Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Dihydrofolate reductase
Ligand
BDBM50534415
Substrate
n/a
Meas. Tech.
ChEMBL_1928819 (CHEMBL4431995)
IC50
50000±n/a nM
Citation
Borsari, C; Luciani, R; Pozzi, C; Poehner, I; Henrich, S; Trande, M; Cordeiro-da-Silva, A; Santarem, N; Baptista, C; Tait, A; Di Pisa, F; Dello Iacono, L; Landi, G; Gul, S; Wolf, M; Kuzikov, M; Ellinger, B; Reinshagen, J; Witt, G; Gribbon, P; Kohler, M; Keminer, O; Behrens, B; Costantino, L; Tejera Nevado, P; Bifeld, E; Eick, J; Clos, J; Torrado, J; Jiménez-Antón, MD; Corral, MJ; Alunda, JM; Pellati, F; Wade, RC; Ferrari, S; Mangani, S; Costi, MP Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs. J Med Chem 59:7598-616 (2016) [PubMed] Article More Info.:
Target
Name:
Dihydrofolate reductase
Synonyms:
DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21453.99
Organism:
Homo sapiens (Human)
Description:
Recombinant human DHFR.
Residue:
187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Inhibitor
Name:
BDBM50534415
Synonyms:
CHEMBL4464764
Type:
Small organic molecule
Emp. Form.:
C15H10O5
Mol. Mass.:
270.2369
SMILES:
Oc1cccc(c1)-c1oc2ccc(O)cc2c(=O)c1O
Structure:
