Reaction Details Report a problem with these data
Target
Transcription activator BRG1 [1448-1575]
Ligand
BDBM394485
Substrate
n/a
Meas. Tech.
BRG1 TR-FRET Binding Assay
IC50
11.0±n/a nM
Citation
 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Therapeutic compounds and uses thereof US Patent  US10308614 Publication Date 6/4/2019 
Target
Name:
Transcription activator BRG1 [1448-1575]
Synonyms:
ATP-dependent helicase SMARCA4 | BAF190A | BRG1 | His-BRG1 (A1448-S1575) | SMARCA4 | SMCA4_HUMAN | SNF2B | SNF2L4 | Transcription activator BRG1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14937.42
Organism:
Human
Description:
P51532(A1448-S1575)
Residue:
128
Sequence:
AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES
  
Inhibitor
Name:
BDBM394485
Synonyms:
Enantiomer 1 and Enantiomer 2 of (trans-4a,8a)-2-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)decahydroisoquinolin-4a-ol | US10308614, Example 85
Type:
Small organic molecule
Emp. Form.:
C19H24N4O2
Mol. Mass.:
340.4195
SMILES:
Nc1nnc(cc1N1CC[C@]2(O)CCCC[C@@H]2C1)-c1ccccc1O |r|
Structure:
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