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Target
Proteasome subunit beta type-10
Ligand
BDBM50517636
Substrate
n/a
Meas. Tech.
ChEMBL_1869378 (CHEMBL4370444)
IC50
325±n/a nM
Citation
 Xin, BT; Huber, EM; de Bruin, G; Heinemeyer, W; Maurits, E; Espinal, C; Du, Y; Janssens, M; Weyburne, ES; Kisselev, AF; Florea, BI; Driessen, C; van der Marel, GA; Groll, M; Overkleeft, HS Structure-Based Design of Inhibitors Selective for Human Proteasome ?2c or ?2i Subunits. J Med Chem 62:1626-1642 (2019) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-10
Synonyms:
LMP10 | Low molecular mass protein 10 | MECL1 | Macropain subunit MECl-1 | Multicatalytic endopeptidase complex subunit MECl-1 | PSB10_HUMAN | PSMB10 | Proteasome MECl-1 | Proteasome subunit beta-2i
Type:
PROTEIN
Mol. Mass.:
28940.51
Organism:
Homo sapiens (Human)
Description:
ChEMBL_106197
Residue:
273
Sequence:
MLKPALEPRGGFSFENCQRNASLERVLPGLKVPHARKTGTTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMVASKMELHALSTGREPRVATVTRILRQTLFRYQGHVGASLIVGGVDLTGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDRFQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVDACVITKTGAKLLRTLSSPTEPVKRSGRYHFVPGTTAVLTQTVKPLTLELVEETVQAMEVE
  
Inhibitor
Name:
BDBM50517636
Synonyms:
CHEMBL4541019
Type:
Small organic molecule
Emp. Form.:
C33H49N5O5S2
Mol. Mass.:
659.903
SMILES:
CC(C)C[C@H](NC(=O)[C@H](CC1CCC(C)CC1)NC(=O)c1cnc(C)s1)C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r,wU:4.3,wD:29.31,8.8,(44.64,-35.62,;44.64,-37.16,;45.97,-37.93,;43.3,-37.93,;43.3,-39.47,;41.97,-40.24,;40.64,-39.47,;40.64,-37.93,;39.3,-40.24,;39.3,-41.78,;40.63,-42.55,;40.63,-44.08,;41.96,-44.85,;43.29,-44.08,;44.62,-44.86,;43.29,-42.54,;41.96,-41.77,;37.97,-39.47,;36.63,-40.24,;36.63,-41.78,;35.31,-39.47,;33.9,-40.09,;32.88,-38.95,;33.65,-37.62,;33.03,-36.21,;35.15,-37.94,;44.64,-40.24,;44.64,-41.78,;45.97,-39.47,;47.3,-40.24,;47.3,-41.78,;48.64,-42.55,;48.63,-44.09,;49.96,-44.86,;51.3,-44.09,;52.63,-44.86,;53.96,-44.09,;51.29,-42.55,;49.96,-41.78,;48.64,-39.47,;49.97,-40.24,;51.3,-39.46,;52.64,-40.24,;50.52,-38.13,;52.07,-38.12,)|
Structure:
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