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Target
Tyrosine-protein kinase Lck
Ligand
BDBM109863
Substrate
n/a
Meas. Tech.
ChEMBL_1996112 (CHEMBL4630007)
IC50
1500±n/a nM
Citation
 Noji, S; Hara, Y; Miura, T; Yamanaka, H; Maeda, K; Hori, A; Yamamoto, H; Obika, S; Inoue, M; Hase, Y; Orita, T; Doi, S; Adachi, T; Tanimoto, A; Oki, C; Kimoto, Y; Ogawa, Y; Negoro, T; Hashimoto, H; Shiozaki, M Discovery of a Janus Kinase Inhibitor Bearing a Highly Three-Dimensional Spiro Scaffold: JTE-052 (Delgocitinib) as a New Dermatological Agent to Treat Inflammatory Skin Disorders. J Med Chem 63:7163-7185 (2020) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Lck
Synonyms:
2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase
Type:
n/a
Mol. Mass.:
57987.83
Organism:
Homo sapiens (Human)
Description:
P06239
Residue:
509
Sequence:
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
  
Inhibitor
Name:
BDBM109863
Synonyms:
US8609647, 1 | US8609647, 15 | US8609647, 2 | US8609647, 23
Type:
Small organic molecule
Emp. Form.:
C17H20N6O
Mol. Mass.:
324.3803
SMILES:
CC1CN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12
Structure:
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