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Target
Proteasome subunit beta type-2
Ligand
BDBM50307486
Substrate
n/a
Meas. Tech.
ChEMBL_611027 (CHEMBL1073016)
IC50
>10000±n/a nM
Citation
 Geurink, PP; Liu, N; Spaans, MP; Downey, SL; van den Nieuwendijk, AM; van der Marel, GA; Kisselev, AF; Florea, BI; Overkleeft, HS Incorporation of fluorinated phenylalanine generates highly specific inhibitor of proteasome's chymotrypsin-like sites. J Med Chem 53:2319-23 (2010) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-2
Synonyms:
20S proteasome | PSB2_HUMAN | PSMB2 | Proteasome Macropain subunit
Type:
PROTEIN
Mol. Mass.:
22837.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1294233
Residue:
201
Sequence:
MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSVRIIDKNGIHDLDNISFPKQGS
  
Inhibitor
Name:
BDBM50307486
Synonyms:
5,5-difluoro-1,3,7,9-tetramethyl-10-(4-(1-((S)-1-((S)-1-((S)-1-((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-ylamino)-1-oxo-3-(perfluorophenyl)propan-2-ylamino)-1-oxo-3-phenylpropan-2-ylamino)-1-oxo-3-phenylpropan-2-yl)-1H-1,2,3-triazol-4-yl)butyl)-5H-dipyrrolo[1,2-c:1',2'-f][1,3,2]diazaborinin-4-ium-5-uide | CHEMBL578518
Type:
Small organic molecule
Emp. Form.:
C55H60BF7N8O5
Mol. Mass.:
1056.915
SMILES:
CC(C)C[C@H](NC(=O)[C@H](Cc1c(F)c(F)c(F)c(F)c1F)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)n1cc(CCCCC2=C3C(C)=CC(C)=[N+]3[B-](F)(F)n3c(C)cc(C)c23)nn1)C(=O)[C@@]1(C)CO1 |r,c:53,56,59|
Structure:
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