beta40 level by meso scale discove...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554092(CHEMBL4748419)
Affinity DataIC50:  100nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554080(CHEMBL4796849)
Affinity DataIC50:  102nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554079(CHEMBL4781159)
Affinity DataIC50:  102nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50534361(CHEMBL4445443)
Affinity DataIC50:  104nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as effect on amyloid beta40 level by meso scale discove...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554064(CHEMBL4745663)
Affinity DataIC50:  105nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554110(CHEMBL4747572)
Affinity DataIC50:  109nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554072(CHEMBL4752898)
Affinity DataIC50:  114nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554100(CHEMBL4741380)
Affinity DataIC50:  126nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554084(CHEMBL4783110)
Affinity DataIC50:  126nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554068(CHEMBL4747005)
Affinity DataIC50:  136nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554087(CHEMBL4744088)
Affinity DataIC50:  144nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554088(CHEMBL4741060)
Affinity DataIC50:  144nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50554063(CHEMBL4753524)
Affinity DataIC50:  148nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533497(CHEMBL4476368)
Affinity DataIC50:  163nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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