Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 3
Ligand
BDBM50387667
Substrate
n/a
Meas. Tech.
ChEMBL_830654 (CHEMBL2061589)
IC50
30±n/a nM
Citation
 Nitta, A; Iura, Y; Tomioka, H; Sato, I; Morihira, K; Kubota, H; Morokata, T; Takeuchi, M; Ohta, M; Tsukamoto, S; Imaoka, T; Takahashi, T Discovery and structure-activity relationships of urea derivatives as potent and novel CCR3 antagonists. Bioorg Med Chem Lett 22:4951-4 (2012) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 3
Synonyms:
C-C CKR-3 | C-C chemokine receptor type 3 (CCR3) | CC-CKR-3 | CCR-3 | CCR3 | CCR3_HUMAN | CD_antigen=CD193 | CKR3 | CMKBR3 | Eosinophil eotaxin receptor
Type:
Enzyme
Mol. Mass.:
41053.88
Organism:
Homo sapiens (Human)
Description:
P51677
Residue:
355
Sequence:
MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
  
Inhibitor
Name:
BDBM50387667
Synonyms:
CHEMBL2058073
Type:
Small organic molecule
Emp. Form.:
C33H39FN4O2
Mol. Mass.:
542.6868
SMILES:
CC(C)c1ccccc1NC(=O)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 |r,TLB:28:27:20.21.26:23.24,THB:19:20:27:23.24|
Structure:
Search PDB for entries with ligand similarity: