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Target
Pendrin
Ligand
BDBM50512537
Substrate
n/a
Meas. Tech.
ChEMBL_1849515 (CHEMBL4350056)
IC50
6600±n/a nM
Citation
 Zhu, JS; Lu, JY; Tan, JA; Rivera, AA; Phuan, PW; Shatskikh, ME; Son, JH; Haggie, PM; Verkman, AS; Kurth, MJ Synthesis and evaluation of tetrahydropyrazolopyridine inhibitors of anion exchange protein SLC26A4 (pendrin). Bioorg Med Chem Lett 29:2119-2123 (2019) [PubMed]  Article 
Target
Name:
Pendrin
Synonyms:
Pds | Pendrin | S26A4_MOUSE | Slc26a4 | Sodium-independent chloride/iodide transporter | Solute carrier family 26 member 4
Type:
PROTEIN
Mol. Mass.:
85690.94
Organism:
Mus musculus
Description:
ChEMBL_119233
Residue:
780
Sequence:
MAARGGRSEPPQLAEYSCSYTVSRPVYSELAFQQQRERRLPERRTLRDSLARSCSCSRKRAFGVVKTLLPILDWLPKYRVKEWLLSDIISGVSTGLVGTLQGMAYALLAAVPVQFGLYSAFFPILTYFVFGTSRHISVGPFPVVSLMVGSVVLSMAPDDHFLVPSGNGSALNSTTLDTGTRDAARVLLASTLTLLVGIIQLVFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGILSIIYTLIEIFQNIGDTNIADFIAGLLTIIVCMAVKELNDRFKHRIPVPIPIEVIVTIIATAISYGANLEKNYNAGIVKSIPSGFLPPVLPSVGLFSDMLAASFSIAVVAYAIAVSVGKVYATKHDYVIDGNQEFIAFGISNVFSGFFSCFVATTALSRTAVQESTGGKTQVAGLISAVIVMVAIVALGRLLEPLQKSVLAAVVIANLKGMFMQVCDVPRLWKQNKTDAVIWVFTCIMSIILGLDLGLLAGLLFALLTVVLRVQFPSWNGLGSVPSTDIYKSITHYKNLEEPEGVKILRFSSPIFYGNVDGFKKCINSTVGFDAIRVYNKRLKALRRIQKLIKKGQLRATKNGIISDIGSSNNAFEPDEDVEEPEELNIPTKEIEIQVDWNSELPVKVNVPKVPIHSLVLDCGAVSFLDVVGVRSLRMIVKEFQRIDVNVYFALLQDDVLEKMEQCGFFDDNIRKDRFFLTVHDAILHLQNQVKSREGQDSLLETVARIRDCKDPLDLMEAEMNAEELDVQDEAMRRLAS
  
Inhibitor
Name:
BDBM50512537
Synonyms:
CHEMBL4474736
Type:
Small organic molecule
Emp. Form.:
C21H20ClFN4O2
Mol. Mass.:
414.861
SMILES:
Cn1nc(COc2cccc(F)c2)c2CN(CCc12)C(=O)Nc1ccc(Cl)cc1
Structure:
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